News Alert
Polyphenol-Microbiome Interactions & Future of Nutrition
Dr. Tiffany Weir, Colorado State University USA, will join the Polyphenols Applications 2023 Congress and present her latest rearch about the interactions between polyphenols and the microbiome.
Although consumption of dietary polyphenols is widely acknowledged as beneficial for human health, there is a high degree of variability in individual responses. Some of this variability may be due to differential processing of dietary polyphenols by the gut microbiome. Polyphenol metabolizing enzymes in the gut microbiota can influence the bioactivity and bioavailability of these compounds.
Dr. Weir and her colleagues are working to understand whether these polyphenol metabolizing enzymes are predictive of individual responses in vascular endothelial function to a dietary blueberry intervention in post-menopausal women. More broadly, understanding polyphenol metabolism in the gut will advance precision nutrition and potentially help identify complementary approaches to improve outcomes to nutrition interventions.
Dr. Weir will give a presentation titled: "Polyphenol-Microbiome Interactions & Future of Nutrition"
About Dr. Weir
Dr. Tiffany Weir is a professor of Food Science and Human Nutrition at Colorado State University. She leads an interdisciplinary translational research program focused on identifying the role of the gut microbiota in mediating diet-host interactions for improved cardiometabolic outcomes. Dr. Weir is the coordinator of the Microbiome Network, an interdisciplinary research and education consortium of microbiome scientists at Colorado State University. She also served as the Specialty Chief Editor for the Nutrition, Metabolism, and Microbiomes section of Frontiers in Microbiomes and is currently the Editor-in-Chief for npj Biofilms and Microbiomes.
Join us in Polyphenols Applications 2023 to learn more about Prof. Weir's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Polyphenols & Immunomodulation: What do we know?
Prof. Hanne Frøkiær, University of Copenhagen, Denmark, will join the Polyphenols Applications 2023 Congress and present her latest rearch about the "Polyphenols & Immunomodulation: What do we know?".
Join us in Polyphenols Applications 2023 to learn more about Prof. Frøkiær's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Role of Polyphenolic Caffeoylquinic Acids in the Neurological Effects of Centella asiatica
Dr. Amala Soumyanath, Oregon Health & Science University, USA, will join the Polyphenols Applications 2023 Congress and present his latest rearch about the "Role of Polyphenolic Caffeoylquinic Acids in the Neurological Effects of Centella asiatica".
The traditional herbal remedy, Centella asiatica, shows remarkable effects related to cognitive function and mood in preclinical models. Its abundant triterpene constituents are usually reported as the active compounds.
However, studies conducted by Dr. Soumyanath and her colleagues, show that polyphenolic caffeoylquinic acid isomers also play an important role in this herb’s neurotropic effects in vitro and in vivo.
Join us in Polyphenols Applications 2023 to learn more about this topic.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Deglycosylation of secondary plant metabolites by lactobacilli
Prof. Michael Gänzle, University of Alberta, Canada, will join the Polyphenols Applications 2023 Congress and present his latest rearch about the "Deglycosylation of secondary plant metabolites by lactobacilli".
Lactobacillaceae are among the major fermentation organisms in food fermentations but their metabolic pathways for conversion of (poly)-phenolic compounds have been elucidated only in the past two decades. The first step of conversion is the hydrolysis of esters or glycosides of phenolic compounds. This study aimed to evaluate the ability of Lactobacillus crispatus FUA3540, Companilactobacillus paralimentarius FUA3121, Lacticaseibacillus paracasei FUA3413, Lactiplantibacillus plantarum TMW1.460, Levilactobacillus hammesii LP38T, Furfurilactobacillus rossiae FUA3124, and Ff. milii FUA3430T and Fructilactobacillus sanfranciscensis DSM20451T to hydrolyse glycosides of secondary plant metabolites.
The genomes of these strains encoded for 5, 20, 8, 10, 2, 1, 2 and 0 β-glucosidases or phospho‑β‑glucosidases, respectively. L. crispatus, Cp. paralimentarius, Lc. paracasei and Lp. plantarum but not Lv. hammesii, Ff. rossiae or Ff. milii hydrolysed cellobiose. The hydrolysis of amygladin, esculin, and salicin matched the hydrolysis of cellobiose. With exception of Fl. sanfranciscensis, all strains hydrolysed spiraeoside and genistin. Lp. plantarum and Cp. paralimentarius additionally hydrolysed isoquercetin.
Prof. Gänzle's data support the previous observation that many of the glycosyl hydrolases in lactobacilli are specific for glycosylated secondary plant metabolites rather than di- and oligosaccharides. Increased knowledge on their substrate specificity will facilitate the selection of fermentation organisms to secondary plant metabolites with desirable or undesirable biological activities in food fermentations.
Join us in Polyphenols Applications 2023 to learn more about Prof. Gänzle's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Sustainable sources for Polyphenols Recovery and their Application in Healthy Food
Dr. Isabella D’Antuono from the Institute of Sciences of Food Production National Research Council (ISPA – CNR), Italy, will join the Polyphenols Applications 2023 Congress and present the talk entitled "Sustainable Sources for Polyphenols Recovery and their Application in Healthy Food".
Functional foods are an innovative response of food industries to consumer expectations. Their sector includes foods naturally rich in bioactive compounds or enriched in bio-ingredients stemming from unexploited sources, as a virtuous application of the circular economy concept.
Join us in Polyphenols Applications 2023 to learn more about Dr. D’Antuono's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Polyphenols in Depression & Neurodegenerative Diseases
Prof. Giulio Maria Pasinetti from 
Icahn School of Medicine at Mount Sinai, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Polyphenols in Depression & Neurodegenerative Diseases".
Join us in Polyphenols Applications 2023 to learn more about Dr. Pasinetti's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Book your hotel and benefit from the best rate
Corinthia Palace Malta will be the conference hotel of Polyphenols Applications 2023 on September 28-29.
Hotel Booking for Attendees: Special Rate
This year's attendees will be able to benefit from a discount on their booking at the conference hotel.
Available rooms include: Deluxe double, executive double, and executive suites for sole use.
The room rate includes full breakfast and VAT. Please note that the offer is valid until July 31, with a limited number of rooms.
Book you room with a preferential rate now.
If you need more than 2 rooms, please contact the hotel directly via email, mentioning that you will attend Polyphenols Applications 2023.
More about the hotel and activities in Malta.
Registration Details
Register early and book your spot to to learn about this year's new scientific outlook on Polyphenols Applications in lovely Malta.
Polyphenols Applications Congress
September 28-29, 2023 - Malta
Plant-Derived Polyphenols as Senolytic Agents
Cellular senescence is a basic aging process that drives several age-related degenerative conditions. Compounds that selectively eliminate senescent cells, commonly called “senolytics”, have the potential to improve multiple degenerative conditions by targeting this key age-promoting process.
Several polyphenols have been shown to have senolytic activity, including the hops-derived chalconoid xanthohumol, presenting a new pathway by which these molecules might improve degenerative disease.
Dr. Christopher Wiley from Tufts University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Plant-Derived Polyphenols as Senolytic Agents".
About Dr. Wiley
Dr. Wiley is a Scientist II at the Jean Mayer USDA Human Nutrition Research Center on Aging and an Assistant Professor in the School of Medicine at Tufts University. His laboratory studies the interactions between metabolism and cell fate decisions such as cellular senescence and cell death, primarily in the context of aging and degenerative disease.
Join us in Polyphenols Applications 2023 to learn more about Dr. Wiley's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Cranberry Polyphenols Inhibit Esophageal Cancer Through Reshapeing the Microbiome-Metabolome Axis
Dr. Laura Kresty from the University of Michigan, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Cranberry Polyphenols Inhibit Esophageal Cancer Through Reshapeing the Microbiome-Metabolome Axis".
Join us in Polyphenols Applications 2023 to learn more about Dr. Kresty's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Catechol-based Nanostructures in Medicine
Prof. Daniel Ruiz Molina from Universitat Autònoma de Barcelona, Spain, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Catechol-based Nanostructures in Medicine".
The experience and background of the team brings an important asset in the synthesis of “sticky” catechol based coatings and nanoparticles with bioadhesion properties in humid conditions. This involves: I) Synthesis of nanoparticles/nanocapsules intended for chemo-/phototherapy with encapsulated drugs and study of the controlled release, II) novel coating for biofunctionalization, colloidal stabilization in physiological media experimental conditions and III) a patch to damaged tissue that allow for the growth of healthy cells in a very effective way that will naturally induce a faster regeneration of the tissue.
Join us in Polyphenols Applications 2023 to learn more about Prof. Ruiz's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Multi-omics Approach Reveal Biomarkers of Metabolic Resilience in Healthy Participants Supplemented With Grape Polyphenols
Dr. Diana Roopchand from Rutgers University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Multi-omics Approach Reveal Biomarkers of Metabolic Resilience in Healthy Participants Supplemented With Grape Polyphenols".
Grape polyphenols (GPs) extracted from grape pomace are rich in proanthocyanidins (PACs) compounds which are not bioavailable; however, evidence suggests their health benefits are likely mediated via the gut microbiota and/or bacterial metabolites.
Serum, fecal, and/or urine samples were collected before and after 2, 4, and 10 days of GP supplementation followed by shotgun metagenomic sequencing, mass spectrometry-based metaproteomics, and/or targeted metabolomics. Notable GP-induced bile acid changes appeared to be gender-specific and correlational analyses uncovered novel associations between gut microbes and metabolites associated with metabolic resilience.
Join us in Polyphenols Applications 2023 to learn more about Prof. Roopchand's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Phenolic Compounds, Bioaccessibility and Characterization in Foods
Prof. Trust Beta from the University of Manitoba, Canada, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Phenolic Compounds: Their Characterization and Bioaccessibility in Cereal Foods".
Globally, cereal grains serve as a source of affordable, staple foods. They comprise minor phytochemicals which may function to reduce oxidative stress. Grain phenolics are among compounds of interest as they have been shown to exhibit antioxidant and anti-inflammatory functions. Their characterization and bioaccessibility in cereal grains will be discussed during this presentation.
Join us in Polyphenols Applications 2023 to learn more about Prof. Beta's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Biological Activities of Phenol-Amino Acid Adducts: Towards enhancing Food Quality
Dr. Marianne Nissen Lund from the University of Copenhagen, Denmark will join the Polyphenols Applications 2023 congress and give a major presentation entitled "Biological Activities of Phenol-Amino Acid Adducts: Towards Enhancing Food Quality".
When polyphenols are oxidized to quinones they react with proteins in foods, with cysteine residues on proteins being kinetically preferred targets. Caffeic acid-cysteine and chlorogenic acid-cysteine adducts have been detected in commercial coffee-milk drinks. Thus, these adducts were synthesized and their anti-inflammatory activity was tested in lipopolysaccharide-treated RAW 264.7 cells in comparison to their parent phenolic acids.
Dr. Lund's results demonstrate that the addition of a cysteine moiety to phenolic acids enhances their anti-inflammatory responses in macrophages.
Join us in Polyphenols Applications 2023 to learn more about Dr. Lund's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
The Latest Advances in the Biotechnological Production of Phenolic Compounds
Dr. Matheos Koffas from the Rensselaer Polytechnic Institute, School of Engineering, USA will join the Polyphenols Applications 2023 congress and will give a major presentation entitled "The Latest Advances in the Biotechnological Production of Phenolic Compounds".
Join us in Polyphenols Applications 2023 to learn more about Dr. Koffas's talk during the session "Polyphenols & Food Research: The Most Recent Developments".
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Dietary Polyphenols Inhibit Production of Trimethylamine, a Gut Microbial Metabolite Associated With Aging and Atherosclerosis
Prof. Andrew P. Neilson, North Carolina State University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Dietary Polyphenols Inhibit Production of Trimethylamine, a Gut Microbial Metabolite Associated With Aging and Atherosclerosis".
Cardiovascular disease causes ~32% of deaths worldwide. Elevated blood trimethylamine N-oxide (TMAO) levels were identified in 2011 as a risk factor for atherosclerosis development. TMAO is formed through a microbial-host axis involving oxidation of dietary choline to trimethylamine (TMA) by gut bacteria containing the cutC/D gene cluster. TMA is absorbed into circulation and oxidized to TMAO by hepatic flavin-containing monooxygenase 3. TMAO promotes cardiovascular disease through multiple mechanisms.
There is no FDA-approved drug to control TMAO levels, underscoring the need for complementary strategies to manage TMAO production. Dietary phytochemicals such as phenolics represent one potential solution. Phenolics have shown promise for altering the structure and function of the gut microbiome and providing cardioprotective benefits. Interest is emerging in TMAO-lowering activities of phenolics. There is a need to rapidly screen large numbers of phenolics and other dietary bioactives (compounds foods, extracts, etc.) to identify potential lead compounds for subsequent preclinical animal studies.
Prof. Neilson and his team developed and validated a high-throughput, low-volume 96-well ex vivo-in vitro anaerobic fecal fermentation method using human fecal samples and choline-d9 substrate and measuring the resultant TMA-d9. They paired this with a rapid, high-throughput analytical platform by employing an automated liquid handling robot for sample prep and a fast, sensitive 96-well LC-MS/MS method. Model validation experiments confirmed that choline-d9 utilization and TMA-d9 production occur with ~1:1 stoichiometry, with no background interference, and are dependent upon the presence of gut bacteria. Using this model, they identified chlorogenic acid, epicatechin and foods rich in these phenolics (coffee, cocoa and artichoke) as potent TMA production inhibitors.
In vitro and animal studies will elucidate the mechanisms of inhibition and demonstrate efficacy in vivo. TMA/TMAO-lowering activities may be a previously unknown mechanism by which dietary phenolics exert their cardioprotective effects.
Join us in Polyphenols Applications 2023 to learn more about Prof. Neilson's talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Berries Polyphenols & Vascular Function: Current Evidence and Mechanisms of Action
Prof. Cristian Del Bo', from the Università degli Studi di Milano, Italy, will join the 16th World Congress on Polyphenols Applications 2023 and give a talk entitled "Berries Polyphenols & Vascular Function: Current Evidence and Mechanisms of Action".
Join us in Polyphenols Applications 2023 to learn more about Prof. Del Bo''s talk.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Hormetic response to B-type procyanidin ingestion may involve stress-related neuromodulation via the gut–brain axis: Preclinical and clinical observations
Dr. Naomi Okasabe, from Shibaura Institute of Technology, Japan will join the Polyphenols Applications 2023 congress which will be held in Malta, on September 28-29, 2023, and present the "Hormetic response to B-type procyanidin ingestion may involve stress-related neuromodulation via the gut–brain axis: Preclinical and clinical observations".
B-type procyanidins, a series of catechin oligomers, reduce cardiovascular disease risk and impact central nervous system (CNS) function. Comprehensive analyses of previous reports indicate an optimal mid-range dose for the hemodynamic effects of B-type procyanidins, with null responses at lower or higher doses, suggesting hormesis. Dr. Okasabe previously confirmed the hormesis of hemodynamic responses to B-type procyanidins in animal studies, in addition, our work has linked these effects to the CNS. In this presentation, we evaluate the hormetic response elicited by B-type procyanidins, recontextualizing the results of intervention trials. In addition, Dr. Okasabe will discuss the possibility that this hormetic response to B-type procyanidins arises via CNS neurotransmitter receptors.
Join us in Polyphenols Applications 2023 and benefit from the experience of professional researchers like Dr. Okasabe.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Marine Polyphenols - Characterization and Applications
Prof. Monica Jordheim, University of Bergen, Norway will join the Polyphenols Applications 2023 congress to present a talk on "Marine Polyphenols - Characterization and Applications".
The world's population is projected to reach 9 billion by 2050, and utilization of bioresources will be increasingly important for food, feed, and health applications. Seaweeds, or macroalgae, are a sustainable biomass and they play an increasing role in aquaculture and marine bioresource development. However, they are still identified as an underexplored resource – and marine polyphenols are less explored compared to terrestrial polyphenols.
Prof. Jordheim will, in this presentation, discuss the importance of quantification and identification at the molecular level in order to uncover and understand the algae's potential in industrial applications. The experienced challenges in working with seaweed biomass compared to terrestrial biomass will be addressed, and results from industrial projects will be presented.
About Prof. Jordheim
Prof. Jordheim has over twenty years of experience in quantification and identification of polyphenols, including full molecular elucidation using NMR and HR-LC-MS. She has co-authored several book chapters on the chemistry of anthocyanins and identified more than twenty new structures from nature. The recent years Jordheim has focused on polyphenols from seagrasses and seaweeds including industrial collaborations and innovation projects. Prof. Jordheim is also the head of education at the Department of Chemistry at University of Bergen, Norway, and the leader of the larger research group Bioresources and Pharmaceutical Chemistry (BPC).
Join us in Polyphenols Applications 2023 and benefit from the experience of professional researchers like Prof. Jordheim.
Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com
Share Your Abstract During Polyphenols Applications 2023
The abstract submission process for Polyphenols World Congress 2023 is now open.
Get your abstracts ready and share them with the scientific committee to communicate your work with worldwide scientists, industrials, and polyphenols enthusiasts.
Abstracts related to the following topics can be submitted. Submit an abstract.
Feel free to contact us for any questions.
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Polyphenols Applications Conference
September 27-29, 2023
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