Nestlé Research Wins First Best Poster Presentation at Polyphenols Applications 2024
Dr. Laure Poquet of Nestlé Research has been awarded the Best Poster Presentation (1) at Polyphenols Applications 2024 for her outstanding research on oleuropein metabolites.
Her poster, “Oleuropein Metabolites Are Biologically Active as Mitochondrial Calcium Activators at the Concentration Measured in Human Plasma,” highlighted the bioactivity of these metabolites derived from olive leaf extracts.
The study demonstrated that, at concentrations measurable in human plasma, these metabolites can activate mitochondrial calcium, leading to enhanced energy metabolism in muscle cells.
A new study was performed by Nestlé scientists to understand how the polyphenols from olive leaf extract can boost muscle energy. The main natural polyphenolic compound of this extract is oleuropein. Its metabolites circulating in plasma after intake were detected and quantified using a validated LC-MS/MS method. Their potential biological activities as mitochondrial activators were tested in vitro, at the circulating concentrations. The results showed that, although the level of oleuropein was low, its metabolites are biologically active in skeletal muscle cells and reach a total concentration in human blood sufficient to activate mitochondrial energy metabolism via mitochondrial Ca2+ activation.
This achievement marks a significant step in understanding the role of oleuropein in improving muscle function and supporting healthy aging. Congratulations to Dr. Poquet on this well-deserved recognition!
