Anthocyanins and cellular redox signaling: Nrf2 and NF-kB as targets

Pr. Francesco Cimino from the University of Messina, Italy, will talk about Anthocyanins and cellular redox signaling: Nrf2 and NF-kB as targets at Porto Polyphenols World Congress.

According to Pr. Cimino, reactive oxygen species (ROS) serve important physiological functions in host defense, and constitute an important second messenger in cell signaling transduction, but several chronic pathological conditions are associated with a status of oxidative stress, that is an unbalance between ROS formation and antioxidant availability. Many plant antioxidants, have been shown able to prevent free radical-related diseases by counteracting cell oxidative stress. However it is now considered that the in vivo beneficial effects of these phytochemicals are unlikely to be explained just by their antioxidant capability.

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