Therapeutic Potential of Plant-Derived Extracellular Vesicles as Nanocarriers for Exogenous miRNAs
Recent research has showed the promising therapeutic potential of plant-derived extracellular vesicles (PDEVs) as nanocarriers for exogenous miRNAs.
Alberto Dávalos, Instituto Madrileño de Estudios Avanzados (IMDEA)-Alimentación, and his team, showed that broccoli, pomegranate, apple, and orange are excellent sources of extracellular vesicles.
sRNA sequencing identified miR159, miR162, miR166, and miR396 as the most abundant common miRNA families in these plants. miRNA-loaded EVs impact cell viability and apoptosis, modulating genes and suggesting their role in the bioactivity of plant EVs.
Certain polyphenols and phytochemicals are transported in plant EVs, contributing to their biological effects.
Overall, PDEVs have potential as versatile nanoplatforms for miRNA delivery, suitable for future RNA-based therapies.
For more details, refer to the full research article here.
Alberto Dávalos, will present these findings at the Polyphenols Application 2024 Conference. Join us and learn about the therapeutic potentials of PDEVs in enhancing human health through innovative nanocarrier applications.
Photo credit: María-Carmen López de las Hazas, Joao Tomé-Carneiro, Lorena del Pozo-Acebo, Andrea del Saz-Lara, Luis A. Chapado, Livia Balaguer, Enrique Rojo, Juan Carlos Espín, Carmen Crespo, Diego A. Moreno, Cristina García-Viguera, José M. Ordovás, Francesco Visioli, Alberto Dávalos, Pharmacological Research, (2023)
