The Potential of Polyphenols in the Context of Senotherapy

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Alessandra Gambero 1Dr. Alessandra Gambero, from Pontifical Catholic University of Campinas, Brazil, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

She will present her latest research on the Potential of Polyphenols in the Context of Senotherapy. 

Learn more about her findings.

Presentation Summary

  • Cellular senescence is characterized by a stable cell proliferation arrest and the establishment of a secretory phenotype in normal cells in response to intrinsic and extrinsic stimuli.
  • Cellular senescence is associated with chronological aging and a response to environmental stressors.
  • Expanded knowledge about the role of senescence in the physiological context and disease processes and development of drugs that can counteract the harmful effects of cellular senescence as a therapeutic target.
  • Therefore, senotherapeutics can be classified as senolytics drugs that selectively eliminate senescent cells or senostatics (senomorphic) that inhibit, reverse, or prevent aspects associated with cellular senescence.
  • The most studied option combines dasatinib and quercetin, a natural polyphenol that targets BCL-2 and PI3K/AKT signaling pathways.
  • The various pharmacological mechanisms described for polyphenols suggest that others may have senotherapeutic effects, which has been the focus of our recent work.

About Alessandra Gambero

Graduated in Biological Sciences from Paulista State University Júlio de Mesquita Filho (1994), Master in Biological Sciences (Pharmacology) from Paulista State University Júlio de Mesquita Filho (1997), PhD in Pharmacology from University of São Paulo (2001), and Post-doctoral at Paul Sabatier University (Toulouse, France). Currently develops projects in the research area of Aging and cellular senescence, Foods with health claims, and Regenerative Medicine and Innovation in Health.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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