Chemical Metabolomics – Unique Chemical Biology Tools to Explore Gut Microbiome and Dietary Metabolism
Prof. Daniel Globisch from Uppsala University, Sweden will talk about "Chemical Metabolomics – Unique Chemical Biology Tools to Explore Gut Microbiome and Dietary Metabolism" at our 18th World Congress on Polyphenols Applications 2025 wich will be held in Malta on 2-3 October.
The human body processes xenobiotics through phase I and phase II biotransformations that include phase II modifications like sulfation and glucuronidation linked to microbiota-host co-metabolism and dietary compound conversion. Our new chemical biology tools were developed to analyze these modifications and their unconjugated aglycons in human urine samples from a dietary polyphenol intervention, revealing significant changes in 91 sulfated and 94 glucuronidated metabolites across over 200 samples. This approach identified six key metabolites with high predictive accuracy for dietary intake, highlighting individual variability in dietary response and providing insights into gut microbiota-host interactions.
