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Best Scientific Contribution Award for Advancing Polyphenols in Oncotherapy at Polyphenols Applications 2024

Prof. José M. Estrela from the University of Valencia has received the Best Scientific Contribution Award at Polyphenols Applications 2024 for his research on “Polyphenols in Oncotherapy: Moving Forward from the Bench to Clinical Applications.” His work addresses the challenge of polyphenols' poor bioavailability in vivo and their potential in cancer treatment.

While polyphenols demonstrate significant anti-cancer effects in preclinical studies—such as inducing cell cycle arrest and inhibiting angiogenesis—issues like limited absorption hinder their clinical application. Prof. Estrela highlights innovative delivery systems, including nanoparticles and liposomes, to enhance bioavailability and efficacy.

About Prof. Estrella

As a professor of physiology and director of the Cell Pathophysiology Unit at the University of Valencia, as well as research director at Scientia BioTech, Prof. Estrela is pioneering new anti-cancer strategies that integrate polyphenols for improved therapeutic outcomes. Congratulations to Prof. Estrela on this well-deserved recognition!

Molecular Mechanisms of Flavan-3-ol Degradation: Best Short Oral Presentation Award at Polyphenols Applications 2024

Pascale Mosoni of INRAE has won the Best Short Oral Presentation Award at Polyphenols Applications 2024 for her research on “The Molecular Basis of the Degradation of Flavan-3-ols by the Human Gut Bacterium Eggerthella Lenta.” 

Dr. Mosoni's presentation delved into how Eggerthella lenta metabolizes flavan-3-ols—polyphenols known for their cardiovascular benefits—into bioactive compounds in the gut. By identifying ten key genes responsible for this metabolic process through a transcriptomic approach, Dr. Mosoni's work has revealed that 27% of individuals lack the ability to convert these polyphenols, raising important questions about cardiovascular risk factors.

About Dr. Mosoni

Dr. Mosoni is a microbiologist in MEDIS (Microbiology, Digestive Environment & Health) laboratory at INRAE. Her research activities are currently focusing on the metabolism/degradation of dietary fibers and polyphenols by the human gut microbiota in order to better understand the effects of these plant dietary components on health through the action of the microbiota. The approaches used involve the isolation of anaerobic microorganisms contributing to these metabolic pathways and characterize their function (genes, enzymes, metabolites) and role in health.  Her aim is to discover new generation pre- pro- syn-biotics, or effective bioactive molecules (postbiotics) to be used in preventive nutritional strategies.

Group Berkem Wins Second Best Poster Presentation Award at Polyphenols Applications 2024

Congratulations to Jean-Paul Joseleau from Groupe Berkem for winning the Best Poster Presentation Award (2) at Polyphenols Applications 2024! His innovative research on “BERGENOL®, A Novel Vegetal Virucidal Agent for Hand Sanitizer Formulations” introduced a breakthrough in plant-based, alcohol-free sanitizers.

Derived from Vitis vinifera, Bergenol® demonstrated outstanding virucidal activity against a range of viruses, including those from the coronavirus and adenovirus families.

This recognition highlights the growing importance of natural, sustainable solutions in human hygiene, offering a safer alternative to chemical-based disinfectants. Well done to Dr. Joseleau for this achievement!

About Group Berkem

Groupe Berkem is a European Chemical manufacturer actively involved in the ecological transition. One of Groupe Berkem’s expertise is to use vegetal extracts in a wide range of sectors. It provides innovative and sustainable solutions to develop active ingredients for cosmetics and nutraceuticals, wood protection, disinfectants and human hygiene…

Nestlé Research Wins First Best Poster Presentation at Polyphenols Applications 2024

Dr. Laure Poquet of Nestlé Research has been awarded the Best Poster Presentation (1) at Polyphenols Applications 2024 for her outstanding research on oleuropein metabolites.

Her poster, “Oleuropein Metabolites Are Biologically Active as Mitochondrial Calcium Activators at the Concentration Measured in Human Plasma,” highlighted the bioactivity of these metabolites derived from olive leaf extracts.

The study demonstrated that, at concentrations measurable in human plasma, these metabolites can activate mitochondrial calcium, leading to enhanced energy metabolism in muscle cells.

A new study was performed by Nestlé scientists to understand how the polyphenols from olive leaf extract can boost muscle energy. The main natural polyphenolic compound of this extract is oleuropein. Its metabolites circulating in plasma after intake were detected and quantified using a validated LC-MS/MS method. Their potential biological activities as mitochondrial activators were tested in vitro, at the circulating concentrations. The results showed that, although the level of oleuropein was low, its metabolites are biologically active in skeletal muscle cells and reach a total concentration in human blood sufficient to activate mitochondrial energy metabolism via mitochondrial Ca2+ activation.

This achievement marks a significant step in understanding the role of oleuropein in improving muscle function and supporting healthy aging. Congratulations to Dr. Poquet on this well-deserved recognition!

Videos On-Demand now Available

All major and short oral presentations are now available on-demand. If you were not able to attend the live sessions, you can order and watch them later for 3 weeks. Order now.

Abstracts book of Polyphenols 2024 Congress

The Polyphenols Applications 2024 Abstracts Book - containing all 123+ major, short talks and poster presentations - is now available.

The book is assigned with a DOI (Digital Object Identifier). This ensures a permanent and easily accessible online presence for the entire collection of work.

Polyphenols Applications 2024 Posters List

More than 123 communications will be presented during Polyphenols Applications 2024, including more than 70 posters. Access full posters list. 

Last updated on 12/09/2024

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Call for Papers: Special Issue on Polyphenols in Molecular Nutrition & Food Research Journal

Molecular Nutrition & Food Research will be publishing a Special Issue following the 17th Polyphenols Applications 2024 World Congress, which took place in Milan, Sep 19th to 20th 2024.

Scientific sessions will focus on:

• Polyphenols in Health and Disease;
• Polyphenols, Microbiota and Metabolites;
• Polyphenols and Food Research;
• Clinical Applications and Future Directions. 

The special issue will be gratefully guest-edited by Juan Carlos Espin (CEBAS-CSIC, Murcia, Spain) & Cristian Del Bo' (University of Milan, Italy), most well-known for their high standard research in the field.

Juan Carlos Espin (CEBAS-CSIC, Murcia, Spain)

Cristian Del Bo' (University of Milan, Italy)

Call for Papers Open:

You can start submitting your papers now, following the technical details below:

• Contact email for authoring requests: This email address is being protected from spambots. You need JavaScript enabled to view it..
• Your request will be redirected to the guest editors who will decide on the selection of contributions.
• Submission deadline: December 31st 2024
• Article type: Research articles and Review articles will be accepted.
• Authors guidelines: here.

More information about the issue here.

Polyphenols in Oncotherapy: Moving forward from the Bench to Clinical Applications

It is a great pleasure to welcome Prof. José M. Estrela, University of Valencia, Spain, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Polyphenols in Oncotherapy: Moving forward from the Bench to Clinical Applications. 

Prof. Estrela will discuss the latest clinical data in oncotherapy using a combination of modalities including hyperthermia, electromagnetic fields, chemotherapy, and natural polyphenols.

Presentation Key Points

• Introduce the role of polyphenols, highlighting their potential as adjunctive therapies to enhance the efficacy of existing treatments.

• Discuss the rationale behind combining hyperthermia, electromagnetic fields, chemotherapy, and polyphenols, emphasizing the potential synergistic effects and mechanisms of action.

• Summarize preclinical evidence supporting the efficacy of the proposed combination therapy approach, including studies demonstrating tumor regression and enhanced cancer cell death.

• Outline the steps needed to translate preclinical findings into clinical applications, including regulatory considerations, clinical trial design, and patient safety assessments.

• Acknowledge potential challenges and limitations, such as variability in patient responses, treatment resistance, and the need for personalized treatment approaches.

• Explore future directions for research and innovation in polyphenol-based oncotherapy, including the development of novel delivery methods, targeted therapies, and precision medicine approaches.

About José M. Estrela

José M. Estrela is an Associate professor in the Department of Physiology, University of Valencia, Spain. His study interests major on Physiology. In recent years, he has studied several on Cancer, Oncology, Polyphenols, Cancer Therapy, Tumors. He has published more than 103 articles in many journals.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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The Potential of Polyphenols in the Context of Senotherapy

Dr. Alessandra Gambero, from Pontifical Catholic University of Campinas, Brazil, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

She will present her latest research on the Potential of Polyphenols in the Context of Senotherapy. 

Learn more about her findings.

Presentation Summary

• Cellular senescence is characterized by a stable cell proliferation arrest and the establishment of a secretory phenotype in normal cells in response to intrinsic and extrinsic stimuli.
• Cellular senescence is associated with chronological aging and a response to environmental stressors.
• Expanded knowledge about the role of senescence in the physiological context and disease processes and development of drugs that can counteract the harmful effects of cellular senescence as a therapeutic target.
• Therefore, senotherapeutics can be classified as senolytics drugs that selectively eliminate senescent cells or senostatics (senomorphic) that inhibit, reverse, or prevent aspects associated with cellular senescence.
• The most studied option combines dasatinib and quercetin, a natural polyphenol that targets BCL-2 and PI3K/AKT signaling pathways.
• The various pharmacological mechanisms described for polyphenols suggest that others may have senotherapeutic effects, which has been the focus of our recent work.

About Alessandra Gambero

Graduated in Biological Sciences from Paulista State University Júlio de Mesquita Filho (1994), Master in Biological Sciences (Pharmacology) from Paulista State University Júlio de Mesquita Filho (1997), PhD in Pharmacology from University of São Paulo (2001), and Post-doctoral at Paul Sabatier University (Toulouse, France). Currently develops projects in the research area of Aging and cellular senescence, Foods with health claims, and Regenerative Medicine and Innovation in Health.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Why Demonstrating the Health Benefits of Polyphenols isn't Easy: Considerations on Experimental Design to Enhance the Impact of Future Polyphenols Research

It is a great pleasure to welcome Prof. Daniele Del Rio, University of Parma, Italy, as a keynote speaker at the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

Prof. Del Rio will open the conference with a speech entitled "Why Demonstrating the Health Benefits of Polyphenols isn't Easy: Considerations on Experimental Design to Enhance the Impact of Future Polyphenols Research".

About Daniele Del Rio

Prof. Daniele Del Rio is a Full Professor of Human Nutrition at the Department of Food and Drug and the Head of the School of Advanced Studies on Food and Nutrition at the University of Parma, in Italy. He is also the scientific director of the NNEdPro Global Center for Nutrition and Health and a Visiting Professor at the School of Biomedical Sciences, Ulster University, UK.

He serves as Editor in Chief of the International Journal of Food Sciences and Nutrition (Taylor & Francis). He is a proud Commendatore (Knight Commander) of the Order of Merit of the Italian Republic, and he is proudly growing a team of brilliant scientists.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Coevolutionary Role of Host and Gut Microbiota in Polyphenol Health Effects: Metabotypes and Precision Health

It is a great pleasure to welcome Prof. Juan Carlos Espín, Spanish National Research Council, Spain, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Coevolutionary Role of Host and Gut Microbiota in Polyphenol Health Effects: Metabotypes and Precision Health. 

Presentation Summary

Individuals can be grouped into different metabotypes (metabolic types) based on their gut microbiota's ability to metabolize certain polyphenols, resulting in unique metabolites with varying molecular structures and biological activities. Thus, the effects of certain polyphenols will greatly depend on each individual's gut microbiota. By understanding the microbial ecologies responsible for these metabolic pathways, "precision-health" strategies could be developed to standardize the effects of polyphenols.

About Juan Carlos Espín

Juan Carlos Espín is is a full Research Professor at CEBAS-CSIC (Murcia, Spain). For the past 24 years, his main lines of research have focused on: i) the metabolism and biodistribution of polyphenols in humans, identifying the final responsible actors for biological effects; ii) the use of exosomes to deliver and enhance the biological activity of polyphenols and derived metabolites in systemic tissues; and iii) understanding why some polyphenols do not exert the same effect in all individuals. His research suggests that specific gut microbial ecologies play crucial roles in mediating the observed effects within the context of "precision health".

Juan Carlos has been a "highly-cited" researcher consecutively from 2018 to the present (only 0.1% of researchers worldwide are "highly-cited"). As of March 2024 (according to Scopus), he has an H-index of 85, with 230 JCR publications totaling approximately 23,000 citations, and has led the second highest-earning patent in the history of the CSIC.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Interplay between Polyphenolic Compounds and Biological Rhythms

Prof. Begoña Muguerza, from Universitat Rovira i Virgili, Spain, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

She will present her latest research on the Interplay between Polyphenolic Compounds and Biological Rhythms.

About Begoña Muguerza

She is a full Professor in the Biochemistry and Biotechnology Department, at the University Rovira I Virgili, Spain. Dr. Muguerza leads the Nutrigenomics Research Group, focusing its research on the study of the molecular mechanism by which food bioactive components, like (poly)phenols, exert health effects on metabolic pathologies. At present she is interested in the study of the interaction of the biological rhythms with the effectiveness of bioactive ingredients.

She has participated continuously in competitive projects, being PI of over 50. Dr. Muguerza is co-author of more than 150 articles in high-impact scientific journals and 15 patents. She has supervised 9 doctoral theses and currently she is mentoring 3 PhD students. In addition, she has also carried out management activities, being Head of the Biochemistry and Biotechnology Department and Coordinator of the Official Master Interuniversity Nutrition and Metabolism. Currently, she is the Coordinator of the Doctoral Programme in Nutrigenomics and Personalized Nutrition.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Food-Derived Extracellular Vesicles as Nanocarriers of Bioactive Compounds: Therapeutic Potential

Polyphenols Applications 2024 will welcome Dr. Alberto Davalos, University of Madrid, Spain, for its 17th World Congress this September in Milan.

Presentation Title: Food-Derived Extracellular Vesicles as Nanocarriers of Bioactive Compounds: Therapeutic Potential.

Presentation highlights

• Extracellular vesicles from mammalian and plants as novel players in intercellular communication
• Transport of natural bioactive molecules by dietary extracellular vesicles
• Methods to isolate extracellular vesicles from foods
• Delivery of bioactive compounds by extracellular vesicles
• Extracellular vesicles as nanocarriers of dietary polyphenols
• Therapeutic opportunities of dietary extracellular vesicles

About Alberto Davalos

Alberto Dávalos holds a degree in Pharmacy and Biochemistry by San Marcos University (Lima) and a PhD in Pharmacy by Universidad Complutense de Madrid (Madrid). He has conducted postdoctoral research at the Hospital Ramón y Cajal (Madrid), at Yale University School of Medicine, (New Haven), and at New York University School of Medicine (New York). Dr. Dávalos’s research program focuses in identifying and characterizing new noncoding RNAs (miRNAs, lncRNAs and other type of regulatory RNAs) that regulate lipid metabolism and the effects of minor dietary components (micronutrients) on their expression.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Contribution of Polyphenols in the Modulation of Intestinal Permeability: Targeting Mechanisms and Clinical Trials

Polyphenols Applications 2024 is honored to welcome Prof. Cristian Del Bo', active member of the scientific and local organizing committees, from Università degli Studi di Milano, Italy, as a speaker at its 17th World Congress this September in Milan.

Presentation Title: Contribution of Polyphenols in the Modulation of Intestinal Permeability: Targeting Mechanisms and Clinical Trials.

About Cristian Del Bo'

Cristian Del Bo’, PhD, is Associate Professor of Human Nutrition at the Department of Food, Environmental and Nutritional Sciences, at the University of Milan, Italy. His research focuses on the evaluation of the role of berries and berry-polyphenols in the modulation of markers related to cardiovascular risk. He performed both preclinical and clinical studies investigating the role blueberry bioactives in the modulation of vascular function, oxidative stress and inflammation. Prof Del Bo’ has published more than 100 articles in peer reviewed scientific journals. He is member of the Italian Society of Human Nutrition. He is on the Editorial Board of the International Journal of Food Sciences and Nutrition, and Nutrients. 

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Resveratrol/Omega-3 Fatty Acids Association: Innovative Nutraceuticals to Counteract Ocular Diseases

It is a great pleasure to welcome Prof. Dominique Delmas, University of Bourgogne, France, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Resveratrol/Omega-3 Fatty Acids Association: Innovative Nutraceuticals to Counteract Ocular Diseases. 

Prof. Delmas will highlight the molecular mechanistic, preclinical and clinical studies of this new combination.

About Dominique Delmas

He is currently full professor in Biochemistry, Cellular and Molecular Biology at the University of Bourgogne (France). He exercises the function of Deputy Director of the Inserm Research Center Unit U1231 “Lipids, Nutrition, Cancers” in Dijon where he manages a research group entitled “Bioactive Molecules and Health” within the Inserm team “Cancer and Adaptive Immune Response”. He received his PhD on December 16th, 2002 concerning the potential antitumor effects of polyphenols, among them resveratrol. 

The main research objectives of his group are to develop and to coordinate multidisciplinary and translational research from laboratory to clinical applications, including 1) the determination of early biomarkers in response to treatment; 2) the identification of new potential targets and the development of new therapeutic strategies by the use of molecules with low toxicity with a special attention on polyphenols. Due to the experience acquired in the field of natural substances and their implications in biology, he is an expert for many national and international organizations and member of the editorial board of several scientific journals (PLOS One, ACAMC, Nutrients, ROS journals). He has authored or coauthored over 97 original papers and comprehensive reviews on polyphenols health effects. He has also contributed to over 20 books chapters concerning the molecular mechanisms of polyphenols in tumoral cells and 118 international communications.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Novel Development on the Potential Application of Pyranoanthocyanin as Colorants

Prof. Monica Giusti, Ohio State University, USA, will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

She will present the Novel Development on the Potential Application of Pyranoanthocyanin as Colorants.

Presentation Summary

• Pyranoanthocyanins are derived from anthocyanins and are key contributors to the extra long stability of red wine color. 
• Yet, their limited stability limits their application in foods.
• Different strategies were developed by Prof. Gusti and her team to produce a wide variety of pyranoanthocyanins from an array of different anthocyanin precursors, and in combination with different cofactors.
• These pyranoanthocyanins show superior stability to factors such as pH, bleaching agents and heat.
• They also present new challenges such as their decreased solubility in water and the low efficiency of production.
• Different strategies to increase the yields of pyranoanthocyanin production from different sources will be discussed, as well as the role of their chemical structure on pyranoanthocyanin color, solubility, stability and potential for food applications. 

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Angiogenesis as a Target of Dietary (Poly)phenols and Derived Metabolites

It is a great pleasure to welcome Dr. Juan A. Giménez-Bastida, CEBAS-CSIC, Spain, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Angiogenesis as a Target of Dietary (Poly)phenols and Derived Metabolites.

Presentation Summary

• Emphasis on the utilization of natural compounds, particularly (poly)phenols, as a promising avenue for regulating angiogenesis.
• Objective: Provide comprehensive insights into the specific molecules capable of modulating angiogenic processes and elucidate the mechanisms through which these effects are realized.
• Findings from preclinical investigations demonstrated the efficacy of tested (poly)phenols, whether identified in the bloodstream or systemic tissues, in modulating key in vitro angiogenesis processes.
• Potential for transitioning from in vitro models to in vivo studies to further validate the efficacy and safety of (poly)phenols in regulating angiogenesis.

About Juan A. Giménez-Bastida

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Antiviral Activity of Polyphenols: Latest Developments

Prof. Sascha Venturelli, from the University of Hohenheim, Germany,  will be joining the 17th World Congress on Polyphenols Applications 2024 this September in Milan.

He will present the latest developments in the antiviral activity of polyphenols. 

Presentation Summary

• The heterogenous class of polyphenols exhibit surprising and interesting antiviral effects.
• The COVID-19 pandemic has also inspired research on polyphenols and their health promoting properties.
• Current research including our own findings show that prenylated flavonoids (e.g. 6-prenylnaringenin) inhibit important viral enzymes of SARS-CoV-2.
• Also other polyphenols (like quercetin and curcumin) exert antiviral effects on SARS-CoV-2.
• Polyphenols seem to be promising natural drug candidates for other human viral diseases (e.g. hepatitis, influenca).

About Sascha Venturelli

Prof. Dr. Dr. Venturelli completed his biology studies at the Albert-Ludwigs-University of Freiburg and received his diploma with distinction in 2002. He successfully completed his medical studies with study visits at University College London Hospitals (Great Britain), Porter Memorial Hospital (USA) and University Hospital Zurich (Switzerland) at the Eberhard Karls University Tübingen in 2008. Both his scientific doctorate at the University of Hohenheim and his medical dissertation at the University Hospital of Tübingen were awarded "summa cum laude".

Initially, Prof. Dr. Dr. Venturelli worked as head of laboratory at the Department of Internal Medicine I at the University Hospital in Tübingen. During this time, he spent a research stay at the Peter MacCallum Cancer Centre in Melbourne (Australia) in the renowned research group of Prof. Ricky Johnstone from 2011 to 2012, funded by the DFG. Upon his return to the University Hospital in Tübingen, he established his own research group focusing on epigenetics and nutrition in the context of oncology as part of the Excellence Initiative of the Eberhard Karls University of Tübingen. In addition to his function as a study physician, during this time new active substances for cancer therapy were identified, characterised and successfully patented by the University Hospital of Tübingen. Prof. Dr. Dr. Venturelli was appointed deputy director of the Department of Vegetative and Clinical Physiology, Eberhard Karls University of Tübingen in 2016 and academic director in 2017.

In addition to various activities in the context of university self-administration such as study and examination commissioner, he was appointed to various national and international committees. In 2019 Prof. Dr. Dr. Venturelli accepted the call for the W3-Professorship at the University of Hohenheim and has since then been head of the Department of Biochemistry of Nutrition at the Institute of Nutritional Sciences.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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Effects of Polyphenols on Diabetes: A Mechanistic Insight

It is a great pleasure to welcome Dr. Sonia Ramos Rivero, ICTAN-CSIC, Spain, to Polyphenols Applications 2024 this September in Milan.

Presentation Topic: Effects of Polyphenols on Diabetes: A Mechanistic Insight. 

Dr. Ramos will discuss the role of dietary polyphenols in diabetes type 2 highlighting their molecular mechanism of action, also in combination with anti-diabetic drugs.

About Sonia Ramos Rivero

Sonia Ramos is a Tenured Scientist at ICTAN-CSIC (Madrid, Spain), and she participates as a Researcher at the “Centro de Investigación Biomédicas en Red de Diabetes y Enfermedades Metabólicas Asociadas” (CIBERDEM). Her research activity in the field of nutritional biochemistry is focused on the study of the molecular mechanisms of action of bioactive food components, mainly phenolic compounds and their metabolites, and their potential effect on health and on the prevention of chronic diseases related to the oxidative stress, such as diabetes.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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