Spain Polyphenols Applications is postponed to 2021

Dear Colleagues,

 

In response to the critical situation and evolution of the COVID-19, the Organizing Committee of Polyphenols Applications 2020 decided to postpone the congress to next year.

 

We will announce the details as soon as the planning of the 2021 meeting has been completed.

 

We will keep your registration, you don’t need to do anything.  In case of cancellation, the Organizing Committee will fully refund you.
Thank you for your understanding of this exceptional situation.

 

We will keep our optimism and wish rapidly to overcome these moments.

 

All our warm regards,

 

Prof. Dr. Andreas Schieber                      
President of Polyphenols Applications 2020
University of Bonn, Germany 

 

Researchers explore anti-inflammatory activity of curcumin

1-researcherseCredit: iStock


The spice turmeric, with its active polyphenol curcumin, has been used as anti-inflammatory remedy in traditional Asian medicine for centuries. Many cellular targets of curcumin have been identified, but how such a wide range of targets can be affected by a single compound is unclear. Here, we identified curcumin as a pro-drug that requires oxidative activation into reactive metabolites to exert anti-inflammatory activities. Synthetic curcumin analogs that undergo oxidative transformation potently inhibited the pro-inflammatory transcription factor nuclear factor κB (NF-κB), whereas stable, non-oxidizable analogs were less active, with a correlation coefficient (R2) of IC50 versus log of autoxidation rate of 0.75. Inhibition of glutathione biosynthesis, which protects cells from reactive metabolites, increased the potency of curcumin and decreased the amount of curcumin-glutathione adducts in cells. Oxidative metabolites of curcumin adducted to and inhibited the inhibitor of NF-κB kinase subunit β (IKKβ), an activating kinase upstream of NF-κB. An unstable, alkynyl-tagged curcumin analog yielded abundant adducts with cellular protein that were decreased by pretreatment with curcumin or an unstable analog but not by a stable analog. Bioactivation of curcumin occurred readily in vitro, which may explain the wide range of cellular targets, but if bioactivation is insufficient in vivo, it may also help explain the inconclusive results in human studies with curcumin so far. We conclude that the paradigm of metabolic bioactivation uncovered here should be considered for the evaluation and design of clinical trials of curcumin and other polyphenols of medicinal interest.

News source: www.phys.org

Authors: Rebecca L. Edwards‡, Paula B. Luis‡1, Paolo V. Varuzza‡, Akil I. Joseph‡, Sai Han Presley‡, Rupesh Chaturvedi§2 and Claus Schneider‡