Why biotransformation matters: species differences in isoflavone metabolism and biological implications

Dr. Sebastian Soukup from the Max Rubner-Institut, Germany will discuss the topic "Why biotransformation matters: species differences in isoflavone metabolism and biological implications" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

Summary of talk: "Isoflavones are associated with beneficial health effects such as the alleviation of menopausal symptoms and the prevention of osteoporosis, but are also discussed to have proliferative effects on ER-sensitive breast cancer.
To investigate physiological effects of bioactive compounds, animals models are widely used. Since species differences in metabolism can lead to changes in bioactivity and biokinetic behaviour of the compounds investigated, they have to be considered when extrapolating results to the human situation. In this presentation, analytical aspects of biotransformation studies as well as recent findings about isoflavone metabolism in different animal models and humans will be outlined and their biological implications discussed."  

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