Join the 17th World Congress on Polyphenols Applications 2024 on September 19-20, at Università degli Studi di Milano Statale, Milan, Italy.
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It is a great pleasure to welcome Prof. José M. Estrela, University of Valencia, Spain, to Polyphenols Applications 2024 this September in Milan.
Presentation Topic: Polyphenols in Oncotherapy: Moving forward from the Bench to Clinical Applications.
Prof. Estrela will discuss the latest clinical data in oncotherapy using a combination of modalities including hyperthermia, electromagnetic fields, chemotherapy, and natural polyphenols.
About José M. Estrela
José M. Estrela is an Associate professor in the Department of Physiology, University of Valencia, Spain. His study interests major on Physiology. In recent years, he has studied several on Cancer, Oncology, Polyphenols, Cancer Therapy, Tumors. He has published more than 103 articles in many journals.
Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Dr. Alessandra Gambero, from Pontifical Catholic University of Campinas, Brazil, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.
She will present her latest research on the Potential of Polyphenols in the Context of Senotherapy.
Learn more about her findings.
About Alessandra Gambero
Graduated in Biological Sciences from Paulista State University Júlio de Mesquita Filho (1994), Master in Biological Sciences (Pharmacology) from Paulista State University Júlio de Mesquita Filho (1997), PhD in Pharmacology from University of São Paulo (2001), and Post-doctoral at Paul Sabatier University (Toulouse, France). Currently develops projects in the research area of Aging and cellular senescence, Foods with health claims, and Regenerative Medicine and Innovation in Health.
Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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It is a great pleasure to welcome Prof. Daniele Del Rio, University of Parma, Italy, as a keynote speaker at the 17th World Congress on Polyphenols Applications 2024 this September in Milan.
Prof. Del Rio will open the conference with a speech entitled "Polyphenols Applications: Key Messages and Perspectives".
About Daniele Del Rio
Prof. Daniele Del Rio is a Full Professor of Human Nutrition at the Department of Food and Drug and the Head of the School of Advanced Studies on Food and Nutrition at the University of Parma, in Italy. He is also the scientific director of the NNEdPro Global Center for Nutrition and Health and a Visiting Professor at the School of Biomedical Sciences, Ulster University, UK.
He serves as Editor in Chief of the International Journal of Food Sciences and Nutrition (Taylor & Francis). He is a proud Commendatore (Knight Commander) of the Order of Merit of the Italian Republic, and he is proudly growing a team of brilliant scientists.
Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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It is a great pleasure to welcome Prof. Juan Carlos Espín, Spanish National Research Council, Spain, to Polyphenols Applications 2024 this September in Milan.
Presentation Topic: The Gut Microbiota as a Referee of Polyphenol Effects: Metabotypes and Precision Health.
About Juan Carlos Espín
Juan Carlos Espín is is a full Research Professor at CEBAS-CSIC (Murcia, Spain). For the past 24 years, his main lines of research have focused on: i) the metabolism and biodistribution of polyphenols in humans, identifying the final responsible actors for biological effects; ii) the use of exosomes to deliver and enhance the biological activity of polyphenols and derived metabolites in systemic tissues; and iii) understanding why some polyphenols do not exert the same effect in all individuals. His research suggests that specific gut microbial ecologies play crucial roles in mediating the observed effects within the context of "precision health".
Juan Carlos has been a "highly-cited" researcher consecutively from 2018 to the present (only 0.1% of researchers worldwide are "highly-cited"). As of March 2024 (according to Scopus), he has an H-index of 85, with 230 JCR publications totaling approximately 23,000 citations, and has led the second highest-earning patent in the history of the CSIC.
Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Polyphenols Applications 2024 will welcome Dr. Alberto Davalos, University of Madrid, Spain, for its 17th World Congress this September in Milan.
Dr. Davalos will discuss the promising role of plant-derived extracellular vesicles in revolutionizing therapeutic delivery systems, and highlight their potential applications and benefits in various medical contexts.
About Alberto Davalos
Alberto Dávalos holds a degree in Pharmacy and Biochemistry by San Marcos University (Lima) and a PhD in Pharmacy by Universidad Complutense de Madrid (Madrid). He has conducted postdoctoral research at the Hospital Ramón y Cajal (Madrid), at Yale University School of Medicine, (New Haven), and at New York University School of Medicine (New York). Dr. Dávalos’s research program focuses in identifying and characterizing new noncoding RNAs (miRNAs, lncRNAs and other type of regulatory RNAs) that regulate lipid metabolism and the effects of minor dietary components (micronutrients) on their expression.
Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Prof. Begoña Muguerza, from Universitat Rovira i Virgili, Spain, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.
She will present her latest research on the Interplay between Polyphenolic Compounds and Biological Rhythms.
About Begoña Muguerza
She is a full Professor in the Biochemistry and Biotechnology Department, at the University Rovira I Virgili, Spain. Dr. Muguerza leads the Nutrigenomics Research Group, focusing its research on the study of the molecular mechanism by which food bioactive components, like (poly)phenols, exert health effects on metabolic pathologies. At present she is interested in the study of the interaction of the biological rhythms with the effectiveness of bioactive ingredients.
She has participated continuously in competitive projects, being PI of over 50. Dr. Muguerza is co-author of more than 150 articles in high-impact scientific journals and 15 patents. She has supervised 9 doctoral theses and currently she is mentoring 3 PhD students. In addition, she has also carried out management activities, being Head of the Biochemistry and Biotechnology Department and Coordinator of the Official Master Interuniversity Nutrition and Metabolism. Currently, she is the Coordinator of the Doctoral Programme in Nutrigenomics and Personalized Nutrition.
Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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It is a great pleasure to welcome Prof. Dominique Delmas, University of Bourgogne, France, to Polyphenols Applications 2024 this September in Milan.
Presentation Topic: Resveratrol/Omega-3 Fatty Acids Association: Innovative Nutraceuticals to Counteract Ocular Diseases.
Prof. Delmas will highlight the molecular mechanistic, preclinical and clinical studies of this new combination.
About Dominique Delmas
He is currently full professor in Biochemistry, Cellular and Molecular Biology at the University of Bourgogne (France). He exercises the function of Deputy Director of the Inserm Research Center Unit U1231 “Lipids, Nutrition, Cancers” in Dijon where he manages a research group entitled “Bioactive Molecules and Health” within the Inserm team “Cancer and Adaptive Immune Response”. He received his PhD on December 16th, 2002 concerning the potential antitumor effects of polyphenols, among them resveratrol.
The main research objectives of his group are to develop and to coordinate multidisciplinary and translational research from laboratory to clinical applications, including 1) the determination of early biomarkers in response to treatment; 2) the identification of new potential targets and the development of new therapeutic strategies by the use of molecules with low toxicity with a special attention on polyphenols. Due to the experience acquired in the field of natural substances and their implications in biology, he is an expert for many national and international organizations and member of the editorial board of several scientific journals (PLOS One, ACAMC, Nutrients, ROS journals). He has authored or coauthored over 97 original papers and comprehensive reviews on polyphenols health effects. He has also contributed to over 20 books chapters concerning the molecular mechanisms of polyphenols in tumoral cells and 118 international communications.
Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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It is a great pleasure to welcome Dr. Juan A. Giménez-Bastida, CEBAS-CSIC, Spain, to Polyphenols Applications 2024 this September in Milan.
Presentation Topic: Angiogenesis as a Target of Dietary (Poly)phenols and Derived Metabolites
About Juan A. Giménez-Bastida
Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Please find here more information about the "Polyphenols Innovation Network" (PIN) & its projects.
Polyphenols Innovation Network
We are delighted to announce the launch of the Polyphenols Innovation Network (PIN), a pioneering initiative designed to accelerate progress in the field of polyphenols research by fostering a collaborative and innovative environment.
Aim of the Network
Under the banner of PIN, our mission is to assemble a diverse team of multidisciplinary experts, committed to advancing the frontiers of polyphenols research, applications, and innovation.
Projects of PIN
Three pioneering projects have been earmarked for initiation under the auspices of PIN:
Project 1: Artificial Intelligence and Polyphenols
This project will utilize AI's power to delve deeper into the understanding and utilization of polyphenols, aiming to develop predictive models for identifying novel therapeutic polyphenols and optimizing their formulations.
Project 2: Longevity & Polyphenols
Our focus here is on exploring the role of polyphenols in promoting longevity and preventing age-related diseases. We aim to uncover the molecular mechanisms through which polyphenols exert their beneficial effects on lifespan and healthspan.
Project 3: Space Food & Polyphenols
This project centers on creating polyphenol-enriched space food to boost astronauts' nutrition and well-being during space missions.
Funding of Projects
The Polyphenols Innovation Network is dedicated to securing necessary resources from public and private institutions to support these groundbreaking efforts.
How to participate?
To contribute to one of these 3 pioneering projects, Polyphenols Applications requests interested researchers and teams to submit a proposal detailing the following aspects:
We invite interested researchers and teams to join PIN by submitting their project proposals to polyphenols(at)polyphenols-site.com by April 10, 2024.
Submissions should include a project overview, its alignment with PIN's goals, anticipated challenges and proposed solutions, and a team profile. Proposals will be evaluated by our Selection Committee, and successful applicants will be invited to participate in the next phase of our initiative.
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Dr. Tiffany Weir, a renowned professor from Colorado State University, USA, has been honored with the esteemed "Best Scientific Contribution" award at the Polyphenols Applications 2023 conference. This recognition comes on the back of her compelling presentation, "Polyphenol-Microbiome Interactions & Future of Nutrition".
With a position as a professor in Food Science and Human Nutrition at Colorado State University, Dr. Weir has made significant strides in the field. She spearheads a multifaceted translational research program, diligently uncovering the gut microbiota's role in bridging the connections between diet and host, aiming for enhanced cardiometabolic results.
As the coordinator of the Microbiome Network, she brings together a consortium of microbiome enthusiasts from various disciplines at Colorado State University. Dr. Weir's commitment to the field is further highlighted by her service as the Specialty Chief Editor for the Nutrition, Metabolism, and Microbiomes section of Frontiers in Microbiomes. Currently, she holds the esteemed position of Editor-in-Chief for npj Biofilms and Microbiomes.
A significant part of Dr. Weir's research is centered on deciphering the intricate relationship between our diets and the microbiome and its implications on human well-being. Recognizing that individual responses to dietary shifts can be highly varied, Dr. Weir and her team employ human-associated datasets and sophisticated bioinformatics tools. Their goal? To determine if variances in reactions to polyphenol interventions can be traced back to differences in gut microbial metabolism, which could, in turn, affect exposure to vital components.
The organizers and attendees of Polyphenols Applications 2023 extend their heartfelt congratulations to Dr. Weir, recognizing her commitment to and achievements in the realm of polyphenol research.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
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The Polyphenols Applications 2023 committee acknowledges Dr. Charareh Pourzand from the University of Bath, UK, for her exemplary achievement in securing the Best Short Oral Presentation Award.
In her presentation titled "Hydroxycinnamic Acid Derivatives as Dual-Action Antioxidants and Iron Chelators for Shielding Skin Cells from UVA Photodamage", Dr. Pourzand provided a comprehensive overview of her research findings. Among the multiple hydroxycinnamic acid derivatives studied, trans-cinnamic acid (TCA) emerged as particularly potent in its photoprotective efficacy against UVA in skin cells. This was attributed to its pronounced capability to reduce both basal and UVA-induced increase in intracellular labile iron levels. Dr. Pourzand elaborated on the dual mechanistic role of hydroxycinnamic derivatives, with a notable emphasis on TCA, in counteracting UVA-induced damage in skin cells.
In general, Dr. Pourzand's Research on UVA photobiology specially in relation to skin photoaging has revealed that UVA component of sunlight has a dual damaging effect on skin cells. In one hand it generates harmful reactive oxygen species (ROS) and on the other hand it promotes the release of harmful free iron that acts as a catalyst to exacerbate the damaging effect of ROS, leading to irreversible skin photodamage in the form of wrinkling, sagging, etc .
Dr. Pourzand stated: "To counteract this dual effect of UVA, we are in process of identifying natural compounds based on polyphenols that can not only neutralise the UVA-induced ROS but also mop the free iron released by UVA. Since the properties and the concentration of such polyphenols can significantly change in different seasons or locations, our future research is concentrated on designing 'bio-inspired' molecules that are more stable than their natural counterparts but still maintain their dual functions. Such bifunctional compounds can then be added as photo-protectants into sunscreen formulations for a more robust protection against UVA photodamge exerted by sunlight".
Such advancements in the field of skin photoprotection are of immense importance, and the Polyphenols Applications 2023 team, along with the broader scientific community, recognizes and appreciates Dr. Pourzand's significant contribution.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
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The Polyphenols Applications 2023 committee extends its sincere commendation to Samuele Venturi from Università degli Studi di Milano, Italy, for his distinguished achievement in receiving the Best Poster Presentation Award.
His research, titled "Effect of a Serving of Wild Blueberry (Vaccinium Angustifolium) Drink on Vascular Function Markers in Healthy Subjects: A Randomized, Placebo-controlled, Crossover Study", contributes to the understanding of dietary polyphenols and their potential cardiovascular benefits.
Furthermore, our gratitude extends to Dr. Cristian DelBo', a prominent speaker at Polyphenols Applications 2023. As the corresponding author, Dr. DelBo' played an instrumental role in guiding and supporting this award-winning research.
This study embodies the commitment to advancing scientific knowledge within the realm of polyphenol research. The committee and the broader scientific community recognize and value the significant contributions of both researchers.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
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More than 120 communicationswere presented during Polyphenols Applications 2023. Access full posters list.
Polyphenols Applications 2023 Congress
September 29-29, 2023 - Malta
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Prof. Michael Bruce Zimmermann, ETH Zurich, Switzerland, will join the Polyphenols Applications 2023 Congress and present his latest rearch about the "Natural polyphenol supplements reduce dietary iron absorption in adults with iron-loading diseases".
Dr. Zimmermann and his colleagues developed a new natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH). The polyphenol supplement reduced iron absorption by ~ 40% from meals and test drinks.
Their results indicate that when taken with meals, this natural polyphenol supplement can decrease dietary iron absorption, and might thereby reduce toxicity of body iron accumulation in patients with HH.
Join us in Polyphenols Applications 2023 to learn more about Prof. Zimmermann's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Dr. Tiffany Weir, Colorado State University USA, will join the Polyphenols Applications 2023 Congress and present her latest rearch about the interactions between polyphenols and the microbiome.
Although consumption of dietary polyphenols is widely acknowledged as beneficial for human health, there is a high degree of variability in individual responses. Some of this variability may be due to differential processing of dietary polyphenols by the gut microbiome. Polyphenol metabolizing enzymes in the gut microbiota can influence the bioactivity and bioavailability of these compounds.
Dr. Weir and her colleagues are working to understand whether these polyphenol metabolizing enzymes are predictive of individual responses in vascular endothelial function to a dietary blueberry intervention in post-menopausal women. More broadly, understanding polyphenol metabolism in the gut will advance precision nutrition and potentially help identify complementary approaches to improve outcomes to nutrition interventions.
Dr. Weir will give a presentation titled: "Polyphenol-Microbiome Interactions & Future of Nutrition"
About Dr. Weir
Dr. Tiffany Weir is a professor of Food Science and Human Nutrition at Colorado State University. She leads an interdisciplinary translational research program focused on identifying the role of the gut microbiota in mediating diet-host interactions for improved cardiometabolic outcomes. Dr. Weir is the coordinator of the Microbiome Network, an interdisciplinary research and education consortium of microbiome scientists at Colorado State University. She also served as the Specialty Chief Editor for the Nutrition, Metabolism, and Microbiomes section of Frontiers in Microbiomes and is currently the Editor-in-Chief for npj Biofilms and Microbiomes.
Join us in Polyphenols Applications 2023 to learn more about Prof. Weir's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Prof. Hanne Frøkiær, University of Copenhagen, Denmark, will join the Polyphenols Applications 2023 Congress and present her latest rearch about the "Polyphenols & Immunomodulation: What do we know?".
Join us in Polyphenols Applications 2023 to learn more about Prof. Frøkiær's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Dr. Amala Soumyanath, Oregon Health & Science University, USA, will join the Polyphenols Applications 2023 Congress and present his latest rearch about the "Role of Polyphenolic Caffeoylquinic Acids in the Neurological Effects of Centella asiatica".
The traditional herbal remedy, Centella asiatica, shows remarkable effects related to cognitive function and mood in preclinical models. Its abundant triterpene constituents are usually reported as the active compounds.
However, studies conducted by Dr. Soumyanath and her colleagues, show that polyphenolic caffeoylquinic acid isomers also play an important role in this herb’s neurotropic effects in vitro and in vivo.
Join us in Polyphenols Applications 2023 to learn more about this topic.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Prof. Michael Gänzle, University of Alberta, Canada, will join the Polyphenols Applications 2023 Congress and present his latest rearch about the "Deglycosylation of secondary plant metabolites by lactobacilli".
Lactobacillaceae are among the major fermentation organisms in food fermentations but their metabolic pathways for conversion of (poly)-phenolic compounds have been elucidated only in the past two decades. The first step of conversion is the hydrolysis of esters or glycosides of phenolic compounds. This study aimed to evaluate the ability of Lactobacillus crispatus FUA3540, Companilactobacillus paralimentarius FUA3121, Lacticaseibacillus paracasei FUA3413, Lactiplantibacillus plantarum TMW1.460, Levilactobacillus hammesii LP38T, Furfurilactobacillus rossiae FUA3124, and Ff. milii FUA3430T and Fructilactobacillus sanfranciscensis DSM20451T to hydrolyse glycosides of secondary plant metabolites.
The genomes of these strains encoded for 5, 20, 8, 10, 2, 1, 2 and 0 β-glucosidases or phospho‑β‑glucosidases, respectively. L. crispatus, Cp. paralimentarius, Lc. paracasei and Lp. plantarum but not Lv. hammesii, Ff. rossiae or Ff. milii hydrolysed cellobiose. The hydrolysis of amygladin, esculin, and salicin matched the hydrolysis of cellobiose. With exception of Fl. sanfranciscensis, all strains hydrolysed spiraeoside and genistin. Lp. plantarum and Cp. paralimentarius additionally hydrolysed isoquercetin.
Prof. Gänzle's data support the previous observation that many of the glycosyl hydrolases in lactobacilli are specific for glycosylated secondary plant metabolites rather than di- and oligosaccharides. Increased knowledge on their substrate specificity will facilitate the selection of fermentation organisms to secondary plant metabolites with desirable or undesirable biological activities in food fermentations.
Join us in Polyphenols Applications 2023 to learn more about Prof. Gänzle's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Dr. Isabella D’Antuono from the Institute of Sciences of Food Production National Research Council (ISPA – CNR), Italy, will join the Polyphenols Applications 2023 Congress and present the talk entitled "Sustainable Sources for Polyphenols Recovery and their Application in Healthy Food".
Functional foods are an innovative response of food industries to consumer expectations. Their sector includes foods naturally rich in bioactive compounds or enriched in bio-ingredients stemming from unexploited sources, as a virtuous application of the circular economy concept.
Join us in Polyphenols Applications 2023 to learn more about Dr. D’Antuono's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Prof. Giulio Maria Pasinetti from 
Icahn School of Medicine at Mount Sinai, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Polyphenols in Depression & Neurodegenerative Diseases".
Join us in Polyphenols Applications 2023 to learn more about Dr. Pasinetti's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Corinthia Palace Malta will be the conference hotel of Polyphenols Applications 2023 on September 28-29.
Hotel Booking for Attendees: Special Rate
This year's attendees will be able to benefit from a discount on their booking at the conference hotel.
Available rooms include: Deluxe double, executive double, and executive suites for sole use.
The room rate includes full breakfast and VAT. Please note that the offer is valid until July 31, with a limited number of rooms.
Book you room with a preferential rate now.
If you need more than 2 rooms, please contact the hotel directly via email, mentioning that you will attend Polyphenols Applications 2023.
More about the hotel and activities in Malta.
Registration Details
Register early and book your spot to to learn about this year's new scientific outlook on Polyphenols Applications in lovely Malta.
Polyphenols Applications Congress
September 28-29, 2023 - Malta
Cellular senescence is a basic aging process that drives several age-related degenerative conditions. Compounds that selectively eliminate senescent cells, commonly called “senolytics”, have the potential to improve multiple degenerative conditions by targeting this key age-promoting process.
Several polyphenols have been shown to have senolytic activity, including the hops-derived chalconoid xanthohumol, presenting a new pathway by which these molecules might improve degenerative disease.
Dr. Christopher Wiley from Tufts University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Plant-Derived Polyphenols as Senolytic Agents".
About Dr. Wiley
Dr. Wiley is a Scientist II at the Jean Mayer USDA Human Nutrition Research Center on Aging and an Assistant Professor in the School of Medicine at Tufts University. His laboratory studies the interactions between metabolism and cell fate decisions such as cellular senescence and cell death, primarily in the context of aging and degenerative disease.
Join us in Polyphenols Applications 2023 to learn more about Dr. Wiley's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
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Dr. Laura Kresty from the University of Michigan, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Cranberry Polyphenols Inhibit Esophageal Cancer Through Reshapeing the Microbiome-Metabolome Axis".
Join us in Polyphenols Applications 2023 to learn more about Dr. Kresty's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Prof. Daniel Ruiz Molina from Universitat Autònoma de Barcelona, Spain, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Catechol-based Nanostructures in Medicine".
The experience and background of the team brings an important asset in the synthesis of “sticky” catechol based coatings and nanoparticles with bioadhesion properties in humid conditions. This involves: I) Synthesis of nanoparticles/nanocapsules intended for chemo-/phototherapy with encapsulated drugs and study of the controlled release, II) novel coating for biofunctionalization, colloidal stabilization in physiological media experimental conditions and III) a patch to damaged tissue that allow for the growth of healthy cells in a very effective way that will naturally induce a faster regeneration of the tissue.
Join us in Polyphenols Applications 2023 to learn more about Prof. Ruiz's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Dr. Diana Roopchand from Rutgers University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Multi-omics Approach Reveal Biomarkers of Metabolic Resilience in Healthy Participants Supplemented With Grape Polyphenols".
Grape polyphenols (GPs) extracted from grape pomace are rich in proanthocyanidins (PACs) compounds which are not bioavailable; however, evidence suggests their health benefits are likely mediated via the gut microbiota and/or bacterial metabolites.
Serum, fecal, and/or urine samples were collected before and after 2, 4, and 10 days of GP supplementation followed by shotgun metagenomic sequencing, mass spectrometry-based metaproteomics, and/or targeted metabolomics. Notable GP-induced bile acid changes appeared to be gender-specific and correlational analyses uncovered novel associations between gut microbes and metabolites associated with metabolic resilience.
Join us in Polyphenols Applications 2023 to learn more about Prof. Roopchand's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
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Prof. Trust Beta from the University of Manitoba, Canada, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Phenolic Compounds: Their Characterization and Bioaccessibility in Cereal Foods".
Globally, cereal grains serve as a source of affordable, staple foods. They comprise minor phytochemicals which may function to reduce oxidative stress. Grain phenolics are among compounds of interest as they have been shown to exhibit antioxidant and anti-inflammatory functions. Their characterization and bioaccessibility in cereal grains will be discussed during this presentation.
Join us in Polyphenols Applications 2023 to learn more about Prof. Beta's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
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Dr. Marianne Nissen Lund from the University of Copenhagen, Denmark will join the Polyphenols Applications 2023 congress and give a major presentation entitled "Biological Activities of Phenol-Amino Acid Adducts: Towards Enhancing Food Quality".
When polyphenols are oxidized to quinones they react with proteins in foods, with cysteine residues on proteins being kinetically preferred targets. Caffeic acid-cysteine and chlorogenic acid-cysteine adducts have been detected in commercial coffee-milk drinks. Thus, these adducts were synthesized and their anti-inflammatory activity was tested in lipopolysaccharide-treated RAW 264.7 cells in comparison to their parent phenolic acids.
Dr. Lund's results demonstrate that the addition of a cysteine moiety to phenolic acids enhances their anti-inflammatory responses in macrophages.
Join us in Polyphenols Applications 2023 to learn more about Dr. Lund's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Dr. Matheos Koffas from the Rensselaer Polytechnic Institute, School of Engineering, USA will join the Polyphenols Applications 2023 congress and will give a major presentation entitled "The Latest Advances in the Biotechnological Production of Phenolic Compounds".
Join us in Polyphenols Applications 2023 to learn more about Dr. Koffas's talk during the session "Polyphenols & Food Research: The Most Recent Developments".
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Prof. Andrew P. Neilson, North Carolina State University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Dietary Polyphenols Inhibit Production of Trimethylamine, a Gut Microbial Metabolite Associated With Aging and Atherosclerosis".
Cardiovascular disease causes ~32% of deaths worldwide. Elevated blood trimethylamine N-oxide (TMAO) levels were identified in 2011 as a risk factor for atherosclerosis development. TMAO is formed through a microbial-host axis involving oxidation of dietary choline to trimethylamine (TMA) by gut bacteria containing the cutC/D gene cluster. TMA is absorbed into circulation and oxidized to TMAO by hepatic flavin-containing monooxygenase 3. TMAO promotes cardiovascular disease through multiple mechanisms.
There is no FDA-approved drug to control TMAO levels, underscoring the need for complementary strategies to manage TMAO production. Dietary phytochemicals such as phenolics represent one potential solution. Phenolics have shown promise for altering the structure and function of the gut microbiome and providing cardioprotective benefits. Interest is emerging in TMAO-lowering activities of phenolics. There is a need to rapidly screen large numbers of phenolics and other dietary bioactives (compounds foods, extracts, etc.) to identify potential lead compounds for subsequent preclinical animal studies.
Prof. Neilson and his team developed and validated a high-throughput, low-volume 96-well ex vivo-in vitro anaerobic fecal fermentation method using human fecal samples and choline-d9 substrate and measuring the resultant TMA-d9. They paired this with a rapid, high-throughput analytical platform by employing an automated liquid handling robot for sample prep and a fast, sensitive 96-well LC-MS/MS method. Model validation experiments confirmed that choline-d9 utilization and TMA-d9 production occur with ~1:1 stoichiometry, with no background interference, and are dependent upon the presence of gut bacteria. Using this model, they identified chlorogenic acid, epicatechin and foods rich in these phenolics (coffee, cocoa and artichoke) as potent TMA production inhibitors.
In vitro and animal studies will elucidate the mechanisms of inhibition and demonstrate efficacy in vivo. TMA/TMAO-lowering activities may be a previously unknown mechanism by which dietary phenolics exert their cardioprotective effects.
Join us in Polyphenols Applications 2023 to learn more about Prof. Neilson's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
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