Polyphenols and Taste: Activation of Distinct Human Bitter Taste Receptors

The results obtained show that different polyphenols activate different combinations of the ~25 TAS2Rs. Notably, tannins are the first natural agonists found for TAS2R5 displaying high potency only toward this receptor. PGG and malvidin-3-glucoside showed the lowest EC₅₀ values, suggesting they could be responsible for the bitterness of fruits, vegetables and derived products even if they are present in very low concentrations.

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