Piceatannol in Senotherapeutics


News release, Polyphenols Applications - 30 March 2022, Valencia - Spain

Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing senescent cells and/or preventing their accumulation within tissues.

Using polyphenols in counteracting senescence may facilitate the development of senotherapeutics given their presence in the human diet, their confirmed tolerability and absence of severe side effects, and their role in preventing senescence and inducing the death of senescent cells.

A team evaluated the effect of piceatannol, a natural polyphenol, on the senescence of mesenchymal stromal cells (MSCs), which play a key role in the body’s homeostasis.

Interestingly, their findings showed that piceatannol reduced the number of senescent cells both after genotoxic stress that induced acute senescence and in senescent replicative cultures. Such senotherapeutics activity, moreover, promoted the recovery of cell proliferation and the stemness properties of MSCs.

Moreover, they demonstrated piceatannol’s effectiveness in counteracting senescence by targeting its associated pathways and detecting and affecting P53-dependent and P53-independent senescence.

Overall, their study suggests that, given piceatannol’s various mechanisms to accomplish its pleiotropic activities, it may be able to counteract any senescent phenotypes.

All polyphenols innovations as well as the senotherapeutic aspects of polyphenols will be discussed during the 15th World Congress on Polyphenols Applications.

To read the full article.

Photo credit:  jcomp - www.freepik.com

Media Contact:
Polyphenols Applications Team
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Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain


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