News Alert

Cranberry Polyphenols Inhibit Esophageal Cancer Through Reshapeing the Microbiome-Metabolome Axis

Dr. Laura Kresty from the University of Michigan, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Cranberry Polyphenols Inhibit Esophageal Cancer Through Reshapeing the Microbiome-Metabolome Axis".

Join us in Polyphenols Applications 2023 to learn more about Dr. Kresty's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Catechol-based Nanostructures in Medicine

Prof. Daniel Ruiz Molina from Universitat Autònoma de Barcelona, Spain, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Catechol-based Nanostructures in Medicine".

The experience and background of the team brings an important asset in the synthesis of “sticky” catechol based coatings and nanoparticles with bioadhesion properties in humid conditions. This involves: I)  Synthesis of nanoparticles/nanocapsules intended for chemo-/phototherapy with encapsulated drugs and study of the controlled release, II) novel coating for biofunctionalization, colloidal stabilization in physiological media experimental conditions and III) a patch to damaged tissue that allow for the growth of healthy cells in a very effective way that will naturally induce a faster regeneration of the tissue.

Join us in Polyphenols Applications 2023 to learn more about Prof. Ruiz's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Multi-omics Approach Reveal Biomarkers of Metabolic Resilience in Healthy Participants Supplemented With Grape Polyphenols

Dr. Diana Roopchand from Rutgers University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Multi-omics Approach Reveal Biomarkers of Metabolic Resilience in Healthy Participants Supplemented With Grape Polyphenols".

Grape polyphenols (GPs) extracted from grape pomace are rich in proanthocyanidins (PACs) compounds which are not bioavailable; however, evidence suggests their health benefits are likely mediated via the gut microbiota and/or bacterial metabolites.

Serum, fecal, and/or urine samples were collected before and after 2, 4, and 10 days of GP supplementation followed by shotgun metagenomic sequencing, mass spectrometry-based metaproteomics, and/or targeted metabolomics. Notable GP-induced bile acid changes appeared to be gender-specific and correlational analyses uncovered novel associations between gut microbes and metabolites associated with metabolic resilience.

Join us in Polyphenols Applications 2023 to learn more about Prof. Roopchand's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Phenolic Compounds, Bioaccessibility and Characterization in Foods

Prof. Trust Beta from the University of Manitoba, Canada, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Phenolic Compounds: Their Characterization and Bioaccessibility in Cereal Foods".

Globally, cereal grains serve as a source of affordable, staple foods. They comprise minor phytochemicals which may function to reduce oxidative stress. Grain phenolics are among compounds of interest as they have been shown to exhibit antioxidant and anti-inflammatory functions. Their characterization and bioaccessibility in cereal grains will be discussed during this presentation.

Join us in Polyphenols Applications 2023 to learn more about Prof. Beta's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Biological Activities of Phenol-Amino Acid Adducts: Towards enhancing Food Quality

Dr. Marianne Nissen Lund from the University of Copenhagen, Denmark will join the Polyphenols Applications 2023 congress and give a major presentation entitled "Biological Activities of Phenol-Amino Acid Adducts: Towards Enhancing Food Quality".

When polyphenols are oxidized to quinones they react with proteins in foods, with cysteine residues on proteins being kinetically preferred targets. Caffeic acid-cysteine and chlorogenic acid-cysteine adducts have been detected in commercial coffee-milk drinks. Thus, these adducts were synthesized and their anti-inflammatory activity was tested in lipopolysaccharide-treated RAW 264.7 cells in comparison to their parent phenolic acids.

Dr. Lund's results demonstrate that the addition of a cysteine moiety to phenolic acids enhances their anti-inflammatory responses in macrophages.

Join us in Polyphenols Applications 2023 to learn more about Dr. Lund's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

The Latest Advances in the Biotechnological Production of Phenolic Compounds

Dr. Matheos Koffas from the Rensselaer Polytechnic Institute, School of Engineering, USA will join the Polyphenols Applications 2023 congress and will give a major presentation entitled "The Latest Advances in the Biotechnological Production of Phenolic Compounds".

Join us in Polyphenols Applications 2023 to learn more about Dr. Koffas's talk during the session "Polyphenols & Food Research: The Most Recent Developments". 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Dietary Polyphenols Inhibit Production of Trimethylamine, a Gut Microbial Metabolite Associated With Aging and Atherosclerosis

Prof. Andrew P. Neilson, North Carolina State University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Dietary Polyphenols Inhibit Production of Trimethylamine, a Gut Microbial Metabolite Associated With Aging and Atherosclerosis".

Cardiovascular disease causes ~32% of deaths worldwide. Elevated blood trimethylamine N-oxide (TMAO) levels were identified in 2011 as a risk factor for atherosclerosis development. TMAO is formed through a microbial-host axis involving oxidation of dietary choline to trimethylamine (TMA) by gut bacteria containing the cutC/D gene cluster. TMA is absorbed into circulation and oxidized to TMAO by hepatic flavin-containing monooxygenase 3. TMAO promotes cardiovascular disease through multiple mechanisms.

There is no FDA-approved drug to control TMAO levels, underscoring the need for complementary strategies to manage TMAO production. Dietary phytochemicals such as phenolics represent one potential solution. Phenolics have shown promise for altering the structure and function of the gut microbiome and providing cardioprotective benefits. Interest is emerging in TMAO-lowering activities of phenolics. There is a need to rapidly screen large numbers of phenolics and other dietary bioactives (compounds foods, extracts, etc.) to identify potential lead compounds for subsequent preclinical animal studies.

Prof. Neilson and his team developed and validated a high-throughput, low-volume 96-well ex vivo-in vitro anaerobic fecal fermentation method using human fecal samples and choline-d₉ substrate and measuring the resultant TMA-d₉. They paired this with a rapid, high-throughput analytical platform by employing an automated liquid handling robot for sample prep and a fast, sensitive 96-well LC-MS/MS method. Model validation experiments confirmed that choline-d₉ utilization and TMA-d₉ production occur with ~1:1 stoichiometry, with no background interference, and are dependent upon the presence of gut bacteria. Using this model, they identified chlorogenic acid, epicatechin and foods rich in these phenolics (coffee, cocoa and artichoke) as potent TMA production inhibitors.

In vitro and animal studies will elucidate the mechanisms of inhibition and demonstrate efficacy in vivo. TMA/TMAO-lowering activities may be a previously unknown mechanism by which dietary phenolics exert their cardioprotective effects.

Join us in Polyphenols Applications 2023 to learn more about Prof. Neilson's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Berries Polyphenols & Vascular Function: Current Evidence and Mechanisms of Action

Prof. Cristian Del Bo', from the Università degli Studi di Milano, Italy, will join the 16th World Congress on Polyphenols Applications 2023 and give a talk entitled "Berries Polyphenols & Vascular Function: Current Evidence and Mechanisms of Action".

Join us in Polyphenols Applications 2023 to learn more about Prof. Del Bo''s talk.

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Hormetic response to B-type procyanidin ingestion may involve stress-related neuromodulation via the gut–brain axis: Preclinical and clinical observations

Dr. Naomi Okasabe, from Shibaura Institute of Technology, Japan will join the Polyphenols Applications 2023 congress which will be held in Malta, on September 28-29, 2023, and present the  "Hormetic response to B-type procyanidin ingestion may involve stress-related neuromodulation via the gut–brain axis: Preclinical and clinical observations".

B-type procyanidins, a series of catechin oligomers, reduce cardiovascular disease risk and impact central nervous system (CNS) function. Comprehensive analyses of previous reports indicate an optimal mid-range dose for the hemodynamic effects of B-type procyanidins, with null responses at lower or higher doses, suggesting hormesis. Dr. Okasabe previously confirmed the hormesis of hemodynamic responses to B-type procyanidins in animal studies, in addition, our work has linked these effects to the CNS. In this presentation, we evaluate the hormetic response elicited by B-type procyanidins, recontextualizing the results of intervention trials. In addition, Dr. Okasabe will discuss the possibility that this hormetic response to B-type procyanidins arises via CNS neurotransmitter receptors.

Join us in Polyphenols Applications 2023 and benefit from the experience of professional researchers like Dr. Okasabe.

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Marine Polyphenols - Characterization and Applications

Prof. Monica Jordheim, University of Bergen, Norway will join the Polyphenols Applications 2023 congress to present a talk on "Marine Polyphenols - Characterization and Applications".

The world's population is projected to reach 9 billion by 2050, and utilization of bioresources will be increasingly important for food, feed, and health applications. Seaweeds, or macroalgae, are a sustainable biomass and they play an increasing role in aquaculture and marine bioresource development. However, they are still identified as an underexplored resource – and marine polyphenols are less explored compared to terrestrial polyphenols.

Prof. Jordheim will, in this presentation, discuss the importance of quantification and identification at the molecular level in order to uncover and understand the algae's potential in industrial applications. The experienced challenges in working with seaweed biomass compared to terrestrial biomass will be addressed, and results from industrial projects will be presented.

About Prof. Jordheim

Prof. Jordheim has over twenty years of experience in quantification and identification of polyphenols, including full molecular elucidation using NMR and HR-LC-MS. She has co-authored several book chapters on the chemistry of anthocyanins and identified more than twenty new structures from nature. The recent years Jordheim has focused on polyphenols from seagrasses and seaweeds including industrial collaborations and innovation projects. Prof. Jordheim is also the head of education at the Department of Chemistry at University of Bergen, Norway, and the leader of the larger research group Bioresources and Pharmaceutical Chemistry (BPC).

Join us in Polyphenols Applications 2023 and benefit from the experience of professional researchers like Prof. Jordheim.

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Share Your Abstract During Polyphenols Applications 2023

The abstract submission process for Polyphenols World Congress 2023 is now open.

Get your abstracts ready and share them with the scientific committee to communicate your work with worldwide scientists, industrials, and polyphenols enthusiasts.

Abstracts related to the following topics can be submitted. Submit an abstract.

Feel free to contact us for any questions.

Media Contact:
Polyphenols Applications Team
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Polyphenols Applications Conference
September 27-29, 2023
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Photographed Souvenirs of Polyphenols Applications 2022

Thank you for sharing us memories of Polyphenols Applications 2022. You can now view this year's photographed moments.

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Prof. Juan Carlos Espin was discerned the Scientific Award 2022

The scientific committee of Polyphenols Applications 2022 awarded Prof. Juan Carlos Espín, Spanish National Research Council, Spain, the Best Scientific Award of the year during the 15th #PolyphenolsWorldCongress. This award was given for his brilliant presentation about the past, present, and future research on polyphenols "Polyphenols 2022: Where We Are Now and What’s Next". Prof. Espín gave an exhaustive presentation about the current research on polyphenols, as well as clear vision on the future of polyphenol research, raising many questions that can be useful in furture research: Can we personalize polyphenols health effects? Can we create personalized and specific probiotics aiming to reduce the variability of polyphenols metabolism? How can we take into consideration the interactions between polyphenols and medication? What are the methods to improve polyphenols systemic delivery? Prof. Espín stated: “I am very grateful to the Scientific Committee of the Polyphenols Applications Congress 2022 for this recognition. The Best Scientific Contribution Award is undoubtedly a great honor. I am proud to have spread the importance of polyphenol research through this renowned forum.” The scientific committee congratulates Prof. Juan Carlos Espín for his achievement and is looking forward to learning more about his studies.

Extract of Prof. Juan Carlos Espín's presentation

You can watch his interesting presentation if you missed it by ordering the conference's replay. Know more about it.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
#PolyphenolsWorldCongress
www.polyphenols-site.com

The committee awarded 3 Poster Presentations during Polyphenols Applications 2022

During the 15th #PolyphenolsWorldCongress which was held on September 28-30 2022 in Valenci, the committee chose 3 Best Poster Presentations which were distinguished by their quality of research and presentation.

Klara Supikova, Palacky University Olomouc, Czech Republic was discerened an award for her poster entitled "Sulfated Phenolic Acids are Common Plant Metabolites".

This study describes mainly novel sulfated derivatives of phenolic acids identified in plants. Only some of these compounds were detected before, nevertheless, only in marine species (seagrasses and algae).

Klara stated: "In the future, I would like to focus on the identification of other unknown potentially sulfated compounds present in nature, as we already know, the plant "sulfatome" is quite rich in some cases. A challenging task for me and my colleagues will be the discovery of sulfotransferases responsible for the biosynthesis. Moreover, the definition of the physiological functions of sulfated phenolics in plants remains also unclear, thus, I would like to direct my research activities to answer these questions."

Another poster award was given to Sandra Mariño-Cortegoso, University of Santiago de Compostela, Spain, for her contribution "Recovery of Bioactive Compounds From Lime and Lemon By-Products Through Sustainable Methodologies". 

When asked, Sandra affirmed: “This work is a part of the research project VALICET focuses on the valorization of fruit by-products using green extraction technologies for future approaches in the application of fruit by-products as food ingredients and additives through the recovery of added-value compounds. Future work will be done on the encapsulation of the bioactive compounds to develop ingredients, edible and active packaging and coatings to extend food shelf-life."

Katia Ruel, ADKALIS - Groupe BERKEM, France, was also discerned an award for her poster contribution "Plant Polyphenolic Extract From Berkem Biosolutions® for Antimicrobial Protection of Cosmetic Products".

Katia stated: "In keeping with my interest in the activity of polyphenols in the domains of cosmetics and of protection of wood  and grains against biological predators, my research in collaboration with Groupe Berkem R&D laboratories will deepen understanding of the mechanisms underlying the action of these natural plant polyphenolics extracts.”

The scientific committee of Polyphenols Applications congratulates the winners once again. We will be looking forward to learning about their progress during the next edition. 

If you missed on the posters, you can access all absracts by ordering the abstracts book.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
#PolyphenolsWorldCongress
www.polyphenols-site.com

3 Short Oral Presentation Awards were given in 2022

Many Short Oral Presentations were submitted during the 15th #PolyphenolsWorldCongress, held on September 28-30 2022 in Valencia, Spain. The committee voted for the best 3 of these short oral presentations.

Paul Besrukow, Geisenheim University, Germany, was awarded the first prize of the Best Short Oral Presentation 2022 for his studies on "Grape Cane Stilbenoids as Biopesticides in Organic Viticulture".

Mr. Besrukow is working on the analysis, valorization and application of polyphenols extracted from agricultural by-products. In scope of the joint project VITIFIT, which focuses on the reduction of copper usage in organic viticulture, he investigates the antifungal efficacy of differently formulated stilbenoid-rich grape cane extracts on Plasmopara viticola, causal agent of grapevine downy mildew. 

Cornelia Schmutz, University of Vienna, Austria, received the second best short oral presentation award for her contribution on "Anthocyanin-Rich Berry Extracts and Chemotherapy: A Critical Combination". 

Irinotecan, as pro-drug of SN-38, is a frequently chosen chemotherapy option for colorectal cancer. Bioactive plant ingredients, so-called anthocyanins, are promising candidates to possibly alleviate adverse effects induced by the topoisomerase (TOPO) poison SN-38. Hence, the FWF funded project is centered on potential protective or adverse effects of anthocyanin-rich berry extracts during chemotherapy. In vitro experiments already showed reduced DNA/TOPO I intermediates, in both tumorigenic and non-tumorigenic colon cells.

Future work will focus on the relevance of the observed effects inin vivomodels of tumor-bearing animals.

The last Best Short Oral award was discerned to Learnmore Kambizi, Cape Peninsula University of Technology, South Africa, for his short oral contribution "Pigmented Potatoes: A Potential Panacea for Food and Nutrition Security and Health?"

Prof. Kambizi is a full professor of Botany at the Cape Peninsula University of Technology, South Africa. His main interests are Ethnobotany, Phytomedicine, Botany, Medicinal Plants, Sustainable utilization and conservation, Food and Nutrition Security.

His interests in working with Traditional Medical Practitioners are a major part of his work. Prof Kambizi was appointed the first Director of African Centre for Herbal Research based in Nigeria, a position he holds to date. Although Prof Kambizi is well vested in medicinal plants, he has interests in food and nutrition security with the vision 2030 UN Sustainable Development Goals in mind. These interests have led him to start work on indigenous underutilised pigmented potato cultivars. This is because of their immense potential in ameliorating food and nutrition insecurity as shown in this review that he put together. So far, he has worked on the role of root zone temperature on physiological growth and phytochemical constituents as well as biological activity, in Salad Blue, Pink Fir Apple and Highland Burgundy Red pigmented potato cultivars, among other studies. Although phytochemical constituent results look promising, the biological activities are not conclusive. Therefore, further studies are required to elucidate these activities.

Prof Kambizi stated: "Going forwards, I am interested in studying more cultivars from different parts of the world to see their responses to different biotic and abiotic stresses especially in South Africa where I am based, isolation of the main phenolic compounds, elucidation of their activities, and bioavailability of these compounds especially after processing. Bioavailability studies post processing will potentially open insights into the quality and quantity of the compounds that would be useful in human physiology and therefore link these compounds to the health benefits of these potatoes. I am actively looking for funding and collaborators to pursue these studies and I am open to any such around the globe."

If you wish to catch up on the presentations you missed, including these winning contributions, you can order the conference's replay or the abstracts book. Know more about it.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
#PolyphenolsWorldCongress
www.polyphenols-site.com

Polyphenols Applications 2022 World Congress Highlights

The 15th World Congress on Polyphenols Applications will take place from the 28th to the 30th of September at ADEIT 'Fundación Universitat', Valencia, Spain, & Online after 2 years.

A workshop during Polyphenols Applications 2022 will be dedicated to Cannabis & Cannabinoids under the presidency of by Professor Jan Frederik Stevens, Oregon State University, USA.

Professor Andreas Schieber, President of Polyphenols Applications, University of Bonn, Germany, stated: "Polyphenols Applications 2022 will shed light on the most recent discoveries and blooming topics":

Microbiota, metabolites, adipose tissue, nervous system, senolytic activity, ageing, endothelial function, radioprotection, oxidative stress, ferroptosis, cancer, atherosclerosis, extracellular vesicles, cannabinoids, cannabinoid receptors, anticancer activity, antiviral activity, anti-dyslipidemic effect, ocular delivery, cosmetic application, polyphenols recovery, extraction, valorization, fermentation, wine polyphenols, sensory aspects, inter-individual variability...

More than 170 international participants will be attending in-person and online, and more than 131 communications will be presented during the conference.

Among important companies that will be joining: Silvateam, Bioquochem, ElderCraft, IPRONA, Canurta Inc., Ajinomoto OmniChem NV, Layn USA, and many others.

Abstract Submission

• Short Oral Presentation submission deadline: September 5
• Poster Presentation submission deadline: September 9

More details on abstract submission. 

Access to Cannabis & Cannabinoids Workshop

More information about the workshop sessions. 

Registration for workshop or workshop & congress. 

Polyphenols Applications 2022 Congress
September 28-30, 2022
ADEIT, Valencia, Spain & Online
www.polyphenols-site.com

Keynote Introduction: Polyphenols 2022: Where We Are Now and What’s Next

Prof. Juan Carlos Espín, Spanish National Research Council, Spain, introduced this year's meeting with a keynote introduction on “Polyphenols Application 2022: Where We Are Now and What’s Next”.

 Prof. Espín addressed the past, present, and future research on this topic. He also made an overview on the barriers, metabolites and new key players in this science, with an emphasis on microbiota and the challenge of modulating the gut microbiota in metabolic syndrome patients.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Polyphenol-Protein Interactions - Still Many Challenges to Cope With...

Dr. Sascha Rohn, Technische Universität Berlin, Germany, will join us this year to present a talk entitled “Polyphenol-Protein Interactions - Still Many Challenges to Cope With...”

More and more researchers are dealing with the characterization of interactions of polyphenols with other food ingredients. In this ocasion, proteins are interesting, as they can interact (non-covalently), but als form (covalent) reactions products, highly depending on the interaction/reaction conditions, as well as on the initial properties of the polyphenols and the proteins. Cosequently, interaction and reaction products might affect technofunctional and physiological properties (of the corresponding foods) as well. One can even think of covalent polymeric reaction products that affect color, solubility and lead to unrevealed nutritional consequences. Overall, this is a bunch of complex challenges that need to be considered.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Rohn.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Beneficial Health Effects of Polyphenol-Rich Fruit Juice in Humans

Prof. Elke Richling, University of Kaiserslautern, Germany, will join Polyphenols Applications 2022 to present recent advances on the "Beneficial Health Effects of Polyphenol-Rich Fruit Juice in Humans".

In vitro and in vivo studies provide evidence that polyphenol-rich fruit juices and their extracts can influence lipid metabolism as well as improve DNA integrity.

To substantiate preliminary findings, Prof. Richling and her team performed a placebo-controlled intervention study with 36 male healthy subjects (age 20–40 years, body mass index 19–25 kg/m²). After one week washout period, the volunteers consumed 750 mL/day of a polyphenol-rich fruit juice (containing chokeberry, cranberry, and pomegranate) or placebo drink for eight weeks. Blood sampling was performed after the washout period as well as after four and eight weeks of intervention and used to analyse biomarkers of the lipid metabolism like blood platelet cyclic adenosine monophosphate phosphodiesterase (cAMP-PDE) activity. In addition, effects on DNA strand breaks and on body weight/composition were monitored.

The results showed a significant inhibition of cAMP-PDE activity (p<0.01) and decrease in DNA strand breaks (p<0.05) during juice consumption. Consuming juice, an increased fat-free mass (p<0.05) was found after four weeks, whereas a significant (p<0.05) elevation in body weight was observed in control group.

Taken together their results indicate health beneficial effects associated with polyphenol-rich fruit juice consumption.

Join us in Polyphenols Applications 2022 to know more about these findings and many more topics.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Gut Microbial Metabolism of Dietary Polyphenols in Health and Disease

Dr. Jan Claesen, from Cleveland Clinic, USA, will join us this year to present a talk entitled “Gut Microbial Metabolism of Dietary Polyphenols in Health and Disease” in a session dedicated to “Polyphenols & Microbiota – Recent Advances & Perspectives”.

Flavonoids are consumed in a largely glycosylated form, rendering them poorly available for small intestinal absorption and subsequent systemic distribution. Upon reaching the colon, select commensal gut bacteria can catabolize these flavonoid substrates into smaller monophenolic acids.

In his talk, Dr. Claesen will discuss the contribution of microbial catabolism to the beneficial effects of dietary flavonoids in health and in disease. 

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Claesen.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com