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Phenolic compounds in Food waste valorization: figures and perspectives

Richard Maroun Bonn Polyphneols 2018

During the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018, Prof. Richard Maroun from Saint-Joseph University of Beirut, Beirut, Lebanon will give presentation about "Phenolic compounds in Food waste valorization: figures and perspectives".

According to Prof. Richard Maroun: "Food waste valorization practices have gained much attention lately as a means of sustainable management. These materials constitute an underexploited source for the recovery of natural compounds. The value of food byproducts is associated with their content in dietary fibers and several bioactive molecules which can be capitalized in the food, pharmaceutical, cosmetic and nutraceutical industries. One of the main molecules extracted and purified are polyphenols. Our work aims to purify these natural antioxidant molecules through innovative technologies in order to reintegrate them as valuable additives in several industrial applications".

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Development of microbial production platforms for plant polyphenols

Mattheos Koffas Polyphenols 2018Prof. Mattheos Koffas from Rensselaer Polytechnic Institute, USA will talk about the "Development of microbial production platforms for plant polyphenols" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

According to Prof. Mattheos Koffas: "In the past 15 years, we have applied metabolic engineering towards the development of robust and efficient microbial production platforms for the production of plant polyphenols. We will present a number of examples where single hosts have been optimized for the production of various flavonoids starting from intermediates such as phenylpropanoic acids and flavanones, using stoichiometric-based modeling and metabolic pathway balancing. We will then present examples of using co-cultures involving such individual strains for the de novo production optimization of various flavonoids from glucose."

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Anthocyanins - Color enhancing strategies

prof reinhold-polyphenolsProf. Reinhold Carle from the University of Hoheneim will present his work about "Anthocyanins – Color enhancing strategies" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

Apart from taste, aroma and texture, color is the most important attribute determining consumer acceptance. Many foods are colored to compensate for color losses due to harsh processing conditions and long-term storage. Furthermore, unappealing visual perception of colorless food is meliorated by the addition of artificial and natural pigments. Owing to their low cost, high stability and superior tinctorial strength, usage of synthetic and animal-based dyes has prevailed over a long period.

Nowadays, due to growing health consciousness, religious rejection, legal restrictions, and the trend toward vegetarian lifestyle, these are progressively replaced by plant pigments. However, the latter are suffering from a limited color palette, poor heat and light stability, sensitivity against high pH, complexing agents, and oxidation. Most frequently, fruit and vegetable concentrates containing anthocyanins and refined preparations thereof are a natural alternative, when water-soluble pigments producing red to bluish tonalities are demanded.

In his presentation, Prof. Carle will highlight the role and importance of color to enhance strategies.

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Activity guided fractionation of red fruit juices to identify α amylase and α glucosidase inhibitors in vitro

Kirsten Berger Bonn Polyphenols 2018 v1

Kirsten Berger from University of Kaiserslautern, Kaiserslautern, Germany will talk about "Activity guided fractionation of red fruit juices to identify α amylase and α glucosidase inhibitors in vitro" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

The inhibitory potential of polyphenols against enzymes of the carbohydrate metabolism, such as α‑amylase and α‑glucosidase has been described in some studies. A rich source of polyphenols, especially anthocyanins are red fruits. Our studies examined the in vitro inhibitory activity of extracts and fractions prepared from juices, concentrates, and purees against α‑amylase and α‑glucosidase.


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Non-estrogenic xanthohumol derivatives improve cognitive function in diet-induced obese mice

Jan Frederik Stevens - vienna Polyphenols 2018Prof. Fred Stevens from Oregon State University, Corvallis, USA will talk about "Non-estrogenic xanthohumol derivatives improve cognitive function in diet-induced obese mice" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 26-28, 2018.

According to Prof. Stevens:

Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its biotransformation by gut microbiota into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in humans. To address this concern, we evaluated two hydrogenated derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), which showed negligible affinity for estrogen receptors α and β, and which cannot be metabolically converted into 8-PN. Diet-induced obese mice administered XN, DXN or TXN showed improvements of impaired glucose tolerance compared to the controls. DXN and TXN treatment resulted in a decrease of HOMA-IR and plasma leptin. XN, DXN, or TXN treatment ameliorated diet-induced deficits in spatial learning and memory.


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To know more about Bonn Polyphenols 2018 Speakers & Agenda, Please click here

Polyphenols 2021: Submit your abstract & Innovation

innovation-polyphenolsPolyphenols 2021 World Congress invites scientists, academics and industrials to present all their latest Innovations, Technologies and Researches related to Polyphenols. Please submit your innovation and abstract by August 14, 2021.

To register for Polyphenols 2021, please follow this link.


The University of Bonn will host the 12th World Congress on Polyphenols from September 25 to 28, 2018

congress-venueThe International Society of Antioxidants in Nutrition and Health (ISANH) and the Scientific Committee of Polyphenols Congress are pleased to announce the organization of the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 to be held at the University of Bonn, Germany in September 25-28, 2018.

The scientific program is under preparation and all the information will be available on

Please don't hesitate to leave your email address on the contact form if you would like to be informed about all the updates.


Vienna Polyphenols International Conference 2017 was a huge success and gather more than 300 attendees

Polyphenols Group Picture2

The 11th International Conference on Polyphenols Applications took place in Vienna, Austria, from June 20 to June 21, 2017 under the auspices of the International Society for Antioxidants in Nutrition and Health (ISANH).

Prof. Andreas Schieber, President of Vienna Polyphenols 2017, Prof. Marvin Edeas, President of ISANH, and Prof. Doris Marko the local organizer from the University of Vienna welcomed more than 300 academics and industry representatives from 29 countries at University of Vienna.


Silvateam Wins Innovation Award at Polyphenols Congress

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Silvateam was very pleased to participate to the 11th World Congress on Polyphenols Applications: Vienna Polyphenols 2017. The event was organised by the International Society of Antioxidants in Nutrition and Health (ISANH) and the Scientific Committee in the beautiful city of Vienna, Austria, on June 20-21, 2017.

Silvateam, recognised worldwide as leader in the production and sales of tannins since 1854, took actively part in the congress, providing a gold sponsorship and presenting its wide tannin portfolio in a dedicated stand.

During its 160 years of history the company has acquired an extensive experience and technical knowledge in extracting only the best of nature and providing sustainable, cost-effective, multi-purpose solutions for a wide variety of uses, ranging from leather tanning, through nutraceuticals, to functional food, wine and beer, cosmetics, pharma, animal health & nutrition, agriculture and many other applications.

Research & Development plays a key role in all polyphenols related sectors, therefore Silvateam has always invested in both basic and application oriented research. The research is carried out not only in-house, but also in the most prestigious independent institutes such as universities and research centres in Europe, the Americas and Asia. One of this study, investigating the role of tannins as antibiotic alternative in animal nutrition, has been presented during the conference. Participating to this renowned event has been a unique occasion to meet a lot of illustrious experts and start discussing further co-operation opportunities.

At the end of the congress, the organiser awarded Silvateam a prize for its highly innovative solutions in tannins. An expert panel carried out a technical assessment in order to select the best innovations related to polyphenols application fields.

The innovation prize awarded to Silvateam was due to its ability to promote tannins as natural polyphenols in a wide range of applications using various plant sources, such as chestnut, quebracho, tara, gallnuts, grape and other exotic woods, widely available in nature. The direct access and strict control over raw materials allows Silvateam to guarantee the quality, availability and sustainability of its products. The extraction process is eco-friendly, as simple as making a nice cup of tea. The wood is chipped and infused in hot water to obtain a liquid tannin. After evaporation of water, tannin in powder form is commercialised all over the world.

Silvateam management was delighted of the achievement, and even more grateful of receiving recognition from such a competent audience for years of researching innovative techniques, processes and formulations.

You can surely state that nature is part of Silvateam DNA.

Silvateam award

Samuele Giovando, R&D Director at Silvateam, Dr. Mariano E. Fernandez Miyakawa, Researcher at CONICET


More information about Silvateam:

Who attended Vienna Polyphenols 2017?

Unviersity of ViennaMore than 300 stakeholders from the academic, regulatory, industrial sectors, biotech and start-up gathered during Polyphenols Applications 2017 World Congress to discuss many hot topics. Among them:


Vienna Polyphenols 2017 Abstracts Book

Polyphenols 2017 abstract book available for orderThe Abstracts book in PDF version of Vienna Polypenols 2017 is available to order.

If you missed the conference and you would like to order the abstracts book, please click here


If you are member of ISANH & Attendees of Polyphenols 2017, please use following page to download PDF version of Abstracts Book.



Antioxidant and anti - inflammatory potenti al of a pectin depleted apple pomace extract in a pilot human intervention study

Jessica walkerDr Jessica Walker from University of Vienna, Austria will present her studies on "Antioxidant and anti - inflammatory potenti al of a pectin depleted apple pomace extract in a pilot human intervention study" at the 11th World Congress on Polyphenols Applications in Vienne.

According to Dr Jessica Walker, based on the in vitro antioxidant and anti-inflammatory properties of pectin-depleted apple pomace extract (APE4), a human intervention study was performed. Each intervention phase of this placebo controlled pilot study in diabetic and heavily-overweight to obese women spanned over 4 weeks, separated by a 4-week wash-out phase. Upon 4-week intervention with encapsulated APE4, body weight or composition remained unaffected, while endotoxin-stimulated inflammation was reduced.


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The chemistry of gut microbial metabolism of dietary polyphenols

Fred Stevens PolyphenolsProf. Fred Stevens, Professor of Pharmaceutical Sciences at the College of Pharmacy and Director a.i at the Linus Pauling Institute from Oregon State University, USA will present his studies on the chemistry of gut microbial metabolism of dietary polyphenols at the 11th World Congress on Polyphenols Applications in Vienne. 

According to Professor Stevens epidemiological evidence suggests a positive relationship between intake of polyphenol-rich foods and health. However, experimental evidence from preclinical models has not provided a satisfactory explanation for the health-promoting effects of dietary polyphenols in humans. The research community has begun to recognize the impact that gut microbiota have on the health benefits of polyphenols. Not only do gut microbiota affect bioavailability of dietary polyphenols but also their biological activity, because polyphenol-derived metabolic products often have biological properties that are different from the parent polyphenols. Therefore, knowing how gut microbiota metabolize polyphenols is as important as knowing how bioavailable polyphenols affect the health of the host.

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Dietary Polyphenols: Nrf2, epigenetics and in vivo efficacy

Tony Kong PolyphenolsPr Ah-Ng Tony Kong from the Center for Epigenomics of Natural Products, Ernest Mario School of Pharmacy, Rutgers University at Piscataway, USA will give a presentation about Dietary Polyphenols: Nrf2, epigenetics and in vivo efficacy during Vienna Polyphenols World Congress 2017.

According to Pr Kong: "Imbalance between reactive oxygen species (ROS)/reactive nitrogen species (RNS) and the anti-oxidative stress defense systems in cells creates excessive oxidative stress and inflammatory conditions that drive many diseases including cancer. ROS/RNS or carcinogen metabolites can attack intracellular lipids, proteins, nucleic acids, and other macromolecules which can result in epigenetic modifications, genetic mutations, and carcinogenesis. Nrf2, a master regulator of antioxidant defense system plays a critical role in the regulation of many antioxidative stress/antioxidant and detoxification enzymes, such as glutathione S-transferases (GSTs), NAD(P)H:quinone oxidoreductase 1 (NQO1), UDP-glucuronyl transferases (UGTs), and heme oxygenase-1 (HO-1), via the antioxidant response element (ARE). Numerous studies have shown that many dietary phenolic phytochemicals possess anti-cancer preventive property through the induction of Nrf2-mediated antioxidant/detoxification enzymes coupled with the anti-inflammatory signaling pathways that protect organisms against cellular damages caused by oxidative stress. [...] Discussions will include the failure of some polyphenols to activate the Nrf2 system, apparent lack of in vivo efficacy and failed clinical trials."


About Pr Kong: Ah-Ng Tony Kong is Distinguished Professor, Glaxo Endowed Chair Professor of Pharmaceutics and Director of the Graduate Program in Pharmaceutical Sciences at Rutgers, The State University of New Jersey. He is the Director of a new Center for Epigenomics of Natural Products on Inflammatory Diseases. Dr. Kong received his B.S. in Pharmacy with First Class Standing from the University of Alberta, Canada and his Ph.D. in Pharmaceutics, Pharmacokinetics and Pharmacodynamics from the State University of New York at Buffalo. He received his post-doctoral training in molecular genetics and cellular signaling at the National Institutes of Health (NIH). He was on the faculty of Thomas Jefferson University Medical School and the University of Illinois at Chicago prior to joining Rutgers in early 2001. Dr. Kong serves on the NIH Study Section since 1999 and he has been continued receiving funding support from the NIH since 1993. He has trained more than 50 visiting professors, post-doctoral fellows, and Ph.D. students. He has published more than 230 original research, review articles and book-chapters. He has chaired and given presentations in many National and International Symposia. He teaches in Pharmacy and Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics and Drug Metabolism to the PharmD and Ph.D./M.S. Students. He is the Founding Editor-in-Chief of the online journal Current Pharmacology Reports (Springer), Associate Editor of Molecular Carcinogenesis, and member of editorial advisory boards of many journals including Cancer Prevention Research (AACR), Scientific Reports (Nature), and Biopharmaceutics and Drug Disposition. His research areas are in dietary & Traditional Chinese Medicine phytochemicals (signaling and gene expression, nutrigenomics, epigenomics, cancer prevention), animal cancer models, epigenetics, oxidative/redox/inflammatory stress response and Nrf2-mediated nuclear transactivation & signaling, pharmacokinetics/pharmacodynamics and PK-PD modeling of phytochemicals.

Molecular basis of the specificity and efficacy of resveratrol against cancer

wolfgang graier polyphenols 2017Professor Wolfgang F. Graier from the Institute of Molecular Biology and Biochemistry and Medical University of Graz, will give a talk at the 11th World congress on Polyphenols Applications about the molecular basis of the specificity and efficacy of resveratrol against cancer.

According to Prof. Graier, resveratrol and its derivate piceatannol are found to selectively cancer cell death.Professor Graier team work concentrated on the molecular mechanisms of this cancer selectivity. They observed that the functionally and/or physically tethering of the mitochondria to the endoplasmatic reticulum is greatly enhanced, thus, leading to an attenuated engagement of mitochondria to the cancer cells energy metabolism and ER ATP homeostasis.

The polyphenols take advantage of the enforced inter-organelle coupling and trigger apoptotic cancer cell death by their rather exclusive reduction of mitochondrial ATP content that affects ER Ca2+ handling yielding mitochondrial Ca2+ overload and subsequent cancer cell death.

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Valorization of agri-food by-products by extracting valuable bioactive compounds using green processes

Krasimir Dimitrov Polyphenols congress

Dr Krasimir Dimitrov, from the Charles Violette Institute at Lille University, France is invited during Vienna Polyphenols World Congress to give a talk about the valorization of agri-food by-products by extracting  valuable bioactive compounds using green processes.

During his presentation, Dr Dimitrov will highlight the main green extraction processes applied for recovery of bioactive compounds from agri-food by-products, such as
enzyme-assisted extraction (EAE), ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), pressurized liquid extraction (PLE) and supercritical fluid extraction (SFE) are presented, as well as some processes, such as pulsed electric fields (PEF) and high voltage electrical discharges (HVED) that could be applied both in pretreatment stage and during the extraction process.

Another pretreatment process, instant controlled pressure drop (DIC process), allowing to enhance considerably the extraction process is also described. For each process, will be discribed the principle and some examples of its application for recovery of valuable bio-molecules (mainly polyphenols) from agri-food by-products. The green impact of each process is related to the “6 principles of the green extraction”.

Finally, some examples of simultaneous application of at least two processes (hybrid extraction processes) and process integration allowing to enhance the extraction yields and to obtain enriched natural extracts at reduced time and energy (integrated processes)will be presented. 

To know more about these techniques, come & join Vienna Polyphenols 2017:


A response to quercetin-exposure: dendritic cells iron export as the first step towards tolerance

Stefania de Santis polyphenolsDoctor Stefania De Santis from ISPA-CNR in Lecce,Italy, will give a talk at the 11th World Congress on Polyphenols Applications.

According to Doctor De Santis, plant polyphenols consumption is encouraged in healthy dietary regimes due to their antioxidants and anti-inflammatory effects.
These organic molecules exhibit numerous properties including phytochelation; the ability to create complex with metal ions. Among polyphenols, the team of Doctor De Santis focused their attention on quercetin demonstrating its ability to reduce dendritic cells (DCs) inflammatory cytokine secretion and antigen presentation following LPS exposure in vitro and in vivo.

Recently, they demonstrated that quercetin exerts these functions by affecting DCs iron homeostasis. After quercetin exposure, DCs export iron in the extracellular compartment and, at the same time, induce a genes pathway related with iron homeostasis and inflammatory suppression. Future studies are needed to address if administration of natural bio-chelators can reduce inflammatory cytokine secretion by intestinal resident macrophages and DCs, a crucial step to promote the resolution of inflammation and tissue repair.

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Sirtuins, a promising target in slowing down the ageing process; regulatory role of polyphenols

Anna Bielak polyphenols 2017Dr Anna Bielak-Żmijewska from the Laboratory of Molecular Basis of Ageing, the Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland, will give a talk at the 11th World Congress on Polyphenols Applications about the role of sirtuins, called the enzymes of youth, in the regulation of cellular senescence and ageing, and the role of polyphenols in activation of these enzymes.

Aging is an inescapable/unavoidable process. However, the existing data prove that it is malleable and can be effectively slowed down. Ageing is characteristic for almost all living organisms. We are getting older because our cells senesce. Cellular senescence leads to increased low grade inflammation and impairs proper functioning of tissues and organs. One of the promising targets for anti-aging medicine are sirtuins, enzymes strongly involved in DNA repair, telomere maintenance, epigenetic modification of both histones and DNA, and in regulation of many processes involved in homeostasis maintenance in the whole organism. Searching for activators of these enzymes is currently one of the most promising elements of anti-aging strategy and one of the least invasive approaches. It is suggested that some polyphenols are full of promise as activators of sirtuins.

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Curcumin in combination with chemotherapy: Presentation of the CUFOX story

Lynne Howwels polyphenols 2017

During Vienna Polyphenols World Congress, Dr Lynne Howells from University of Leicester will present the recent study concerning Curcumin in combination with chemotherapy.

According to Dr Howeels: "Combining low toxicity polyphenolic adjuncts with standard-of-care chemotherapy may offer added benefit to patients without increasing side effect burdens. Here, we have taken a bench to bedside approach, examining the effects of curcumin in combination with oxaliplatin-based therapy in colorectal cancer. Promising in vitro and pre-clinical data has led to the work-up of the CUFOX phase I/IIa trial, combining curcumin with FOLFOX-based chemotherapy in patients with metastatic colorectal cancer."

The results of this study will be presented during Vienna Polyphenols World Congress:


What are the risks and benefits of conducting realistic research on polyphenols?

Pedro Mena polyphenols congressDr. Pedro Mena, from The Laboratory of Phytochemicals in Physiology, Department of Food & Drug, University of Parma, Italy, will give a talk at the 11th World Congress on Polyphenols Applications about the risks and benefits of conducting realistic research on polyphenols.

Experimental realism refers to adhering to physiological conditions when performing research on polyphenols. This should be kept in mind at all research levels, from cell studies to human interventions. Dosages, molecules, experimental designs, etc., should all be built over physiological assumptions in order to make polyphenol research translatable and really useful. By risking a little more in polyphenol research, we (researchers and humans) will benefit a lot!

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Polyphenols in the News & Media

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