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Polyphenols Applications 2022 World Congress Highlights

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The 15th World Congress on Polyphenols Applications will take place from the 28th to the 30th of September at ADEIT 'Fundación Universitat', Valencia, Spain, & Online after 2 years.

A workshop during Polyphenols Applications 2022 will be dedicated to Cannabis & Cannabinoids under the presidency of by Professor Jan Frederik Stevens, Oregon State University, USA.

Professor Andreas Schieber, President of Polyphenols Applications, University of Bonn, Germany, stated: "Polyphenols Applications 2022 will shed light on the most recent discoveries and blooming topics":

Microbiota, metabolites, adipose tissuenervous systemsenolytic activityageingendothelial functionradioprotection, oxidative stress, ferroptosis, cancer, atherosclerosisextracellular vesiclescannabinoids, cannabinoid receptors, anticancer activity, antiviral activity, anti-dyslipidemic effect, ocular delivery, cosmetic application, polyphenols recovery, extraction, valorization, fermentation, wine polyphenolssensory aspects, inter-individual variability...

More than 300 international participants will be attending in-person and online, and more than 70 communications will be presented during the conference.

Among important companies that will be joining: Silvateam, Bioquochem, ElderCraft, IPRONA, Canurta Inc., Ajinomoto OmniChem NV, Layn USA, and many others.

Abstract Submission

  • Short Oral Presentation submission deadline: September 5
  • Poster Presentation submission deadline: September 12

More details on abstract submission

Access to Cannabis & Cannabinoids Workshop

More information about the workshop sessions. 

Registration for workshop or workshop & congress

Registration

You can register for in-person or online participation. Registration details

Early bird registration deadline: August 10.

Don't hesitate to contact us for more information.


Polyphenols Applications 2022 Congress
September 28-30, 2022
ADEIT, Valencia, Spain & Online

www.polyphenols-site.com

Call for Abstracts & Innovations

Polyphenols Applications - Call for Abstracts

This call is addressed to all the scientists, academics, and industrials working on polyphenols!

The Scientific Committee of Polyphenols Applications 2022 are pleased to invite you to present your most recent findings on polyphenols this September - during the 15th World Congress on Polyphenols Applications.

Abstract Submission Deadline:

  • Deadline for Short Oral Submission: September 5, 2022
  • Deadline for Poster Submission: September 12, 2022

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Sensory Aspects of Polyphenols in Polyphenols Applications 2022

Polyphenols Applications 2022 new session on the "Sensory Aspects of Polyphenols" will cover the most recent research in the field. International professionals will be presenting their latest results. Talks to be presented in the session:

Chemical and Sensory Evaluation of Astringency Modulation in Red Wine
Fabian Weber, University of Bonn, Germany
 
Discoloration Caused by Interactions Between Flavonoids and Iron
Jean-Paul Vincken, Wageningen University & Research, The Netherlands
 
Molecular Perception of Astringency & Bitter Taste of Tannins in Food
Susana Soares, Faculdade de Ciências da Universidade do Porto (FCUP), Portugal
 
Ion Mobility–Mass Spectrometry in Food Analysis
Sonia Sentellas, University of Barcelona, Spain
 
Polyphenol-Protein Interactions - Still Many Challenges to Cope With...
Sascha Rohn, Technische Universität Berlin, Germany
 
You can get introduced to other coference sessions and speakers here.

 
 
polyphenols valenciaPolyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Polyphenol-Protein Interactions - Still Many Challenges to Cope With...

Polyphenols 2022 Speakers -  Sascha RohnDr. Sascha Rohn, Technische Universität Berlin, Germany, will join us this year to present a talk entitled “Polyphenol-Protein Interactions - Still Many Challenges to Cope With...”

More and more researchers are dealing with the characterization of interactions of polyphenols with other food ingredients. In this ocasion, proteins are interesting, as they can interact (non-covalently), but als form (covalent) reactions products, highly depending on the interaction/reaction conditions, as well as on the initial properties of the polyphenols and the proteins. Cosequently, interaction and reaction products might affect technofunctional and physiological properties (of the corresponding foods) as well. One can even think of covalent polymeric reaction products that affect color, solubility and lead to unrevealed nutritional consequences. Overall, this is a bunch of complex challenges that need to be considered.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Rohn.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Innovative Processes for Berry Juice Production and Side Stream Valorization

Polyphenols 2022 Speakers - Ms. Nicole Nemetz, University of Bonn, Germany, will join Polyphenols Applications 2022 to present recent advances on the "Innovative Processes for Berry Juice Production and Side Stream Valorization".

She will talk about strategies for the optimization of the juice production (use of ultrasoud) as well as about the recovery of berry pomace in the food industry (seed oil, coloring foodstuff, fruit bars, granola).

Join us in Polyphenols Applications 2022 to know more about the technological innovations in polyphenols extraction and valorization.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Gut Microbial Metabolism of Dietary Polyphenols in Health and Disease

Polyphenols 2022- Jan ClaesenDr. Jan Claesen, from Cleveland Clinic, USA, will join us this year to present a talk entitled “Gut Microbial Metabolism of Dietary Polyphenols in Health and Disease” in a session dedicated to “Polyphenols & Microbiota – Recent Advances & Perspectives”.

Flavonoids are consumed in a largely glycosylated form, rendering them poorly available for small intestinal absorption and subsequent systemic distribution. Upon reaching the colon, select commensal gut bacteria can catabolize these flavonoid substrates into smaller monophenolic acids.

In his talk, Dr. Claesen will discuss the contribution of microbial catabolism to the beneficial effects of dietary flavonoids in health and in disease. 

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Claesen.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

 

Evaluation of Microstructure and Green Extraction Methodologies for Recovering Polyphenols From Sweet Potato Peel

Polyphenols 2022 Speakers -  2Dr. Juan Manuel Castagnini, from the University of Valencia, Spain, will join us this year to present a talk entitled “Evaluation of Microstructure and Green Extraction Methodologies for Recovering Polyphenols From Sweet Potato Peel”.

The re-use of by-products from food processing and their re-introduction in the production cycle is a strategy that is worth considering for the development of a more sustainable food industry. Although many actors and industrial sectors could help to tackle the limitation of the traditional food system approach, researchers can contribute by innovations able to create a better and more nutritious diet and a sustainable food system. In this sense, the recovery of bioactive compounds from by-products using innovative non-thermal green technologies is an interesting approach to develop new ingredients and products.

Purple and orange sweet potato peel could be an interesting source of bioactive compounds. In this study, through pulsed electric field assisted extraction and supercritical solvent extraction different extracts were obtained and characterized. Also, the microstructure of the solids residues recovered after extraction were analysed to better understand the effect of extraction processes on the matrix.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Castagnini.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Discoloration Caused by Interactions Between Flavonoids and Iron

Dr. Jean-Paul VinckenDr. Jean-Paul Vincken, from Wageningen University & Research, The Netherlands, will join us this year to present a talk entitled “Discoloration Caused by Interactions Between Flavonoids and Iron”.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Vincken.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Chemical and Sensory Evaluation of Astringency Modulation in Red Wine

Polyphenols 2022 Speakers - Fabian WeberDr. Fabian Weber, University of Bonn, Germany, will join Polyphenols Applications 2022. He will give a talk on the "Chemical and Sensory Evaluation of Astringency Modulation in Red Wine".

Besides the color, the mouthfeel and astringency are the most relevant quality aspects of red wine. Anthocyanins are the coloring principle and tannins are the key compounds for astringency.

Both compounds are extracted from the grapes during winemaking and both compounds are subjected to extensive structural changes during wine ageing. The corresponding reactions that lead to a stable color and an attenuated astringency are closely related and are affected by the wine matrix.

The goal of Dr. Weber's study was to understand the role of polysaccharides in grapes and wine regarding the formation of polymeric pigments and the masking of astringency.

Join the congress this June in Valencia & Online to learn more about the sensory properties of polyphenols in different matrices.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Beneficial Health Effects of Polyphenol-Rich Fruit Juice in Humans

Polyphenols 2022 Speakers - Prof. Elke RichlingProf. Elke Richling, University of Kaiserslautern, Germany, will join Polyphenols Applications 2022 to present recent advances on the "Beneficial Health Effects of Polyphenol-Rich Fruit Juice in Humans".

In vitro and in vivo studies provide evidence that polyphenol-rich fruit juices and their extracts can influence lipid metabolism as well as improve DNA integrity.

To substantiate preliminary findings, Prof. Richling and her team performed a placebo-controlled intervention study with 36 male healthy subjects (age 20–40 years, body mass index 19–25 kg/m2). After one week washout period, the volunteers consumed 750 mL/day of a polyphenol-rich fruit juice (containing chokeberry, cranberry, and pomegranate) or placebo drink for eight weeks. Blood sampling was performed after the washout period as well as after four and eight weeks of intervention and used to analyse biomarkers of the lipid metabolism like blood platelet cyclic adenosine monophosphate phosphodiesterase (cAMP-PDE) activity. In addition, effects on DNA strand breaks and on body weight/composition were monitored.

The results showed a significant inhibition of cAMP-PDE activity (p<0.01) and decrease in DNA strand breaks (p<0.05) during juice consumption. Consuming juice, an increased fat-free mass (p<0.05) was found after four weeks, whereas a significant (p<0.05) elevation in body weight was observed in control group.

Taken together their results indicate health beneficial effects associated with polyphenol-rich fruit juice consumption.

Join us in Polyphenols Applications 2022 to know more about these findings and many more topics.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Gas Chromatography-Mass Spectrometry Analysis of Cannabinoids: Chemical Diversity Across a Range of Feral Cannabis Plants

Dr. Luke BustaDr. Luke Busta, from University of Minnesota Duluth, USA, will join us this year to present a talk entitled “Gas Chromatography-Mass Spectrometry Analysis of Cannabinoids: Chemical Diversity Across a Range of Feral Cannabis Plants”. He will be participating in the Polyphenols Cannabis workshop on September 30, 2022.

Gas chromatography-mass spectrometry (GC-MS) is a widely accessible technique that can provide considerable analytical information.

Here, Dr. Busta develops a relatively high-throughput method for cannabinoid analysis using GC-MS and use that method to assess cannabinoid diversity across 28 feral cannabis plants.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Luke Busta.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Methods of Quantitative Analysis for Cannabinoids in Industrial Hemp

Dr Jennifer DuringerDr. Jennifer Duringer, from Oregon State University, USA, will join us this year  in the Polyphenols Cannabis Workshop to present a talk entitled “Methods of Quantitative Analysis for Cannabinoids in Industrial Hemp”. 

Quantitative measurement of cannabinoids in industrial hemp is important for both regulatory and research purposes as researchers begin to uncover the potential of Cannabis and its products for human and animal health. Sample collection, preparation, extraction and analytical detection (LC-DAD and LC-MS/MS) will be discussed along with best practices for quality assurance/quality control.”

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Jennifer Duringer.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

The Challenge of Modulating the Gut Microbiota with Polyphenols in Metabolic Syndrome Patients

Polyphenols 2022 Speakers Juan Carlos EspinProf. Juan Carlos Espín, from the Spanish National Research Council, Spain, will join us this year to present a talk entitled “The Challenge of Modulating the Gut Microbiota with Polyphenols in Metabolic Syndrome Patients”.

Metabolic syndrome (MetS) is a group of metabolic traits that increase the risk of cardiovascular disease. These patients usually show a gut microbiota in dysbiosis, and thus, targeting the gut microbiota has been proposed to improve MetS traits. However, both MetS and gut dysbiosis are often misunderstood terms.

Prof. Espín's talk will overview the complex binomial MetS-gut microbiota and illustrate the challenge of modulating this so-called gut dysbiosis with a pomegranate-rich polyphenols extract in a randomized, placebo-controlled double-blind clinical trial in MetS patients under poly-pharmacological treatment.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Towards the Utilization of Cannabinoids as Anticancer Agents

Polyphenols Applications 2022 - Dr. Guillermo VelascoDr. Guillermo Velasco, from Instituto de Investigación Sanitaria San Carlos, Spain, will join us this year to present a talk entitled “Towards the Utilization of Cannabinoids as Anticancer Agents”.

A large body of evidence shows that cannabinoids, in addition to their well-known palliative effects on some cancer-associated symptoms, can reduce tumour growth in animal models of cancer and specifically of gliomas. The mechanism of cannabinoid anticancer action relies, at least largely, on the ability of these agents to stimulate autophagy-mediated cancer cell death. Moreover, the combined administration of cannabinoids and temozolomide produces a strong anticancer effect, which correlates with an intense activation of the signalling route that triggers the activation of cytotoxic autophagy.

Research conducted in Dr. Velasco's group has also led to the identification of mechanisms of resistance to cannabinoid anticancer action. For example, up-regulation of the growth factor Midkine (MDK) promotes resistance to cannabinoid anticancer action in gliomas via stimulation of the Anaplastic Lymphoma Kinase tyrosine kinase receptor (ALK); and could be a factor of bad prognosis in GBM patients. All these preclinical findings have facilitated the promotion of clinical studies to investigate the safety and efficacy of the combined administration of THC+CBD and temozolomide in GBM.

In this presentation Dr. Velasco will briefly discuss these issues and other possible future studies that may help to clarify whether cannabinoids may be useful as anticancer agents in patients with gliomas or other cancers.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Velasco.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Inhibition Mechanism of Catechins on Dietary AGEs Absorption and Toxicity

Dr. Qian Wu updatedDr. Qian Wu, from Hubei University of Technology, China, will join us this year to present a talk entitled “Inhibition Mechanism of Catechins on Dietary AGEs Absorption and Toxicity”.

In her study, using a simulated gastrointestinal digestion model, Dr. Wu showed that catechin efficiently inhibited the digestion of oligopeptide-AGEs. A mass-spectrometry- (MS) based proteomics approach (Q Exactive) was applied to identify the digestion products of glycated bovine serum albumin (BSA), and three oligopeptide-AGEs was found, including FWGK(160)-CML, LSQK(245)FPK-CML, WSVAR(221)LG-H1. No free AGEs were detected indicated that the digested glycated protein existed in the form of oligopeptide-AGEs. Addition of catechin as inhibitor, a significant decline in the fluorescence intensity of glycated protein, the degree of hydrolysis and free amino acids were observed and the particle size of the digestion products increased, which could indicate the inhibitory effects of catechin on the release of AGEs during gastrointestinal digestion.

Using Caco-2 cell model, we found that catechins could effectively inhibit the absorption of oligopeptide-AGEs and the expression of oligopeptide-transportor (PEPT1) and tight junction protein (ZO-1). The expression of ZO-1 in Caco-2 cells could be determined by immunohistochemical staining, and the results suggested that adding catechin could significantly increase the expression of ZO-1 (P< 0.05). Caco-2 cells were induced with BSA-AGEs digests for 24 h, and it was indicated that 20 µm and 50 µm catechins could reduce the expression of PepT1 by 53.8% and 73.1%, respectively (P< 0.01). In addition, molecular docking method was used to compare the binding ability of catechin to three oligopeptides-AGES (FWGK(160)-CML, LSQK(245)FPK-CML, WSVAR(221)L-G-H1) and PepT1, and it was found that catechin was easier to bind to PepT1. Therefore, the transport capacity of PepT1 to oligopeptide-AGEs was decreased.

It was found that the activation of RAGE receptor in rat liver were inhibited and the liver damage caused by dietary AGEs were reduced by catechin in rat model. SPF Rats were divided into four groups: normal diet (N), high-dose AGEs diet (H), 0.2% catechin supplemented diet (0.2%) and 0.5% catechin supplemented diet (0.5%), respectively. The expressions of RAGE, p38MAPK and NF-κB in the liver of the rats were detected by immunochemistry staining. The results showed that the activation of RAGE-p38MAPK-NF-κB signaling pathway was significantly inhibited by 0.5% catechin (p<0.01).The expressions of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) genes in liver were detected by RT-PCR, and the results showed that the expression of inflammatory cytokines could be significantly decreased by 0.2% and 0.5% catechin.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Wu.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Effects of Berry (Poly)phenols on Cardiovascular Health: Clinical Evidence and Mechanistic Insights

Dr. Ana Rodriguez-Mateos-v1Dr. Ana Rodriguez-Mateos, from King's College London, United Kingdom, will join us this year to present a talk entitled “Effects of Berry (Poly)phenols on Cardiovascular Health: Clinical Evidence and Mechanistic Insights”.

Berries are getting increased attention due to their potential cardiovascular health benefits. However, which bioactives in berries are responsible for the effects and the mechanisms of action in the vascular system are currently unknown. Dr. Rodriguez-Mateos will discuss the recent clinical studies she has conducted investigating the effect of different berries and berry (poly)phenol extracts on cardiovascular function. You can find more information on Dr. Rodriguez-Mateos research here.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Rodriguez-Mateos.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Polyphenols and Extracellular Vesicles: A New Revolution?

Dr. Ramaroson AndriantsitohainaDr. Ramaroson Andriantsitohaina, from France, will join us this year to present exclusively and for the first time a talk on “Polyphenols and Extracellular Vesicles: A New Revolution?”.

Extracellular vesicles have been well reported as a novel mean of cell-to-cell communication in physiology and pathology. 

Dr. Andriantsitohaina was recently the first to prove that polyphenols can act on signaling pathways that interfere with the EVs biogenesis (release and content), and are thus able to control cells' functional properties. 

He points out that the combination of polyphenols and EVs can increase their therapeutic potential, for instance:

  1. Plants are able to produce EVs that encapsulate natural components from vegetables, polyphenols for instance
  2. Mammalian cells can be treated with polyphenols and the subsequent EVs produced are enriched in these components
  3. EVs from mammalian cells can be uploaded with polyphenols. 

Join us in Polyphenols Applications 2022 and be the first to listen to Dr. Andriantsitohaina review the novel aspects of the interplay between polyphenols and EVs and its potential health benefits in cancer, cardiovascular, metabolic and neurodegenerative diseases. 

Don't miss the chance! Book your spot.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Wine Polyphenols and Gut Microbiota

Polyphenols 2022 - Nenad NaumovskiDr. Nenad Naumovski, from University of Canberra, Australia, will join us this year to present a talk entitled “Wine Polyphenols and Gut Microbiota”.

This presentation will include the latest findings from observational studies relating to the wine consumption and its effect on gut microbiota. Furthermore, Dr. Naumovski will also discuss the consumption of wine polyphenols and their implications in health.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr.  Naumovski.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Conversion of Phenolic Compounds in Food Fermentations by Lactic Acid Bacteria: Metabolic Pathways and Functional Metabolites

Dr. Michael Ganzle-v1Dr. Michael Gänzle, from the University of Alberta, Canada, will join us this year to present a keynote presentation on “Conversion of Phenolic Compounds in Food Fermentations by Lactic Acid Bacteria: Metabolic Pathways and Functional Metabolites”.

Dr. Gänzle's presentation will present current knowledge on metabolic pathways for conversion of phenolic compounds by lactic acid bacteria, and indicate which conversions have been described in food fermentations.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Gänzle.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Molecular Taste: Molecular Approaches to Understand Food Polyphenols Astringency and Bitterness

Dr. Susana SoaresDr. Susana Soares, from Faculdade de Ciências da Universidade do Porto (FCUP), Portugal, will join us this year to present a talk entitled “Molecular Taste: Molecular Approaches to Understand Food Polyphenols Astringency and Bitterness".

As per Dr. Soares, phenolic compounds (PC) are linked to astringency sensation and bitter taste. Regarding astringency, studies typically use simple models, with pure PC and/or proteins, far from what is likely to occur in the oral cavity. Different oral models have been developed in our last works, comprising different oral epithelia (buccal mucosa (TR146) and tongue (HSC-3)) and other main oral constituents (human saliva and mucosal pellicle). These models have been used to study the interaction with more or less complex PC extracts as well as with food matrices, such as coffee. The studied extracts were rich in different families of (food) PC, namely flavanols (a green tea extract), anthocyanins (a red wine extract), gallotannins (a tannic acid extract), and flavonols (an onion extract). It was observed a different interaction for the different families of PC and also that the several oral constituents have different implications. Moreover, some of these studies aligned the in vitro models with sensory studies data. Overall, the results seem to point out that the different oral constituents can have different functions in astringency perception as well as being involved in different phases of astringency perception. These differences can be related to the perception of different astringency sub-qualities.

Regarding bitterness, Dr. Soares and her team have used a cell-based assay to screen which human bitter taste receptors are activated by a library of PC from different families. The bitter taste receptors (TAS2Rs) activated by these polyphenols and the half-maximum effective concentration (EC50) of each agonist-TAS2Rs pair were determined. TAS2R5 seems to be the only receptor somehow “specifically” activated by natural (condensed) tannins, while TAS2R7 seems more tuned for hydrolysable (ellagi)tannins. Additionally, at the concentrations usually found for these compounds in foodstuffs, they can actively contribute to bitter taste, especially ETs. Ultimately, it seems that when considering the bitterness of polyphenols, bitterness and astringency sensory properties seem to be undeniably linked, especially to explain and compare in vitro and in vivo inconsistencies.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Soares.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Polyphenols in the News & Media

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