Non-estrogenic xanthohumol derivatives improve cognitive function in diet-induced obese mice

Jan Frederik Stevens - vienna Polyphenols 2018Prof. Fred Stevens from Oregon State University, Corvallis, USA will talk about "Non-estrogenic xanthohumol derivatives improve cognitive function in diet-induced obese mice" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 26-28, 2018.

According to Prof. Stevens:

Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its biotransformation by gut microbiota into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in humans. To address this concern, we evaluated two hydrogenated derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), which showed negligible affinity for estrogen receptors α and β, and which cannot be metabolically converted into 8-PN. Diet-induced obese mice administered XN, DXN or TXN showed improvements of impaired glucose tolerance compared to the controls. DXN and TXN treatment resulted in a decrease of HOMA-IR and plasma leptin. XN, DXN, or TXN treatment ameliorated diet-induced deficits in spatial learning and memory.


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