Flavonoids: Promising Potential in Skin Wound Healing

Researchers from the Federal University of Sergipe, Brazil, conducted a review focusing on the healing potential of flavonoids in treating skin wounds. Flavonoids, a diverse class of compounds found abundantly in various plants, have long been recognized for their multifaceted biological functions. This systematic review, adhering to the rigorous guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, studied the extensive body of literature to assess the efficacy of flavonoids in promoting skin wound recovery in animal models.

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Graphical Abstract. Credits: Mikaella T.B.Carvalho et al., 2021Carvalho et al., 2021.

The review meticulously analyzed fifty-five articles, carefully selected based on stringent inclusion and exclusion criteria. The findings revealed an abundance of mechanisms through which flavonoids exert their therapeutic effects on skin wounds. From modulating the inflammatory cascade to facilitating angiogenesis and re-epithelialization, flavonoids showcased their remarkable ability to orchestrate various aspects of the wound healing process.

One of the pivotal revelations of the study was the intricate molecular interactions orchestrated by flavonoids within the wound microenvironment. These compounds were found to exert their influence on crucial cellular players such as macrophages, fibroblasts, and endothelial cells. Through mediating the expression of key signaling molecules including TGF-β1, VEGF, and IL-10, flavonoids demonstrated their proficiency in regulating essential pathways involved in wound repair.

Moreover, flavonoids exhibited a remarkable capacity to mitigate oxidative stress, dampen inflammatory cytokine release, and promote a favorable wound healing milieu by modulating various molecular pathways including MMPs and the Ras/Raf/MEK/ERK signaling cascade.

In conclusion, this comprehensive review highlights the promising therapeutic potential of flavonoids in advancing the field of wound healing. By clarifying the complex mechanisms underlying their efficacy, this study paves the way for future endeavors in both basic and translational research aimed at utilizing the therapeutic benefits of flavonoids for treating skin lesions.

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