Polyphenols Applications News - Polyphenols Applications World Congress

Best Scientific Contribution Award for Advancing Polyphenols in Oncotherapy at Polyphenols Applications 2024

2024-09-30T14:01:08+00:00

Prof. José M. Estrela from the University of Valencia has received the Best Scientific Contribution Award at Polyphenols Applications 2024 for his research on “Polyphenols in Oncotherapy: Moving Forward from the Bench to Clinical Applications.” His work addresses the challenge of polyphenols' poor bioavailability in vivo and their potential in cancer treatment.

While polyphenols demonstrate significant anti-cancer effects in preclinical studies—such as inducing cell cycle arrest and inhibiting angiogenesis—issues like limited absorption hinder their clinical application. Prof. Estrela highlights innovative delivery systems, including nanoparticles and liposomes, to enhance bioavailability and efficacy.

About Prof. Estrella

As a professor of physiology and director of the Cell Pathophysiology Unit at the University of Valencia, as well as research director at Scientia BioTech, Prof. Estrela is pioneering new anti-cancer strategies that integrate polyphenols for improved therapeutic outcomes. Congratulations to Prof. Estrela on this well-deserved recognition!

Molecular Mechanisms of Flavan-3-ol Degradation: Best Short Oral Presentation Award at Polyphenols Applications 2024

2024-09-30T13:50:45+00:00

Pascale Mosoni of INRAE has won the Best Short Oral Presentation Award at Polyphenols Applications 2024 for her research on “The Molecular Basis of the Degradation of Flavan-3-ols by the Human Gut Bacterium Eggerthella Lenta.”

Dr. Mosoni's presentation delved into how Eggerthella lenta metabolizes flavan-3-ols—polyphenols known for their cardiovascular benefits—into bioactive compounds in the gut. By identifying ten key genes responsible for this metabolic process through a transcriptomic approach, Dr. Mosoni's work has revealed that 27% of individuals lack the ability to convert these polyphenols, raising important questions about cardiovascular risk factors.

About Dr. Mosoni

Dr. Mosoni is a microbiologist in MEDIS (Microbiology, Digestive Environment & Health) laboratory at INRAE. Her research activities are currently focusing on the metabolism/degradation of dietary fibers and polyphenols by the human gut microbiota in order to better understand the effects of these plant dietary components on health through the action of the microbiota. The approaches used involve the isolation of anaerobic microorganisms contributing to these metabolic pathways and characterize their function (genes, enzymes, metabolites) and role in health. Her aim is to discover new generation pre- pro- syn-biotics, or effective bioactive molecules (postbiotics) to be used in preventive nutritional strategies.

Group Berkem Wins Second Best Poster Presentation Award at Polyphenols Applications 2024

2024-09-30T13:50:33+00:00

Congratulations to Jean-Paul Joseleau from Groupe Berkem for winning the Best Poster Presentation Award (2) at Polyphenols Applications 2024! His innovative research on “BERGENOL®, A Novel Vegetal Virucidal Agent for Hand Sanitizer Formulations” introduced a breakthrough in plant-based, alcohol-free sanitizers.

Derived from Vitis vinifera, Bergenol® demonstrated outstanding virucidal activity against a range of viruses, including those from the coronavirus and adenovirus families.

This recognition highlights the growing importance of natural, sustainable solutions in human hygiene, offering a safer alternative to chemical-based disinfectants. Well done to Dr. Joseleau for this achievement!

About Group Berkem

Groupe Berkem is a European Chemical manufacturer actively involved in the ecological transition. One of Groupe Berkem’s expertise is to use vegetal extracts in a wide range of sectors. It provides innovative and sustainable solutions to develop active ingredients for cosmetics and nutraceuticals, wood protection, disinfectants and human hygiene…

Nestlé Research Wins First Best Poster Presentation at Polyphenols Applications 2024

2024-09-30T13:50:29+00:00

Dr. Laure Poquet of Nestlé Research has been awarded the Best Poster Presentation (1) at Polyphenols Applications 2024 for her outstanding research on oleuropein metabolites.

Her poster, “Oleuropein Metabolites Are Biologically Active as Mitochondrial Calcium Activators at the Concentration Measured in Human Plasma,” highlighted the bioactivity of these metabolites derived from olive leaf extracts.

The study demonstrated that, at concentrations measurable in human plasma, these metabolites can activate mitochondrial calcium, leading to enhanced energy metabolism in muscle cells.

A new study was performed by Nestlé scientists to understand how the polyphenols from olive leaf extract can boost muscle energy. The main natural polyphenolic compound of this extract is oleuropein. Its metabolites circulating in plasma after intake were detected and quantified using a validated LC-MS/MS method. Their potential biological activities as mitochondrial activators were tested in vitro, at the circulating concentrations. The results showed that, although the level of oleuropein was low, its metabolites are biologically active in skeletal muscle cells and reach a total concentration in human blood sufficient to activate mitochondrial energy metabolism via mitochondrial Ca2+ activation.

This achievement marks a significant step in understanding the role of oleuropein in improving muscle function and supporting healthy aging. Congratulations to Dr. Poquet on this well-deserved recognition!

Videos On-Demand now Available

2024-09-13T11:10:43+00:00

All major and short oral presentations are now available on-demand. If you were not able to attend the live sessions, you can order and watch them later for 3 weeks. Order now.

Abstracts book of Polyphenols 2024 Congress

2024-09-12T13:09:43+00:00

The Polyphenols Applications 2024 Abstracts Book - containing all 123+ major, short talks and poster presentations - is now available.

The book is assigned with a DOI (Digital Object Identifier). This ensures a permanent and easily accessible online presence for the entire collection of work.

Polyphenols Applications 2024 Posters List

2024-09-11T11:59:14+00:00

More than 123 communications will be presented during Polyphenols Applications 2024, including more than 70 posters. Access full posters list.

Last updated on 12/09/2024

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Call for Papers: Special Issue on Polyphenols in Molecular Nutrition & Food Research Journal

2024-07-10T09:34:00+00:00

Molecular Nutrition & Food Research will be publishing a Special Issue following the 17th Polyphenols Applications 2024 World Congress, which took place in Milan, Sep 19th to 20th 2024.

Scientific sessions will focus on:

Polyphenols in Health and Disease;
Polyphenols, Microbiota and Metabolites;
Polyphenols and Food Research;
Clinical Applications and Future Directions.

The special issue will be gratefully guest-edited by Juan Carlos Espin (CEBAS-CSIC, Murcia, Spain) & Cristian Del Bo' (University of Milan, Italy), most well-known for their high standard research in the field.

Juan Carlos Espin
(CEBAS-CSIC, Murcia, Spain)

Cristian Del Bo'
(University of Milan, Italy)

The issue will publish high-quality peer-reviewed contributions, focussing on most recent findings of great novelty and interest. Please note: a contribution to the project is not dependent on an attendance to the conference.

Call for Papers Open:

You can start submitting your papers now, following the technical details below:

Contact email for authoring requests: [email protected]">[email protected].
Your request will be redirected to the guest editors who will decide on the selection of contributions.
Submission deadline: December 31st 2024
Article type: Research articles and Review articles will be accepted.
Authors guidelines: here.

More information about the issue here.

Polyphenols in Oncotherapy: Moving forward from the Bench to Clinical Applications

2024-04-03T22:00:00+00:00

It is a great pleasure to welcome Prof. José M. Estrela, University of Valencia, Spain, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Polyphenols in Oncotherapy: Moving forward from the Bench to Clinical Applications.

Prof. Estrela will discuss the latest clinical data in oncotherapy using a combination of modalities including hyperthermia, electromagnetic fields, chemotherapy, and natural polyphenols.

Presentation Key Points

Introduce the role of polyphenols, highlighting their potential as adjunctive therapies to enhance the efficacy of existing treatments.

Discuss the rationale behind combining hyperthermia, electromagnetic fields, chemotherapy, and polyphenols, emphasizing the potential synergistic effects and mechanisms of action.

Summarize preclinical evidence supporting the efficacy of the proposed combination therapy approach, including studies demonstrating tumor regression and enhanced cancer cell death.

Outline the steps needed to translate preclinical findings into clinical applications, including regulatory considerations, clinical trial design, and patient safety assessments.

Acknowledge potential challenges and limitations, such as variability in patient responses, treatment resistance, and the need for personalized treatment approaches.

Explore future directions for research and innovation in polyphenol-based oncotherapy, including the development of novel delivery methods, targeted therapies, and precision medicine approaches.

About José M. Estrela

José M. Estrela is an Associate professor in the Department of Physiology, University of Valencia, Spain. His study interests major on Physiology. In recent years, he has studied several on Cancer, Oncology, Polyphenols, Cancer Therapy, Tumors. He has published more than 103 articles in many journals.

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September 19-20, 2024 - Milan
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The Potential of Polyphenols in the Context of Senotherapy

2024-04-02T22:00:00+00:00

Dr. Alessandra Gambero, from Pontifical Catholic University of Campinas, Brazil, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

She will present her latest research on the Potential of Polyphenols in the Context of Senotherapy.

Learn more about her findings.

Presentation Summary

Cellular senescence is characterized by a stable cell proliferation arrest and the establishment of a secretory phenotype in normal cells in response to intrinsic and extrinsic stimuli.
Cellular senescence is associated with chronological aging and a response to environmental stressors.
Expanded knowledge about the role of senescence in the physiological context and disease processes and development of drugs that can counteract the harmful effects of cellular senescence as a therapeutic target.
Therefore, senotherapeutics can be classified as senolytics drugs that selectively eliminate senescent cells or senostatics (senomorphic) that inhibit, reverse, or prevent aspects associated with cellular senescence.
The most studied option combines dasatinib and quercetin, a natural polyphenol that targets BCL-2 and PI3K/AKT signaling pathways.
The various pharmacological mechanisms described for polyphenols suggest that others may have senotherapeutic effects, which has been the focus of our recent work.

About Alessandra Gambero

Graduated in Biological Sciences from Paulista State University Júlio de Mesquita Filho (1994), Master in Biological Sciences (Pharmacology) from Paulista State University Júlio de Mesquita Filho (1997), PhD in Pharmacology from University of São Paulo (2001), and Post-doctoral at Paul Sabatier University (Toulouse, France). Currently develops projects in the research area of Aging and cellular senescence, Foods with health claims, and Regenerative Medicine and Innovation in Health.

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September 19-20, 2024 - Milan
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Why Demonstrating the Health Benefits of Polyphenols isn't Easy: Considerations on Experimental Design to Enhance the Impact of Future Polyphenols Research

2024-04-02T10:00:00+00:00

It is a great pleasure to welcome Prof. Daniele Del Rio, University of Parma, Italy, as a keynote speaker at the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

Prof. Del Rio will open the conference with a speech entitled "Why Demonstrating the Health Benefits of Polyphenols isn't Easy: Considerations on Experimental Design to Enhance the Impact of Future Polyphenols Research".

About Daniele Del Rio

Prof. Daniele Del Rio is a Full Professor of Human Nutrition at the Department of Food and Drug and the Head of the School of Advanced Studies on Food and Nutrition at the University of Parma, in Italy. He is also the scientific director of the NNEdPro Global Center for Nutrition and Health and a Visiting Professor at the School of Biomedical Sciences, Ulster University, UK.

He serves as Editor in Chief of the International Journal of Food Sciences and Nutrition (Taylor & Francis). He is a proud Commendatore (Knight Commander) of the Order of Merit of the Italian Republic, and he is proudly growing a team of brilliant scientists.

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September 19-20, 2024 - Milan
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Coevolutionary Role of Host and Gut Microbiota in Polyphenol Health Effects: Metabotypes and Precision Health

2024-04-02T10:00:00+00:00

It is a great pleasure to welcome Prof. Juan Carlos Espín, Spanish National Research Council, Spain, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Coevolutionary Role of Host and Gut Microbiota in Polyphenol Health Effects: Metabotypes and Precision Health.

Presentation Summary

Individuals can be grouped into different metabotypes (metabolic types) based on their gut microbiota's ability to metabolize certain polyphenols, resulting in unique metabolites with varying molecular structures and biological activities. Thus, the effects of certain polyphenols will greatly depend on each individual's gut microbiota. By understanding the microbial ecologies responsible for these metabolic pathways, "precision-health" strategies could be developed to standardize the effects of polyphenols.

About Juan Carlos Espín

Juan Carlos Espín is is a full Research Professor at CEBAS-CSIC (Murcia, Spain). For the past 24 years, his main lines of research have focused on: i) the metabolism and biodistribution of polyphenols in humans, identifying the final responsible actors for biological effects; ii) the use of exosomes to deliver and enhance the biological activity of polyphenols and derived metabolites in systemic tissues; and iii) understanding why some polyphenols do not exert the same effect in all individuals. His research suggests that specific gut microbial ecologies play crucial roles in mediating the observed effects within the context of "precision health".

Juan Carlos has been a "highly-cited" researcher consecutively from 2018 to the present (only 0.1% of researchers worldwide are "highly-cited"). As of March 2024 (according to Scopus), he has an H-index of 85, with 230 JCR publications totaling approximately 23,000 citations, and has led the second highest-earning patent in the history of the CSIC.

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September 19-20, 2024 - Milan
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Interplay between Polyphenolic Compounds and Biological Rhythms

2024-04-02T09:00:00+00:00

Prof. Begoña Muguerza, from Universitat Rovira i Virgili, Spain, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

She will present her latest research on the Interplay between Polyphenolic Compounds and Biological Rhythms.

About Begoña Muguerza

She is a full Professor in the Biochemistry and Biotechnology Department, at the University Rovira I Virgili, Spain. Dr. Muguerza leads the Nutrigenomics Research Group, focusing its research on the study of the molecular mechanism by which food bioactive components, like (poly)phenols, exert health effects on metabolic pathologies. At present she is interested in the study of the interaction of the biological rhythms with the effectiveness of bioactive ingredients.

She has participated continuously in competitive projects, being PI of over 50. Dr. Muguerza is co-author of more than 150 articles in high-impact scientific journals and 15 patents. She has supervised 9 doctoral theses and currently she is mentoring 3 PhD students. In addition, she has also carried out management activities, being Head of the Biochemistry and Biotechnology Department and Coordinator of the Official Master Interuniversity Nutrition and Metabolism. Currently, she is the Coordinator of the Doctoral Programme in Nutrigenomics and Personalized Nutrition.

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September 19-20, 2024 - Milan
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Food-Derived Extracellular Vesicles as Nanocarriers of Bioactive Compounds: Therapeutic Potential

2024-04-02T08:00:00+00:00

Polyphenols Applications 2024 will welcome Dr. Alberto Davalos, University of Madrid, Spain, for its 17th World Congress this September in Milan.

Presentation Title: Food-Derived Extracellular Vesicles as Nanocarriers of Bioactive Compounds: Therapeutic Potential.

Presentation highlights

Extracellular vesicles from mammalian and plants as novel players in intercellular communication
Transport of natural bioactive molecules by dietary extracellular vesicles
Methods to isolate extracellular vesicles from foods
Delivery of bioactive compounds by extracellular vesicles
Extracellular vesicles as nanocarriers of dietary polyphenols
Therapeutic opportunities of dietary extracellular vesicles

About Alberto Davalos

Alberto Dávalos holds a degree in Pharmacy and Biochemistry by San Marcos University (Lima) and a PhD in Pharmacy by Universidad Complutense de Madrid (Madrid). He has conducted postdoctoral research at the Hospital Ramón y Cajal (Madrid), at Yale University School of Medicine, (New Haven), and at New York University School of Medicine (New York). Dr. Dávalos’s research program focuses in identifying and characterizing new noncoding RNAs (miRNAs, lncRNAs and other type of regulatory RNAs) that regulate lipid metabolism and the effects of minor dietary components (micronutrients) on their expression.

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September 19-20, 2024 - Milan
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Contribution of Polyphenols in the Modulation of Intestinal Permeability: Targeting Mechanisms and Clinical Trials

2024-04-02T00:00:00+00:00

Polyphenols Applications 2024 is honored to welcome Prof. Cristian Del Bo', active member of the scientific and local organizing committees, from Università degli Studi di Milano, Italy, as a speaker at its 17th World Congress this September in Milan.

Presentation Title: Contribution of Polyphenols in the Modulation of Intestinal Permeability: Targeting Mechanisms and Clinical Trials.

About Cristian Del Bo'

Cristian Del Bo’, PhD, is Associate Professor of Human Nutrition at the Department of Food, Environmental and Nutritional Sciences, at the University of Milan, Italy. His research focuses on the evaluation of the role of berries and berry-polyphenols in the modulation of markers related to cardiovascular risk. He performed both preclinical and clinical studies investigating the role blueberry bioactives in the modulation of vascular function, oxidative stress and inflammation. Prof Del Bo’ has published more than 100 articles in peer reviewed scientific journals. He is member of the Italian Society of Human Nutrition. He is on the Editorial Board of the International Journal of Food Sciences and Nutrition, and Nutrients.

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September 19-20, 2024 - Milan
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Resveratrol/Omega-3 Fatty Acids Association: Innovative Nutraceuticals to Counteract Ocular Diseases

2024-04-01T22:00:00+00:00

It is a great pleasure to welcome Prof. Dominique Delmas, University of Bourgogne, France, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Resveratrol/Omega-3 Fatty Acids Association: Innovative Nutraceuticals to Counteract Ocular Diseases.

Prof. Delmas will highlight the molecular mechanistic, preclinical and clinical studies of this new combination.

About Dominique Delmas

He is currently full professor in Biochemistry, Cellular and Molecular Biology at the University of Bourgogne (France). He exercises the function of Deputy Director of the Inserm Research Center Unit U1231 “Lipids, Nutrition, Cancers” in Dijon where he manages a research group entitled “Bioactive Molecules and Health” within the Inserm team “Cancer and Adaptive Immune Response”. He received his PhD on December 16th, 2002 concerning the potential antitumor effects of polyphenols, among them resveratrol.

The main research objectives of his group are to develop and to coordinate multidisciplinary and translational research from laboratory to clinical applications, including 1) the determination of early biomarkers in response to treatment; 2) the identification of new potential targets and the development of new therapeutic strategies by the use of molecules with low toxicity with a special attention on polyphenols. Due to the experience acquired in the field of natural substances and their implications in biology, he is an expert for many national and international organizations and member of the editorial board of several scientific journals (PLOS One, ACAMC, Nutrients, ROS journals). He has authored or coauthored over 97 original papers and comprehensive reviews on polyphenols health effects. He has also contributed to over 20 books chapters concerning the molecular mechanisms of polyphenols in tumoral cells and 118 international communications.

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September 19-20, 2024 - Milan
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Novel Development on the Potential Application of Pyranoanthocyanin as Colorants

2024-03-31T22:00:00+00:00

Prof. Monica Giusti, Ohio State University, USA, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

She will present the Novel Development on the Potential Application of Pyranoanthocyanin as Colorants.

Presentation Summary

Pyranoanthocyanins are derived from anthocyanins and are key contributors to the extra long stability of red wine color.
Yet, their limited stability limits their application in foods.
Different strategies were developed by Prof. Gusti and her team to produce a wide variety of pyranoanthocyanins from an array of different anthocyanin precursors, and in combination with different cofactors.
These pyranoanthocyanins show superior stability to factors such as pH, bleaching agents and heat.
They also present new challenges such as their decreased solubility in water and the low efficiency of production.
Different strategies to increase the yields of pyranoanthocyanin production from different sources will be discussed, as well as the role of their chemical structure on pyranoanthocyanin color, solubility, stability and potential for food applications.

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September 19-20, 2024 - Milan
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Angiogenesis as a Target of Dietary (Poly)phenols and Derived Metabolites

2024-03-31T22:00:00+00:00

It is a great pleasure to welcome Dr. Juan A. Giménez-Bastida, CEBAS-CSIC, Spain, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Angiogenesis as a Target of Dietary (Poly)phenols and Derived Metabolites.

Presentation Summary

Emphasis on the utilization of natural compounds, particularly (poly)phenols, as a promising avenue for regulating angiogenesis.
Objective: Provide comprehensive insights into the specific molecules capable of modulating angiogenic processes and elucidate the mechanisms through which these effects are realized.
Findings from preclinical investigations demonstrated the efficacy of tested (poly)phenols, whether identified in the bloodstream or systemic tissues, in modulating key in vitro angiogenesis processes.
Potential for transitioning from in vitro models to in vivo studies to further validate the efficacy and safety of (poly)phenols in regulating angiogenesis.

About Juan A. Giménez-Bastida

Juan A. Giménez-Bastida was awarded with a Juan de la Cierva Fellowship to work at CEBAS-CSIC. The results obtained described novel roles of urolithins as pro-senescence molecules against cancer cells and new anti-inflammatory effects (targeting 5-LOX pathway) in leukocytes. The excellent results at the completion of this fellowship are reflected by 7 publications in high-impact factor journals and the obtained funding within the European Marie Curie program.

Dr. Giménez-Bastida is now the project coordinator of the EU-funded PolyBiota project. This project investigates the role of the gut microbiota as a mediator of the beneficial effects associated with the consumption of ellagitannins and(or) isoflavones-rich diets. To accomplish the objectives, the PolyBiota project shows an innovative approach combininig cutting edge technologies, "big data" management as well as in vitro and in vivo models providing a holistic scene of the Diet-Gut microbiota-Host interaction.

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Antiviral Activity of Polyphenols: Latest Developments

2024-03-31T11:04:05+00:00

Prof. Sascha Venturelli, from the University of Hohenheim, Germany, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

He will present the latest developments in the antiviral activity of polyphenols.

Presentation Summary

The heterogenous class of polyphenols exhibit surprising and interesting antiviral effects.
The COVID-19 pandemic has also inspired research on polyphenols and their health promoting properties.
Current research including our own findings show that prenylated flavonoids (e.g. 6-prenylnaringenin) inhibit important viral enzymes of SARS-CoV-2.
Also other polyphenols (like quercetin and curcumin) exert antiviral effects on SARS-CoV-2.
Polyphenols seem to be promising natural drug candidates for other human viral diseases (e.g. hepatitis, influenca).

About Sascha Venturelli

Prof. Dr. Dr. Venturelli completed his biology studies at the Albert-Ludwigs-University of Freiburg and received his diploma with distinction in 2002. He successfully completed his medical studies with study visits at University College London Hospitals (Great Britain), Porter Memorial Hospital (USA) and University Hospital Zurich (Switzerland) at the Eberhard Karls University Tübingen in 2008. Both his scientific doctorate at the University of Hohenheim and his medical dissertation at the University Hospital of Tübingen were awarded "summa cum laude".

Initially, Prof. Dr. Dr. Venturelli worked as head of laboratory at the Department of Internal Medicine I at the University Hospital in Tübingen. During this time, he spent a research stay at the Peter MacCallum Cancer Centre in Melbourne (Australia) in the renowned research group of Prof. Ricky Johnstone from 2011 to 2012, funded by the DFG. Upon his return to the University Hospital in Tübingen, he established his own research group focusing on epigenetics and nutrition in the context of oncology as part of the Excellence Initiative of the Eberhard Karls University of Tübingen. In addition to his function as a study physician, during this time new active substances for cancer therapy were identified, characterised and successfully patented by the University Hospital of Tübingen. Prof. Dr. Dr. Venturelli was appointed deputy director of the Department of Vegetative and Clinical Physiology, Eberhard Karls University of Tübingen in 2016 and academic director in 2017.

In addition to various activities in the context of university self-administration such as study and examination commissioner, he was appointed to various national and international committees. In 2019 Prof. Dr. Dr. Venturelli accepted the call for the W3-Professorship at the University of Hohenheim and has since then been head of the Department of Biochemistry of Nutrition at the Institute of Nutritional Sciences.

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September 19-20, 2024 - Milan
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Effects of Polyphenols on Diabetes: A Mechanistic Insight

2024-03-29T23:00:00+00:00

It is a great pleasure to welcome Dr. Sonia Ramos Rivero, ICTAN-CSIC, Spain, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Effects of Polyphenols on Diabetes: A Mechanistic Insight.

Dr. Ramos will discuss the role of dietary polyphenols in diabetes type 2 highlighting their molecular mechanism of action, also in combination with anti-diabetic drugs.

About Sonia Ramos Rivero

Sonia Ramos is a Tenured Scientist at ICTAN-CSIC (Madrid, Spain), and she participates as a Researcher at the “Centro de Investigación Biomédicas en Red de Diabetes y Enfermedades Metabólicas Asociadas” (CIBERDEM). Her research activity in the field of nutritional biochemistry is focused on the study of the molecular mechanisms of action of bioactive food components, mainly phenolic compounds and their metabolites, and their potential effect on health and on the prevention of chronic diseases related to the oxidative stress, such as diabetes.

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September 19-20, 2024 - Milan
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Flavonoids & Critically ill Patients: From Experimental Study to Clinical Practice

2024-03-28T23:00:00+00:00

Prof. Wojciech Dabrowski, Medical University of Lublin, Poland, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

He will present his latest studies on Flavonoids & Critically ill Patients: From Experimental Study to Clinical Practice.

Presentation Highlights

Highlight Xanthohumol as a flavonoid with potential therapeutic benefits, with an emphasis on its promise as an adjunctive therapy to enhance the efficacy of existing treatments for septic shock and pulmonary fibrosis.
Present the rationale for using Xanthohumol in critically ill septic shock patients based on experimental studies.
Summarize biochemical findings showing reduced pro-inflammatory cytokines and oxidative stress markers.
Discuss clinical study results indicating improved outcomes for septic shock patients with Xanthohumol as adjunctive therapy.
Present data on enhanced lung function and quality of life in pulmonary fibrosis patients, including those with post-COVID complications.
Outline the necessary steps to translate experimental and preliminary clinical findings into routine clinical practice.
Emphasize the need for personalized treatment approaches to optimize outcomes.
Discuss future research opportunities, including novel delivery methods and targeted therapies.
Highlight the potential for precision medicine approaches in Xanthohumol-based treatments for septic shock and pulmonary fibrosis.

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September 19-20, 2024 - Milan
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Towards the Potency of Anthocyanin-Rich Extracts to Alleviate Side Effects of Chemotherapy

2024-03-28T12:15:00+00:00

It is a great pleasure to welcome Prof. Doris Marko, University of Vienna, Austria, to Polyphenols Applications 2024 this September in Milan.

Presentation Title: Towards the Potency of Anthocyanin-Rich Extracts to Alleviate Side Effects of Chemotherapy.

About Doris Marko

Doris Marko is a Professor of Food Chemistry and the Head of the Institute of Food Chemistry and Toxicology in the Faculty of Chemistry at the University of Vienna, Austria. She studied Food Chemistry at the University of Kaiserslautern, Germany. Starting in the field of preclinical drug development, she acquired profound expertise in the elucidation of molecular mechanisms of bioactive constituents arising from natural sources, focusing predominantly on their anticarcinogenic and chemopreventive effects.

Her research strategy aims at the substantiation of beneficial health effects ranging from basic molecular models to the development of respective in vivo biomarkers, including the assessment of potentially undesired application-limiting effects.

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September 19-20, 2024 - Milan
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Polyphenols & Fermented Food: The Optimization

2024-03-26T12:15:00+00:00

Dr. Pasquale Filannino, University of Bari, Italy, will be joining the 17th World Congress of Polyphenols Applications 2024 this September in Milan.

He will highlight the optimization of the benefits of polyphenols and fermented food for enhanced health.

About Pasquale Filannino

Pasquale Filannino is Associate Professor at the University of Bari "Aldo Moro" (Italy). He is also a member of the Steering Committee of the International Ph.D. School in "Food Engineering and Biotechnology" at the Free University of Bozen (Italy). His research focuses on microbial system biotechnology, fermented and functional foods, and microbial physiology.

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September 19-20, 2024 - Milan
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2-Ene Reductases of Lactobacilli, an Unexpected Diversity of Enzymes for Conversion of Phenolic Compounds

2024-03-25T12:15:00+00:00

Polyphenols Applications 2024 proudly announces that Prof. Michael Gänzle, active member of the scientific board, from University of Alberta, Canada, will be a featured speaker at its 17th World Congress this September in Milan.

Presentation Title: 2-Ene Reductases of Lactobacilli, an Unexpected Diversity of Enzymes for Conversion of Phenolic Compounds.

Presentation Summary

2-ene reductases are NADH-dependent enzymes that specifically reduce double bonds conjugated with an aromatic ring.
Plant-associated lactobacilli possess multiple homologues of HcrB, Par1, and other related enzymes from different bacteria.
These enzymes are involved in the conversion of various phenolic compounds, indicating a diverse enzymatic capability within lactobacilli.
The diversity of 2-ene reductases in lactobacilli suggests their role in metabolizing and modifying phenolic compounds.
This enzymatic diversity may have implications for the metabolism of dietary phenolics and potentially contribute to the functional properties of lactobacilli in various ecological niches.

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September 19-20, 2024 - Milan
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Polyphenols and Food Processing: The Critical Points

2024-03-25T12:15:00+00:00

Dr. Jianbo Xiao from Vigo University, Spain will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Polyphenols and Food Processing: The Critical Points.

About Jianbo Xiao

Dr. Jianbo Xiao is current a professor of Department of Food Science and Technology, University of Vigo (Spain) and an adjunct professor of Jinan University (China). He received PhD degree in nutrition from Okayama Prefectural University (Japan) in 2009. He worked as a Postdoc supported by AvH foundation at University of Würzbug, Germany (April 2013-May 2015). Dr. Xiao has been selected as Clarivate Analytics Highly Cited Researchers (2016, 2017, 2019, 2020, 2021, 2022).

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Tiffany Weir Earns Recognition at Polyphenols Applications 2023

2023-10-02T09:39:18+00:00

Dr. Tiffany Weir, a renowned professor from Colorado State University, USA, has been honored with the esteemed "Best Scientific Contribution" award at the Polyphenols Applications 2023 conference. This recognition comes on the back of her compelling presentation, "Polyphenol-Microbiome Interactions & Future of Nutrition".

With a position as a professor in Food Science and Human Nutrition at Colorado State University, Dr. Weir has made significant strides in the field. She spearheads a multifaceted translational research program, diligently uncovering the gut microbiota's role in bridging the connections between diet and host, aiming for enhanced cardiometabolic results.

As the coordinator of the Microbiome Network, she brings together a consortium of microbiome enthusiasts from various disciplines at Colorado State University. Dr. Weir's commitment to the field is further highlighted by her service as the Specialty Chief Editor for the Nutrition, Metabolism, and Microbiomes section of Frontiers in Microbiomes. Currently, she holds the esteemed position of Editor-in-Chief for npj Biofilms and Microbiomes.

A significant part of Dr. Weir's research is centered on deciphering the intricate relationship between our diets and the microbiome and its implications on human well-being. Recognizing that individual responses to dietary shifts can be highly varied, Dr. Weir and her team employ human-associated datasets and sophisticated bioinformatics tools. Their goal? To determine if variances in reactions to polyphenol interventions can be traced back to differences in gut microbial metabolism, which could, in turn, affect exposure to vital components.

The organizers and attendees of Polyphenols Applications 2023 extend their heartfelt congratulations to Dr. Weir, recognizing her commitment to and achievements in the realm of polyphenol research.

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
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Outstanding Contribution by Dr. Charareh Pourzand at Polyphenols Applications 2023

2023-10-02T09:23:22+00:00

The Polyphenols Applications 2023 committee acknowledges Dr. Charareh Pourzand from the University of Bath, UK, for her exemplary achievement in securing the Best Short Oral Presentation Award.

In her presentation titled "Hydroxycinnamic Acid Derivatives as Dual-Action Antioxidants and Iron Chelators for Shielding Skin Cells from UVA Photodamage", Dr. Pourzand provided a comprehensive overview of her research findings. Among the multiple hydroxycinnamic acid derivatives studied, trans-cinnamic acid (TCA) emerged as particularly potent in its photoprotective efficacy against UVA in skin cells. This was attributed to its pronounced capability to reduce both basal and UVA-induced increase in intracellular labile iron levels. Dr. Pourzand elaborated on the dual mechanistic role of hydroxycinnamic derivatives, with a notable emphasis on TCA, in counteracting UVA-induced damage in skin cells.

In general, Dr. Pourzand's Research on UVA photobiology specially in relation to skin photoaging has revealed that UVA component of sunlight has a dual damaging effect on skin cells. In one hand it generates harmful reactive oxygen species (ROS) and on the other hand it promotes the release of harmful free iron that acts as a catalyst to exacerbate the damaging effect of ROS, leading to irreversible skin photodamage in the form of wrinkling, sagging, etc .

Dr. Pourzand stated: "To counteract this dual effect of UVA, we are in process of identifying natural compounds based on polyphenols that can not only neutralise the UVA-induced ROS but also mop the free iron released by UVA. Since the properties and the concentration of such polyphenols can significantly change in different seasons or locations, our future research is concentrated on designing 'bio-inspired' molecules that are more stable than their natural counterparts but still maintain their dual functions. Such bifunctional compounds can then be added as photo-protectants into sunscreen formulations for a more robust protection against UVA photodamge exerted by sunlight".

Such advancements in the field of skin photoprotection are of immense importance, and the Polyphenols Applications 2023 team, along with the broader scientific community, recognizes and appreciates Dr. Pourzand's significant contribution.

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
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Best Poster Presentation Award of Polyphenols Applications 2023

2023-10-02T09:05:14+00:00

The Polyphenols Applications 2023 committee extends its sincere commendation to Samuele Venturi from Università degli Studi di Milano, Italy, for his distinguished achievement in receiving the Best Poster Presentation Award.

His research, titled "Effect of a Serving of Wild Blueberry (Vaccinium Angustifolium) Drink on Vascular Function Markers in Healthy Subjects: A Randomized, Placebo-controlled, Crossover Study", contributes to the understanding of dietary polyphenols and their potential cardiovascular benefits.

Furthermore, our gratitude extends to Dr. Cristian DelBo', a prominent speaker at Polyphenols Applications 2023. As the corresponding author, Dr. DelBo' played an instrumental role in guiding and supporting this award-winning research.

This study embodies the commitment to advancing scientific knowledge within the realm of polyphenol research. The committee and the broader scientific community recognize and value the significant contributions of both researchers.

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
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Polyphenols Applications 2023 Posters List

2023-07-31T11:59:14+00:00

More than 120 communicationswere presented during Polyphenols Applications 2023. Access full posters list.

Polyphenols Applications 2023 Congress
September 29-29, 2023 - Malta
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Natural polyphenol supplements reduce dietary iron absorption in adults with iron-loading diseases

2023-06-14T07:22:58+00:00

Prof. Michael Bruce Zimmermann, ETH Zurich, Switzerland, will join the Polyphenols Applications 2023 Congress and present his latest rearch about the "Natural polyphenol supplements reduce dietary iron absorption in adults with iron-loading diseases".

Dr. Zimmermann and his colleagues developed a new natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH). The polyphenol supplement reduced iron absorption by ~ 40% from meals and test drinks.

Their results indicate that when taken with meals, this natural polyphenol supplement can decrease dietary iron absorption, and might thereby reduce toxicity of body iron accumulation in patients with HH.

Join us in Polyphenols Applications 2023 to learn more about Prof. Zimmermann's talk.

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
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