Angiogenesis as a Target of Dietary (Poly)phenols and Derived Metabolites

Juan A. Giménez-Bastida 3 1It is a great pleasure to welcome Dr. Juan A. Giménez-Bastida, CEBAS-CSIC, Spain, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Angiogenesis as a Target of Dietary (Poly)phenols and Derived Metabolites.

Presentation Summary

  • Emphasis on the utilization of natural compounds, particularly (poly)phenols, as a promising avenue for regulating angiogenesis.
  • Objective: Provide comprehensive insights into the specific molecules capable of modulating angiogenic processes and elucidate the mechanisms through which these effects are realized.
  • Findings from preclinical investigations demonstrated the efficacy of tested (poly)phenols, whether identified in the bloodstream or systemic tissues, in modulating key in vitro angiogenesis processes.
  • Potential for transitioning from in vitro models to in vivo studies to further validate the efficacy and safety of (poly)phenols in regulating angiogenesis.

About Juan A. Giménez-Bastida

Juan A. Giménez-Bastida was awarded with a Juan de la Cierva Fellowship to work at CEBAS-CSIC. The results obtained described novel roles of urolithins as pro-senescence molecules against cancer cells and new anti-inflammatory effects (targeting 5-LOX pathway) in leukocytes. The excellent results at the completion of this fellowship are reflected by 7 publications in high-impact factor journals and the obtained funding within the European Marie Curie program. 
Dr. Giménez-Bastida is now the project coordinator of the EU-funded PolyBiota project. This project investigates the role of the gut microbiota as a mediator of the beneficial effects associated with the consumption of ellagitannins and(or) isoflavones-rich diets. To accomplish the objectives, the PolyBiota project shows an innovative approach  combininig cutting edge technologies, "big data" management as well as in vitro and in vivo models providing a holistic scene of the Diet-Gut microbiota-Host interaction.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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