How Resveratrol could have beneficial effects in Inflammation Diseases? will be presented by Dr Pautz at the Malta Polyphenols World Congress 2015 on June 3-5

“Resveratrol shows beneficial effects in inflammation-based diseases like cancer, cardiovascular and chronic inflammatory diseases. Therefore the molecular mechanisms of the anti-inflammatory resveratrol effects deserve more attention. We demonstrated that resveratrol decreased the expression of different important pro-inflammatory mediators, such as TNF-a, by reducing mRNA stability without significant inhibition of the respective promoter activity. Target-fishing and drug responsive target stability experiments showed selective binding of resveratrol to the RNA-binding protein KSRP, which is a central post-transcriptional regulator of pro-inflammatory gene expression. In accordance, knockdown of KSRP expression diminished the post-transcriptional effects of resveratrol on pro-inflammatory gene expression. Further experiments revealed that resveratrol enhances the activity of KSRP protein by reducing a p38 MAPK-related inhibitory KSRP threonine phosphorylation, without blocking p38 MAPK activation or activity. Therefore modulation of KSRP activity and thereby enhancement of mRNA degradation seems to be the common denominator of many anti-inflammatory effects of resveratrol.” During the talk, Dr. Pautz will detail how Resveratrol controls pro-inflammatory mediators by modeling the post-transcription process.

To know more about the Malta Polyphenols World Congress 2015 that will be held on June 3-5 in Malta and the preliminary agenda, please visit www.polyphenols-site.com.