News Alert
Discoloration Caused by Interactions Between Flavonoids and Iron
Dr. Jean-Paul Vincken, from Wageningen University & Research, The Netherlands, will join us this year to present a talk entitled “Discoloration Caused by Interactions Between Flavonoids and Iron”.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Vincken.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Chemical and Sensory Evaluation of Astringency Modulation in Red Wine
Dr. Fabian Weber, University of Bonn, Germany, will join Polyphenols Applications 2022. He will give a talk on the "Chemical and Sensory Evaluation of Astringency Modulation in Red Wine".
Besides the color, the mouthfeel and astringency are the most relevant quality aspects of red wine. Anthocyanins are the coloring principle and tannins are the key compounds for astringency.
Both compounds are extracted from the grapes during winemaking and both compounds are subjected to extensive structural changes during wine ageing. The corresponding reactions that lead to a stable color and an attenuated astringency are closely related and are affected by the wine matrix.
The goal of Dr. Weber's study was to understand the role of polysaccharides in grapes and wine regarding the formation of polymeric pigments and the masking of astringency.
Join the congress this June in Valencia & Online to learn more about the sensory properties of polyphenols in different matrices.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Innovative Processes for Berry Juice Production and Side Stream Valorization
Ms. Nicole Nemetz, University of Bonn, Germany, will join Polyphenols Applications 2022 to present recent advances on the "Innovative Processes for Berry Juice Production and Side Stream Valorization".
She will talk about strategies for the optimization of the juice production (use of ultrasoud) as well as about the recovery of berry pomace in the food industry (seed oil, coloring foodstuff, fruit bars, granola).
Join us in Polyphenols Applications 2022 to know more about the technological innovations in polyphenols extraction and valorization.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Gas Chromatography-Mass Spectrometry Analysis of Cannabinoids: Chemical Diversity Across a Range of Feral Cannabis Plants
Dr. Luke Busta, from University of Minnesota Duluth, USA, will join us this year to present a talk entitled “Gas Chromatography-Mass Spectrometry Analysis of Cannabinoids: Chemical Diversity Across a Range of Feral Cannabis Plants”. He will be participating in the Polyphenols Cannabis workshop on September 30, 2022.
Gas chromatography-mass spectrometry (GC-MS) is a widely accessible technique that can provide considerable analytical information.
Here, Dr. Busta develops a relatively high-throughput method for cannabinoid analysis using GC-MS and use that method to assess cannabinoid diversity across 28 feral cannabis plants.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Luke Busta.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Methods of Quantitative Analysis for Cannabinoids in Industrial Hemp
Dr. Jennifer Duringer, from Oregon State University, USA, will join us this year in the Polyphenols Cannabis Workshop to present a talk entitled “Methods of Quantitative Analysis for Cannabinoids in Industrial Hemp”.
Quantitative measurement of cannabinoids in industrial hemp is important for both regulatory and research purposes as researchers begin to uncover the potential of Cannabis and its products for human and animal health. Sample collection, preparation, extraction and analytical detection (LC-DAD and LC-MS/MS) will be discussed along with best practices for quality assurance/quality control.”
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Jennifer Duringer.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Towards the Utilization of Cannabinoids as Anticancer Agents
Dr. Guillermo Velasco, from Instituto de Investigación Sanitaria San Carlos, Spain, will join us this year to present a talk entitled “Towards the Utilization of Cannabinoids as Anticancer Agents”.
A large body of evidence shows that cannabinoids, in addition to their well-known palliative effects on some cancer-associated symptoms, can reduce tumour growth in animal models of cancer and specifically of gliomas. The mechanism of cannabinoid anticancer action relies, at least largely, on the ability of these agents to stimulate autophagy-mediated cancer cell death. Moreover, the combined administration of cannabinoids and temozolomide produces a strong anticancer effect, which correlates with an intense activation of the signalling route that triggers the activation of cytotoxic autophagy.
Research conducted in Dr. Velasco's group has also led to the identification of mechanisms of resistance to cannabinoid anticancer action. For example, up-regulation of the growth factor Midkine (MDK) promotes resistance to cannabinoid anticancer action in gliomas via stimulation of the Anaplastic Lymphoma Kinase tyrosine kinase receptor (ALK); and could be a factor of bad prognosis in GBM patients. All these preclinical findings have facilitated the promotion of clinical studies to investigate the safety and efficacy of the combined administration of THC+CBD and temozolomide in GBM.
In this presentation Dr. Velasco will briefly discuss these issues and other possible future studies that may help to clarify whether cannabinoids may be useful as anticancer agents in patients with gliomas or other cancers.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Velasco.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Inhibition Mechanism of Catechins on Dietary AGEs Absorption and Toxicity
Dr. Qian Wu, from Hubei University of Technology, China, will join us this year to present a talk entitled “Inhibition Mechanism of Catechins on Dietary AGEs Absorption and Toxicity”.
In her study, using a simulated gastrointestinal digestion model, Dr. Wu showed that catechin efficiently inhibited the digestion of oligopeptide-AGEs. A mass-spectrometry- (MS) based proteomics approach (Q Exactive) was applied to identify the digestion products of glycated bovine serum albumin (BSA), and three oligopeptide-AGEs was found, including FWGK(160)-CML, LSQK(245)FPK-CML, WSVAR(221)LG-H1. No free AGEs were detected indicated that the digested glycated protein existed in the form of oligopeptide-AGEs. Addition of catechin as inhibitor, a significant decline in the fluorescence intensity of glycated protein, the degree of hydrolysis and free amino acids were observed and the particle size of the digestion products increased, which could indicate the inhibitory effects of catechin on the release of AGEs during gastrointestinal digestion.
Using Caco-2 cell model, we found that catechins could effectively inhibit the absorption of oligopeptide-AGEs and the expression of oligopeptide-transportor (PEPT1) and tight junction protein (ZO-1). The expression of ZO-1 in Caco-2 cells could be determined by immunohistochemical staining, and the results suggested that adding catechin could significantly increase the expression of ZO-1 (P< 0.05). Caco-2 cells were induced with BSA-AGEs digests for 24 h, and it was indicated that 20 µm and 50 µm catechins could reduce the expression of PepT1 by 53.8% and 73.1%, respectively (P< 0.01). In addition, molecular docking method was used to compare the binding ability of catechin to three oligopeptides-AGES (FWGK(160)-CML, LSQK(245)FPK-CML, WSVAR(221)L-G-H1) and PepT1, and it was found that catechin was easier to bind to PepT1. Therefore, the transport capacity of PepT1 to oligopeptide-AGEs was decreased.
It was found that the activation of RAGE receptor in rat liver were inhibited and the liver damage caused by dietary AGEs were reduced by catechin in rat model. SPF Rats were divided into four groups: normal diet (N), high-dose AGEs diet (H), 0.2% catechin supplemented diet (0.2%) and 0.5% catechin supplemented diet (0.5%), respectively. The expressions of RAGE, p38MAPK and NF-κB in the liver of the rats were detected by immunochemistry staining. The results showed that the activation of RAGE-p38MAPK-NF-κB signaling pathway was significantly inhibited by 0.5% catechin (p＜0.01).The expressions of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) genes in liver were detected by RT-PCR, and the results showed that the expression of inflammatory cytokines could be significantly decreased by 0.2% and 0.5% catechin.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Wu.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Effects of Berry (Poly)phenols on Cardiovascular Health: Clinical Evidence and Mechanistic Insights
Dr. Ana Rodriguez-Mateos, from King's College London, United Kingdom, will join us this year to present a talk entitled “Effects of Berry (Poly)phenols on Cardiovascular Health: Clinical Evidence and Mechanistic Insights”.
Berries are getting increased attention due to their potential cardiovascular health benefits. However, which bioactives in berries are responsible for the effects and the mechanisms of action in the vascular system are currently unknown. Dr. Rodriguez-Mateos will discuss the recent clinical studies she has conducted investigating the effect of different berries and berry (poly)phenol extracts on cardiovascular function. You can find more information on Dr. Rodriguez-Mateos research here.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Rodriguez-Mateos.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Polyphenols and Extracellular Vesicles: A New Revolution?
Dr. Ramaroson Andriantsitohaina, from France, will join us this year to present exclusively and for the first time a talk on “Polyphenols and Extracellular Vesicles: A New Revolution?”.
Extracellular vesicles have been well reported as a novel mean of cell-to-cell communication in physiology and pathology.
Dr. Andriantsitohaina was recently the first to prove that polyphenols can act on signaling pathways that interfere with the EVs biogenesis (release and content), and are thus able to control cells' functional properties.
He points out that the combination of polyphenols and EVs can increase their therapeutic potential, for instance:
- Plants are able to produce EVs that encapsulate natural components from vegetables, polyphenols for instance
- Mammalian cells can be treated with polyphenols and the subsequent EVs produced are enriched in these components
- EVs from mammalian cells can be uploaded with polyphenols.
Join us in Polyphenols Applications 2022 and be the first to listen to Dr. Andriantsitohaina review the novel aspects of the interplay between polyphenols and EVs and its potential health benefits in cancer, cardiovascular, metabolic and neurodegenerative diseases.
Don't miss the chance! Book your spot.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Wine Polyphenols and Gut Microbiota
Dr. Nenad Naumovski, from University of Canberra, Australia, will join us this year to present a talk entitled “Wine Polyphenols and Gut Microbiota”.
This presentation will include the latest findings from observational studies relating to the wine consumption and its effect on gut microbiota. Furthermore, Dr. Naumovski will also discuss the consumption of wine polyphenols and their implications in health.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Naumovski.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Conversion of Phenolic Compounds in Food Fermentations by Lactic Acid Bacteria: Metabolic Pathways and Functional Metabolites
Dr. Michael Gänzle, from the University of Alberta, Canada, will join us this year to present a keynote presentation on “Conversion of Phenolic Compounds in Food Fermentations by Lactic Acid Bacteria: Metabolic Pathways and Functional Metabolites”.
Dr. Gänzle's presentation will present current knowledge on metabolic pathways for conversion of phenolic compounds by lactic acid bacteria, and indicate which conversions have been described in food fermentations.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Gänzle.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Molecular Taste: Molecular Approaches to Understand Food Polyphenols Astringency and Bitterness
Dr. Susana Soares, from Faculdade de Ciências da Universidade do Porto (FCUP), Portugal, will join us this year to present a talk entitled “Molecular Taste: Molecular Approaches to Understand Food Polyphenols Astringency and Bitterness".
As per Dr. Soares, phenolic compounds (PC) are linked to astringency sensation and bitter taste. Regarding astringency, studies typically use simple models, with pure PC and/or proteins, far from what is likely to occur in the oral cavity. Different oral models have been developed in our last works, comprising different oral epithelia (buccal mucosa (TR146) and tongue (HSC-3)) and other main oral constituents (human saliva and mucosal pellicle). These models have been used to study the interaction with more or less complex PC extracts as well as with food matrices, such as coffee. The studied extracts were rich in different families of (food) PC, namely flavanols (a green tea extract), anthocyanins (a red wine extract), gallotannins (a tannic acid extract), and flavonols (an onion extract). It was observed a different interaction for the different families of PC and also that the several oral constituents have different implications. Moreover, some of these studies aligned the in vitro models with sensory studies data. Overall, the results seem to point out that the different oral constituents can have different functions in astringency perception as well as being involved in different phases of astringency perception. These differences can be related to the perception of different astringency sub-qualities.
Regarding bitterness, Dr. Soares and her team have used a cell-based assay to screen which human bitter taste receptors are activated by a library of PC from different families. The bitter taste receptors (TAS2Rs) activated by these polyphenols and the half-maximum effective concentration (EC50) of each agonist-TAS2Rs pair were determined. TAS2R5 seems to be the only receptor somehow “specifically” activated by natural (condensed) tannins, while TAS2R7 seems more tuned for hydrolysable (ellagi)tannins. Additionally, at the concentrations usually found for these compounds in foodstuffs, they can actively contribute to bitter taste, especially ETs. Ultimately, it seems that when considering the bitterness of polyphenols, bitterness and astringency sensory properties seem to be undeniably linked, especially to explain and compare in vitro and in vivo inconsistencies.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Soares.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Ion Mobility–Mass Spectrometry in Food Analysis
Dr. Sonia Sentellas, from the University of Barcelona, Spain, will join us this year to present a talk entitled “Ion Mobility–Mass Spectrometry in Food Analysis”.
Ion mobility spectrometry (IMS) has emerged as a powerful alternative to classical separation techniques. IMS has been extensively used in a wide range of research areas, however, until now, it has been scarcely applied in food analysis.
In this sense, the separation of polyphenols in food matrices based on their differential mobility opens excellent possibilities for food authentication.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Sentellas.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Flavan-3-ols Induces Browning of Adipose Tissues through Sympathetic Nerve Activation
Dr. Naomi Osakabe, from the Shibaura Institute of Technology, Japan, will join us this year to present a talk entitled “Flavan-3-ols Induces Browning of Adipose Tissues through Sympathetic Nerve Activation”.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Osakabe.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Impact of Berries, Cherries and Quinoa Polyphenols on Gut Microbiota & Health
Dr. Franck Carbonero, from the Washington State University-Spokane, USA, will join us this year to present a talk entitled “Impact of Berry and Quinoa Polyphenols on Gut Microbiota & Health”.
It is now well established that bioavailability and bioactivity of a significant fraction of dietary polyphenols are directly modulated by the gut microbiota.
A better understanding of both the impact of polyphenol on gut microbiota profiles and the fate of microbial phenolic metabolites is primordial to optimize nutritional strategies relying on polyphenols expected antioxidant properties. Furthermore, considering the whole polyphenol-rich foods should become the gold standard, as the complete physiochemical properties of the food matrix also influences the polyphenol/microbiome/host interactions.
Dr. Carbonero will present his most recent findings on the impacts of polyphenols from berries, cherries and quinoa on the gut microbiota as informed by in vitro, animal and human studies.
You can find more information on Dr. Carbonero's research and publications on his website: https://labs.wsu.edu/ngmb/
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Micellar Formulations Enhance the Post-Digestive Solubility and Bioavailability of (Poly)phenols
Dr. Jan Frank, from the University of Hohenheim, Germany, will join us this year to present a talk entitled “Micellar Formulations Enhance the Post-Digestive Solubility and Bioavailability of (Poly)phenols”.
The bioavailabilities of (poly)phenols are determined by their digestive stability, absorption in the small intestine, their subsequent biotransformation, and distribution in or elimination from the organism.
Different strategies targeting some of these processes have been developed to enhance the bioavailabilities of (poly)phenols, but only a few have been successful.
Dr. Frank will present his most recent findings on successful formulation strategies to enhance the oral bioavailabilities of (poly)phenols in humans and on the potentially underlying mechanisms of action.
You can find more information on Dr. Frank's research and publications on his website: www.nutrition.red
Join us in polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Frank.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Antioxidant Activity and Phenolic Composition of Extracts Obtained from Microalgae After the Application of Innovative Processes
Dr. Francisco Juan Martí-Quijal, from the University of Valencia, Spain, will join us this year to present a talk entitled “Antioxidant Activity and Phenolic Composition of Extracts Obtained from Microalgae After the Application of Innovative Processes”.
Microalgae are an important source of nutrients and bioactive compounds (e.g. polyphenols), and therefore can be considered as interesting ingredients in the development of new functional foods and nutraceutical products. Different extraction methods can be used to obtain microalgae compounds with high added value. In this sense, non-conventional extraction technologies like pulsed electric fields, supercritical fluids extraction, and enzymatic extraction, among others, can be useful to make this process more sustainable since conventional extraction methods can be slow, consume large amounts of solvent, work at high temperatures, or extract unwanted compounds. Treatment and extraction conditions can influence the phenolic profile and antioxidant activity of the obtained extracts.
Join us in Polyphenols Applications 2022 to know more about this topic.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Innovative Technologies for the Extraction of Antioxidant Bioactive Compounds from Mushrooms
Ms. Mara Calleja, from the University of Valencia, Spain, will join us this year to present a talk entitled “Innovative Technologies for the Extraction of Antioxidant Bioactive Compounds from Mushrooms”.
In recent years, the growing production and consumption of mushrooms has led to an increase in research on this food group, both as a source of bioactive components and as additives for the formulation of supplements and nutraceuticals. Bioactive compounds such as polyphenols present in mushrooms show antioxidant properties and the ability to interact with components of the organism being useful for the design of new therapeutic agents.
For this reason, new sustainable extraction methods are being sought, such as Pulsed Electric Field-Assisted Extraction, which increases the quality of the extract and saves energy. This method is applied in the extraction of antioxidant compounds in samples of A. bisporus, L. edodes, A. brunnescens and P. ostreatus, also affecting the microstructure, which is evaluated by scanning electron microscopy.
Join us in Polyphenols Applications 2022 to know more about this topic.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Recovery of Polyphenols from Medicinal Plants Extracts Assisted by Pulsed Electric Fields
Dr. Noelia Pallarés, from the University of Valencia, Spain, will join us this year to present a talk entitled “ Recovery of Polyphenols from Medicinal Plants Extracts Assisted by Pulsed Electric Fields”.
Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Pallarés.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
Chemistry and Pharmacology of Cannabinoids
Dr. Jan Frederik Stevens, from Oregon State University, USA, will join us this year to present his most recent findings on “Chemistry and Pharmacology of Cannabinoids”, during Cannabis 2022 workshop.
He will share his newest work and his vast knowledge on Cannabinoids from a pharmacological perspective.
Remember that you too can participate in Cannabis 2022 by submitting your abstract here.
Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com
More Articles...
- Inhibition of Oxytosis/Ferroptosis by Cannabinol Requires Mitochondria and is Independent of Cannabinoid Receptors
- Ocular Delivery of Polyphenols
- Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases
- Best Oral Presentations of Polyphenols Applications 2021
- Best Poster Presentations of Polyphenols Applications 2021
- Best Scientific Award of Polyphenols Applications 2021
- Beneficial Effects of Cornelian Cherry polyphenols on NO/ROS Balance in Obese Zucker Rats
- Polyphenols Applications: Neutraceutical Interventions for Peripheral Artery Disease
- Secoiridoids from Gentiana Lutea: Interaction with Bitter Receptors in the Gastrointestinal Tract and Enteroendocrine Pharmacological Application
- Polyphenols Metabolites & Mitochondrial Function in Health and Disease
