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Why biotransformation matters: species differences in isoflavone metabolism and biological implications

Sebastian-Soukup-Bonn-Polyphenols-2018

Dr. Sebastian Soukup from the Max Rubner-Institut, Germany will discuss the topic "Why biotransformation matters: species differences in isoflavone metabolism and biological implicationsduring the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

Summary of talk: "Isoflavones are associated with beneficial health effects such as the alleviation of menopausal symptoms and the prevention of osteoporosis, but are also discussed to have proliferative effects on ER-sensitive breast cancer.
To investigate physiological effects of bioactive compounds, animals models are widely used. Since species differences in metabolism can lead to changes in bioactivity and biokinetic behaviour of the compounds investigated, they have to be considered when extrapolating results to the human situation. In this presentation, analytical aspects of biotransformation studies as well as recent findings about isoflavone metabolism in different animal models and humans will be outlined and their biological implications discussed."
 

For more information: www.polyphenols-site.com

 

Pineapple (Ananas comosus (L.) Merr.) as a source of unique phenolic compounds: analysis and applications as authenticity markers

Steingass-C.B-Bonn-Polyphneenols-2018-updatedProf. Christof Steingass from University of Hohenheim, Germany will give presentation entitled "Pineapple (Ananas comosus (L.) Merr.) as a source of unique phenolic compounds: analysis and applications as authenticity markers" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

Prof. Steingass will present the LC-MS analysis of unique phenolic compounds in the pineapple infructescence as well as their applications as authenticity markers for pineapple juice obtained from different fruit fractions (i.e., edible flesh, flesh adhered to the shell, and milled peel).

For more information: www.polyphenols-site.com

 

The effects of novel processing technologies on the stability of polyphenols

Isabel Odriozola-Bonn-Polyphenols-2018Prof. Isabell Odriozola Serrano from university of Lleida, Spain will present her study on "The effects of novel processing technologies on the stability of polyphenols" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

The aim of this presentation is to provide an update on the state of the art of novel processing technologies with special focus on the impact of pulsed electric fields, high pressure and pulsed light treatments on the stability of polyphenols in plant-based foods. The main advantages as well as some critical points of the introduction of novel processing technologies to keep/improve the antioxidant potential of plant-based foods will be discussed.

 

For more information: www.polyphenols-site.com

Polyphenols and natural pigments: what are the food & beverages applications?

Polyphenols-pigments-updatedThe Scientific Committee of Bonn Polyphenols 2018 decides to allocate more time to discuss about Polyphenols as natural pigments and additives, and their applications in the food & beverage industries. This special session is organize on September 28.

The industrials from Food & beverage look to replace synthetic colorants with more respectful natural pigments. However many barriers remain in term of extraction, stabilization and industrial applications.

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Polyphenols and chronic disease risk: epidemiological perspectives

Ute Nöthlings Bonn Polyphenols 2018Prof. Ute Nöthlings, Professor for Nutritional Epidemiology at the Department of Nutrition and Food Sciences, Bonn University, will present an overview over recent epidemiological studies investigating associations between polyphenol exposure and chronic disease risk during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

Epidemiological studies play a role in exploring associations of polyphenol and polyphenol-rich food intake and risk of chronic diseases, and ultimately back evidence based dietary recommendations. Evidence exists showing inverse associations for diabetes mellitus type 2, cardiovascular diseases, cancer and neurodegenerative disease, but heterogeneity exists. Important aspects when evaluating the evidence are study designs and assessment of exposure. The talk will give an overview over recent evidence, with a focus on specific methodological perspectives.

 

For more information: www.polyphenols-site.com

 

Processing as a modifier of polyphenol delivery and bioactivity

ferruzzi-polyphenols 2018Prof. Mario Ferruzzi from North Carolina State University, Kannapolis, USA will give a presentation entitled "Processing as a modifier of polyphenol delivery and bioactivity" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

Summary:  As evidence mounts for a health-protective role for dietary polyphenols, the importance of understanding factors that modify the delivery of specific polyphenol metabolites to target tissues has increased.  Food formulation and processing are believed to be significant modifiers of polyphenol bioavailability.This lecture will present data from our past and ongoing efforts focused on understanding food matrix and processing parameters as they intersect with select physiological factors to impact absorption, metabolism and tissue distribution of polyphenols.

For more information: www.polyphenols-site.com

Phenolic compounds in Food waste valorization: figures and perspectives

Richard Maroun Bonn Polyphneols 2018

During the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018, Prof. Richard Maroun from Saint-Joseph University of Beirut, Beirut, Lebanon will give presentation about "Phenolic compounds in Food waste valorization: figures and perspectives".

According to Prof. Richard Maroun: "Food waste valorization practices have gained much attention lately as a means of sustainable management. These materials constitute an underexploited source for the recovery of natural compounds. The value of food byproducts is associated with their content in dietary fibers and several bioactive molecules which can be capitalized in the food, pharmaceutical, cosmetic and nutraceutical industries. One of the main molecules extracted and purified are polyphenols. Our work aims to purify these natural antioxidant molecules through innovative technologies in order to reintegrate them as valuable additives in several industrial applications".

For more information: www.polyphenols-site.com

 

 

Development of microbial production platforms for plant polyphenols

Mattheos Koffas Polyphenols 2018Prof. Mattheos Koffas from Rensselaer Polytechnic Institute, USA will talk about the "Development of microbial production platforms for plant polyphenols" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

According to Prof. Mattheos Koffas: "In the past 15 years, we have applied metabolic engineering towards the development of robust and efficient microbial production platforms for the production of plant polyphenols. We will present a number of examples where single hosts have been optimized for the production of various flavonoids starting from intermediates such as phenylpropanoic acids and flavanones, using stoichiometric-based modeling and metabolic pathway balancing. We will then present examples of using co-cultures involving such individual strains for the de novo production optimization of various flavonoids from glucose."

For more information: www.polyphenols-site.com

Anthocyanins - Color enhancing strategies

prof reinhold-polyphenolsProf. Reinhold Carle from the University of Hoheneim will present his work about "Anthocyanins – Color enhancing strategies" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

Apart from taste, aroma and texture, color is the most important attribute determining consumer acceptance. Many foods are colored to compensate for color losses due to harsh processing conditions and long-term storage. Furthermore, unappealing visual perception of colorless food is meliorated by the addition of artificial and natural pigments. Owing to their low cost, high stability and superior tinctorial strength, usage of synthetic and animal-based dyes has prevailed over a long period.

Nowadays, due to growing health consciousness, religious rejection, legal restrictions, and the trend toward vegetarian lifestyle, these are progressively replaced by plant pigments. However, the latter are suffering from a limited color palette, poor heat and light stability, sensitivity against high pH, complexing agents, and oxidation. Most frequently, fruit and vegetable concentrates containing anthocyanins and refined preparations thereof are a natural alternative, when water-soluble pigments producing red to bluish tonalities are demanded.

In his presentation, Prof. Carle will highlight the role and importance of color to enhance strategies.

For more information: www.polyphenols-site.com

 

 

Activity guided fractionation of red fruit juices to identify α amylase and α glucosidase inhibitors in vitro

Kirsten Berger Bonn Polyphenols 2018 v1

Kirsten Berger from University of Kaiserslautern, Kaiserslautern, Germany will talk about "Activity guided fractionation of red fruit juices to identify α amylase and α glucosidase inhibitors in vitro" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 25-28, 2018.

The inhibitory potential of polyphenols against enzymes of the carbohydrate metabolism, such as α‑amylase and α‑glucosidase has been described in some studies. A rich source of polyphenols, especially anthocyanins are red fruits. Our studies examined the in vitro inhibitory activity of extracts and fractions prepared from juices, concentrates, and purees against α‑amylase and α‑glucosidase.

 

For more information: www.polyphenols-site.com

Non-estrogenic xanthohumol derivatives improve cognitive function in diet-induced obese mice

Jan Frederik Stevens - vienna Polyphenols 2018Prof. Fred Stevens from Oregon State University, Corvallis, USA will talk about "Non-estrogenic xanthohumol derivatives improve cognitive function in diet-induced obese mice" during the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 which will be held at the University of Bonn, Germany in September 26-28, 2018.

According to Prof. Stevens:

Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its biotransformation by gut microbiota into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in humans. To address this concern, we evaluated two hydrogenated derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), which showed negligible affinity for estrogen receptors α and β, and which cannot be metabolically converted into 8-PN. Diet-induced obese mice administered XN, DXN or TXN showed improvements of impaired glucose tolerance compared to the controls. DXN and TXN treatment resulted in a decrease of HOMA-IR and plasma leptin. XN, DXN, or TXN treatment ameliorated diet-induced deficits in spatial learning and memory.

 

For more information: www.polyphenols-site.com

To know more about Bonn Polyphenols 2018 Speakers & Agenda, Please click here

Polyphenols 2021: Submit your abstract & Innovation

innovation-polyphenolsPolyphenols 2021 World Congress invites scientists, academics and industrials to present all their latest Innovations, Technologies and Researches related to Polyphenols. Please submit your innovation and abstract by August 14, 2021.

To register for Polyphenols 2021, please follow this link.

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The University of Bonn will host the 12th World Congress on Polyphenols from September 25 to 28, 2018

congress-venueThe International Society of Antioxidants in Nutrition and Health (ISANH) and the Scientific Committee of Polyphenols Congress are pleased to announce the organization of the 12th World Congress on Polyphenols Applications: Bonn Polyphenols 2018 to be held at the University of Bonn, Germany in September 25-28, 2018.

The scientific program is under preparation and all the information will be available on www.polyphenols-site.com

Please don't hesitate to leave your email address on the contact form if you would like to be informed about all the updates.

 

Vienna Polyphenols International Conference 2017 was a huge success and gather more than 300 attendees

Polyphenols Group Picture2

The 11th International Conference on Polyphenols Applications took place in Vienna, Austria, from June 20 to June 21, 2017 under the auspices of the International Society for Antioxidants in Nutrition and Health (ISANH).

Prof. Andreas Schieber, President of Vienna Polyphenols 2017, Prof. Marvin Edeas, President of ISANH, and Prof. Doris Marko the local organizer from the University of Vienna welcomed more than 300 academics and industry representatives from 29 countries at University of Vienna.

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Silvateam Wins Innovation Award at Polyphenols Congress

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Silvateam was very pleased to participate to the 11th World Congress on Polyphenols Applications: Vienna Polyphenols 2017. The event was organised by the International Society of Antioxidants in Nutrition and Health (ISANH) and the Scientific Committee in the beautiful city of Vienna, Austria, on June 20-21, 2017.

Silvateam, recognised worldwide as leader in the production and sales of tannins since 1854, took actively part in the congress, providing a gold sponsorship and presenting its wide tannin portfolio in a dedicated stand.

During its 160 years of history the company has acquired an extensive experience and technical knowledge in extracting only the best of nature and providing sustainable, cost-effective, multi-purpose solutions for a wide variety of uses, ranging from leather tanning, through nutraceuticals, to functional food, wine and beer, cosmetics, pharma, animal health & nutrition, agriculture and many other applications.

Research & Development plays a key role in all polyphenols related sectors, therefore Silvateam has always invested in both basic and application oriented research. The research is carried out not only in-house, but also in the most prestigious independent institutes such as universities and research centres in Europe, the Americas and Asia. One of this study, investigating the role of tannins as antibiotic alternative in animal nutrition, has been presented during the conference. Participating to this renowned event has been a unique occasion to meet a lot of illustrious experts and start discussing further co-operation opportunities.

At the end of the congress, the organiser awarded Silvateam a prize for its highly innovative solutions in tannins. An expert panel carried out a technical assessment in order to select the best innovations related to polyphenols application fields.

The innovation prize awarded to Silvateam was due to its ability to promote tannins as natural polyphenols in a wide range of applications using various plant sources, such as chestnut, quebracho, tara, gallnuts, grape and other exotic woods, widely available in nature. The direct access and strict control over raw materials allows Silvateam to guarantee the quality, availability and sustainability of its products. The extraction process is eco-friendly, as simple as making a nice cup of tea. The wood is chipped and infused in hot water to obtain a liquid tannin. After evaporation of water, tannin in powder form is commercialised all over the world.

Silvateam management was delighted of the achievement, and even more grateful of receiving recognition from such a competent audience for years of researching innovative techniques, processes and formulations.

You can surely state that nature is part of Silvateam DNA.

Silvateam award

Samuele Giovando, R&D Director at Silvateam, Dr. Mariano E. Fernandez Miyakawa, Researcher at CONICET

 

More information about Silvateam: https://www.silvateam.com/en/

Who attended Vienna Polyphenols 2017?

Unviersity of ViennaMore than 300 stakeholders from the academic, regulatory, industrial sectors, biotech and start-up gathered during Polyphenols Applications 2017 World Congress to discuss many hot topics. Among them:

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Vienna Polyphenols 2017 Abstracts Book

Polyphenols 2017 abstract book available for orderThe Abstracts book in PDF version of Vienna Polypenols 2017 is available to order.

If you missed the conference and you would like to order the abstracts book, please click here

order-abstract-book

If you are member of ISANH & Attendees of Polyphenols 2017, please use following page to download PDF version of Abstracts Book.

download-abstract-book-v1

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Antioxidant and anti - inflammatory potenti al of a pectin depleted apple pomace extract in a pilot human intervention study

Jessica walkerDr Jessica Walker from University of Vienna, Austria will present her studies on "Antioxidant and anti - inflammatory potenti al of a pectin depleted apple pomace extract in a pilot human intervention study" at the 11th World Congress on Polyphenols Applications in Vienne.

According to Dr Jessica Walker, based on the in vitro antioxidant and anti-inflammatory properties of pectin-depleted apple pomace extract (APE4), a human intervention study was performed. Each intervention phase of this placebo controlled pilot study in diabetic and heavily-overweight to obese women spanned over 4 weeks, separated by a 4-week wash-out phase. Upon 4-week intervention with encapsulated APE4, body weight or composition remained unaffected, while endotoxin-stimulated inflammation was reduced.

 

For more information, please visit www.polyphenols-site.com

The chemistry of gut microbial metabolism of dietary polyphenols

Fred Stevens PolyphenolsProf. Fred Stevens, Professor of Pharmaceutical Sciences at the College of Pharmacy and Director a.i at the Linus Pauling Institute from Oregon State University, USA will present his studies on the chemistry of gut microbial metabolism of dietary polyphenols at the 11th World Congress on Polyphenols Applications in Vienne. 

According to Professor Stevens epidemiological evidence suggests a positive relationship between intake of polyphenol-rich foods and health. However, experimental evidence from preclinical models has not provided a satisfactory explanation for the health-promoting effects of dietary polyphenols in humans. The research community has begun to recognize the impact that gut microbiota have on the health benefits of polyphenols. Not only do gut microbiota affect bioavailability of dietary polyphenols but also their biological activity, because polyphenol-derived metabolic products often have biological properties that are different from the parent polyphenols. Therefore, knowing how gut microbiota metabolize polyphenols is as important as knowing how bioavailable polyphenols affect the health of the host.

For more information, please visit www.polyphenols-site.com

 

Dietary Polyphenols: Nrf2, epigenetics and in vivo efficacy

Tony Kong PolyphenolsPr Ah-Ng Tony Kong from the Center for Epigenomics of Natural Products, Ernest Mario School of Pharmacy, Rutgers University at Piscataway, USA will give a presentation about Dietary Polyphenols: Nrf2, epigenetics and in vivo efficacy during Vienna Polyphenols World Congress 2017.

According to Pr Kong: "Imbalance between reactive oxygen species (ROS)/reactive nitrogen species (RNS) and the anti-oxidative stress defense systems in cells creates excessive oxidative stress and inflammatory conditions that drive many diseases including cancer. ROS/RNS or carcinogen metabolites can attack intracellular lipids, proteins, nucleic acids, and other macromolecules which can result in epigenetic modifications, genetic mutations, and carcinogenesis. Nrf2, a master regulator of antioxidant defense system plays a critical role in the regulation of many antioxidative stress/antioxidant and detoxification enzymes, such as glutathione S-transferases (GSTs), NAD(P)H:quinone oxidoreductase 1 (NQO1), UDP-glucuronyl transferases (UGTs), and heme oxygenase-1 (HO-1), via the antioxidant response element (ARE). Numerous studies have shown that many dietary phenolic phytochemicals possess anti-cancer preventive property through the induction of Nrf2-mediated antioxidant/detoxification enzymes coupled with the anti-inflammatory signaling pathways that protect organisms against cellular damages caused by oxidative stress. [...] Discussions will include the failure of some polyphenols to activate the Nrf2 system, apparent lack of in vivo efficacy and failed clinical trials."

 

About Pr Kong: Ah-Ng Tony Kong is Distinguished Professor, Glaxo Endowed Chair Professor of Pharmaceutics and Director of the Graduate Program in Pharmaceutical Sciences at Rutgers, The State University of New Jersey. He is the Director of a new Center for Epigenomics of Natural Products on Inflammatory Diseases. Dr. Kong received his B.S. in Pharmacy with First Class Standing from the University of Alberta, Canada and his Ph.D. in Pharmaceutics, Pharmacokinetics and Pharmacodynamics from the State University of New York at Buffalo. He received his post-doctoral training in molecular genetics and cellular signaling at the National Institutes of Health (NIH). He was on the faculty of Thomas Jefferson University Medical School and the University of Illinois at Chicago prior to joining Rutgers in early 2001. Dr. Kong serves on the NIH Study Section since 1999 and he has been continued receiving funding support from the NIH since 1993. He has trained more than 50 visiting professors, post-doctoral fellows, and Ph.D. students. He has published more than 230 original research, review articles and book-chapters. He has chaired and given presentations in many National and International Symposia. He teaches in Pharmacy and Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics and Drug Metabolism to the PharmD and Ph.D./M.S. Students. He is the Founding Editor-in-Chief of the online journal Current Pharmacology Reports (Springer), Associate Editor of Molecular Carcinogenesis, and member of editorial advisory boards of many journals including Cancer Prevention Research (AACR), Scientific Reports (Nature), and Biopharmaceutics and Drug Disposition. His research areas are in dietary & Traditional Chinese Medicine phytochemicals (signaling and gene expression, nutrigenomics, epigenomics, cancer prevention), animal cancer models, epigenetics, oxidative/redox/inflammatory stress response and Nrf2-mediated nuclear transactivation & signaling, pharmacokinetics/pharmacodynamics and PK-PD modeling of phytochemicals.

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