Anthocyanins Attenuate High‐Fat Diet‐Induced Colonic Barrier Dysfunction and Inflammation by Modulating the Gut Microbiota

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The organizing committee of Polyphenols Applications 2021 Congress would like to share this excellent paper by Baoming Tian and al. on Anthocyanins Attenuate High‐Fat Diet‐Induced Colonic Barrier Dysfunction and Inflammation by Modulating the Gut Microbiota.

In this study, they showed that Lycium ruthenicum anthocyanins (ACs) reduce weight gain; improve high‐fat diet‐induced gut microbiota dysbiosis; significantly enrich short‐chain fatty acid (SCFA)‐producing bacteria, increase SCFA content, and SCFA receptor expression; and decrease endotoxin‐producing bacteria and endotoxin levels in the gut. The results reveal ACs attenuate high‐fat diet‐induced colonic barrier dysfunction and inflammation by modulating the gut microbiota in mice. 

Gut barrier dysfunction and inflammation originating from a dysbiotic gut microbiota (GM) are strongly associated with a high‐fat diet (HFD). Anthocyanins from Lycium ruthenicum (ACs) show antiobesity effects through modulating the GM. However, the mechanism linking the antiobesity effects of ACs and GM modulation remains obscure.

They indicated that ACs can mitigate colonic barrier dysfunction and inflammation, induce SCFA production and inhibit endotoxin production by modulating the GM in HFD‐fed mice. This finding provides a clue for understanding the antiobesity effects of ACs.

One of the Hot Topic of Polyphenols Applications 2021 Congress is Microbiota and Polyphenols. For more information: https://polyphenols-site.com/


Article source: https://doi.org/10.1002/mnfr.202170017
Authors: Baoming Tian, Jianhua Zhao, Min Zhang, Zhifei Chen, Qingyu Ma, Huicui Liu, Chenxi Nie, Ziqi Zhang, Wei An, Juxiu Li 
Mol. Nutr. Food Res. 2021, 65, 2000745
DOI: 10.1002/mnfr.202000745

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