Polyphenol-Powered Longevity: Salvia Extract Haenkenium Boosts Lifespan and Fights Aging
Recent research from the University of Padova has published findings that may transform our approach to aging and age-related conditions. The study reveals the significant potential of a botanical extract derived from Salvia haenkei, called Haenkenium (HK), in enhancing both lifespan and overall healthspan.
In a series of experiments on naturally aged mice, daily oral administration of HK was shown to significantly extend their lifespan. Not only did the treatment reduce key markers of age-induced inflammation, fibrosis, and senescence, but it also led to visible improvements in muscle strength and fur thickness compared to age-matched controls. These findings suggest that HK could be an effective therapeutic agent for addressing the accumulation of senescent cells, one of the key contributors to aging and degenerative diseases.
In addition to its effects on naturally aged mice, the study demonstrated that HK mitigated the senescence induced by the chemotherapy drug doxorubicin. By using p16LUC reporter mice, researchers observed a notable reduction in acute senescence levels with HK treatment.
A deeper investigation into the active compounds within HK revealed luteolin, a flavonoid, as the primary senomorphic component. Mechanistic analysis showed that luteolin disrupted the interaction between p16 and CDK6, a key molecular pathway involved in cellular aging.
Join us this September in Milan to learn more about the potential of phenolic compounds in the context of senolytics - and how they can combat age-related conditions.
What is luteolin?
Luteolin is a naturally occurring flavonoid, a type of polyphenol, found in many plants, including fruits, vegetables, and medicinal herbs. It is known for its antioxidant, anti-inflammatory, and anti-cancer properties. Luteolin has been the subject of various studies due to its potential health benefits, particularly in protecting cells from oxidative stress and inflammation, which are key factors in aging and the development of chronic diseases. Additionally, luteolin has been shown to modulate several biological pathways, including those involved in cellular aging, making it an area of interest in research on longevity and age-related diseases.
