Rutin alleviates colon lesions and regulates gut microbiota in diabetic mice

Rutin alleviates colon lesions and regulates gut microbiota in diabetic mice 1

News release, Polyphenols Applications - March 28, 2023

Diabetes is a common metabolic disorder that has become a major health problem worldwide. Cai et al. investigated the role of rutin in attenuating diabetes and preventing diabetes-related colon lesions in mice potentially through regulation of gut microbiota.

The rutin from tartary buckwheat as analyzed by HPLC was administered intragastrically to diabetic mice, and then the biochemical parameters, overall community structure and composition of gut microbiota in diabetic mice were assayed.

The results showed that rutin lowered serum glucose and improved serum total cholesterol, low-density lipoprotein, high-density lipoprotein, triglyceride concentrations, tumor necrosis factor-α, interleukin-6, and serum insulin in diabetic mice. Notably, rutin obviously alleviated colon lesions in diabetic mice.

Moreover, rutin also significantly regulated gut microbiota dysbiosis and enriched beneficial microbiota, such as Akkermansia. Rutin selectively increased short-chain fatty acid producing bacteria, such as Alistipes and Roseburia, and decreased the abundance of diabetes-related gut microbiota, such as Escherichia and Mucispirillum.

Thus, rutin exerted an antidiabetic effect and alleviated colon lesions in diabetic mice possibly by regulating gut microbiota dysbiosis, which might be a potential mechanism through which rutin alleviates diabetes-related symptoms.

Article DOI.

Image Credits: Cai et al. Sci Rep (2023).

Polyphenols Applications 2023 will elaborated on the important role of polyphenols in health and in disease. You can learn more about the conferece program here.

Media Contact:
Polyphenols Applications Team
This email address is being protected from spambots. You need JavaScript enabled to view it.

Polyphenols Applications 2023 Congress
September 27-29, 2023 - Malta
Website | LinkedIn | Facebook

Polyphenols in the News & Media

  • 1
  • 2
  • 3
Prev Next
Polyphenols Buttons-all news-v1