Secoiridoids from Gentiana Lutea: Interaction with Bitter Receptors in the Gastrointestinal Tract and Enteroendocrine Pharmacological Application

Prof. Luigi Milella, from Università della Basilicata, Italy, will join Polyphenols Applications 2021. Prof. Milella will give a talk about "Secoiridoids from Gentiana Lutea: Interaction with Bitter Receptors in the Gastrointestinal Tract and Enteroendocrine Pharmacological Application".

According to his research, gentian root is known since centuries as an herbal bitter root and it has been traditionally used for several pharmacological applications. Moreover, the bitter principles of gentian root are secoiridoid glycosides like amarogentin and gentiopicrin. Recent evidences showed that bitter-tasting compounds modulate bitter taste receptors not only on the tongue but also in different parts of the gastrointestinal tract. In fact, it has been recently demonstrated as enteroendocrine in gut villi have functional bitter taste receptors and once activated they lead to release of enteroendocrine cell hormones. This latter can influence the dietary intake and there might be possibilities for studying their pharmacological application for regulating hunger and satiety.

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Digital Congress
www.polyphenols-site.com